教育经历 Education 1985年9月－1989年7月 北京大学技术物理系 学士学位Department of Technical Physics, Peking University, B.Sc. 1989年9月－1992年7月 中科院上海有机所 硕士学位SIOC, MS 1992年9月－1995年7月 中科院上海有机所 博士学位SIOC, Ph.D 工作经历 Professional Experience 1995年9月－1996年8月 美国纽约大学化学系 博士后Postdoc, New York University 1996年9月－1997年8月 中科院上海有机所 助理研究员Assistant Professor, SIOC 1997年9月－1999年11月 中科院上海有机所 副研究员Associate Professor, SIOC 1999年12月－至今 中科院上海有机所 研究员Professor, SIOC 主要学术兼职 Major Joint Positions 2002年－2005年 中国海洋大学 兼职教授Ocean University of China, Joint Professor 2004年－至今 中国科学技术大学 兼职博导University of Science and Technology of China, Joint Professor 2009年－至今 华东理工大学 特聘讲座教授East China University of Science and Technology, Honorary Professor 2010年－至今 上海高校E-化学生物学研究院 特聘研究员E-Institutes of Shanghai Municipal Education Commission, Joint Professor 2013年－至今 上海科技大学 教授ShanghaiTech University, Joint Professor 2004-current National Representative, International Carbohydrate Organization 2009-current Steering Committee Member, Asian Communications of Glycobiology and Glycotechnology 2011 Vice president, International Heterocyclic Chemistry Society 2005-current Carbohydrate Research, Editorial Board Member 2010-current Journal of Asian Natural Products Research, Editorial Board Member 2010-current Natural Products and Bioprospecting, Editorial Board Member 2011-current Asian Journal of Organic Chemistry, Editorial Board Member 2012-current Chinese Chemical Letters, Editorial Board Member 2012-current Acta Chimica Sinica, Editorial Board Member 2013-current Organic Chemistry Frontiers, Editorial Board Member 2014-current Advances in Carbohydrate Chemistry and Biochemistry, Board of Advisors 2017-current Chinese Journal of Chemistry, Associate Editor 所获荣誉 Awards 1997年 中国科学院“发明二等奖” （免疫调节剂－牛膝多糖） 1998年 中国化学会“青年化学奖” 1998-1999年度 上海市科技系统“优秀青年科技工作者” 1999年 明治乳业生命科学奖 1999年; 2002年 上海市“科技启明星基金” 2000年 国家杰出青年基金 2000年 施维雅青年药物化学奖 2000年 中国科学院杰出青年(十人) 2004年 上海市优秀留学回国人才 2004年 政府特殊津贴 中华人民共和国国务院 2006年 上海市自然科学二等奖（具有重要生理活性的复杂糖缀合物的化学合成） 2007年 药明康德生命化学研究奖 2010年 国家自然科学奖二等奖（具有重要生理活性的复杂糖缀合物的化学合成） 2010年 庄长恭奖 上海市化学化工学会 2012年 礼来杰出科研奖 （Eli Lilly Scientific Excellence Award） 2012年 第九届上海市自然科学牡丹奖 上海市科学技术委员会 2013年 青年科技杰出贡献奖 上海市人民政府 2014年 中科院朱李月华优秀教师奖 2016年 Fellow of the Royal Society of Chemistry (FRSC) 2019-current 《高等学校化学学报》 编委 （Chemical Research in Chinese Universities, Associate Editor-in-Chief）

具有重要生理活性的复杂寡糖、糖缀合物及其它天然产物，如：动物糖胺聚糖(如肝素)和特征肿瘤抗原、微生物抗生素、植物和海洋糖苷(如皂甙和黄酮甙)等的全合成、合成方法学和化学生物学. 其它研究内容还涉及：中药；天然产物的分离鉴定；糖基转移酶和糖苷水解酶抑制剂；兼亲分子的超分子化学等.

Research Progress in Methods for Glycan Sulfation. Qingqing Shi, Peng Xu, Biao Yu, Sci. Sin. Chim. 2025. DOI: 10.1360/SSC-2025-0073 Advanced RPL19-TRAPKI-seq method reveals mechanism of action of bioactive compounds. Di Zhu, Junchi Hu, Renke Tan, Xiaofeng Lin, Ruina Wang, Junyan Lu, Biao Yu, Yongmei Xie, Xiaohua Ni, Chunmin Liang, Yongjun Dang, Wei Jiang, Nat. Prod. Bioprospect. 2025, 15, 16. DOI: 10.1007/s13659-025-00500-3 Modular Synthesis of the Potent Antibiotic Amycolamicin and Diastereomeric Analogues Thereof. Xuejian Yin, Zhengxuan Zhang, Ziqi Yuan, Qiuyu Zhu, Peng Xu, Cai-Guang Yang, Dapeng Zhu, Biao Yu, Org. Lett. 2025, 27, 3631-3636. DOI: 10.1021/acs.orglett.5c00742 A Dehydrative Glycosylation Protocol Mediated by Cp2ZrCl2-AgN(SO2F)2∙2MeCN. Yu Tang, Jia Yu, Chun Hu, Biao Yu, Asian J. Org. Chem. 2025. DOI: 10.1002/ajoc.202500418 Gold(I)-Catalyzed 2-Deoxy-β-glycosylation via 1,2-Alkyl/Arylthio Migration: Synthesis of Velutinoside A Pentasaccharide. Xianyang Wang, Han Ding, Aoxin Guo, Xiaofei Song, Peng Wang, Ni Song, Biao Yu, Peng Xu, Xue-Wei Liu, Ming Li, J. Am. Chem. Soc. 2025, 147, 4469-4481. DOI: 10.1021/jacs.4c15805 1,2-trans and regioselective glycosylation of multihydroxy sugars via a simple yet synergistic combination of BF3·Et2O in THF. Zhimei Wang, Longwei Gao, Yingjie Wang, Fuzhu Yang, Jinpeng Sang, Shuheng Pan, Xin Huang, Pan Zhang, Weijia Xie, Xiaoxing Wu, Biao Yu, Peng Xu, Xiaheng Zhang, Zhaolun Zhang, Wei Li, Green Chem. 2025, 27, 2331-2341. DOI: 10.1039/D4GC04572F Chemical Synthesis of β-(1,4)-d-Oligomannurarates with Purported Anti-Alzheimer Activity. Xiaofei Shao, Peng Xu, Biao Yu, Eur. J. Org. Chem. 2025, 28, e202401125. DOI: 10.1002/ejoc.202401125 Time-course remodeling and pathology intervention of α-synuclein amyloid fibril by heparin and heparin-like oligosaccharides. Youqi Tao, Peng Xu, Shenqing Zhang, Wei Shangguan, Guang Yang, Kaien Liu, Xiang Li, Yunpeng Sun, Qinyue Zhao, Dan Li, Biao Yu, Cong Liu, Nat. Struct. Mol. Biol. 2025, 32, 369-380. DOI: 10.1038/s41594-024-01407-2 Stereoselective chemical N-glycoconjugation of amines via CO2 incorporation. Zihan Peng, Qian Xiao, Yan Xia, Mingyu Xia, Jia Yu, Pengfei Fang, Yu Tang, Biao Yu, Nat. Commun. 2024, 15, 10373. DOI: 10.1038/s41467-024-54523-4 Expeditious chemical synthesis of xylomannans disproves the proposed antifreeze activities. Qian Zhu, Simone Nicolardi, Yuanguang Wang, Yasong Liu, Peng Xu, Jianjun Wang, Dapeng Zhu, Biao Yu, Natl. Sci. Rev. 2024, 11, nwae296. DOI: 10.1093/nsr/nwae296 Bio-inspired synthesis and bioactivities of phenylethanoid glycoside crenatosides. Qingqing Shi, Haotian Li, Tao Yang, Luyao Qi, Wei Tang, Peng Xu, Biao Yu, Org. Chem. Front. 2024, 11, 5396-5400. DOI: 10.1039/D4QO01062K Synthesis of Acovenosides: Cardiac Glycosides with Potent Antitumor Activities. Benzhang Liu, Shuyang Bi, Jing Wang, Peng Xu, Biao Yu, Org. Lett. 2024, 26, 8725-8729. DOI: 10.1021/acs.orglett.4c03048 A Ligand-Controlled Approach Enabling Gold(I)-Catalyzed Stereoinvertive Glycosylation with Primal Glycosyl ortho-Alkynylbenzoate Donors. Weiping Zhou, Renjie Wu, Jinchan Li, Dapeng Zhu, Biao Yu, J. Am. Chem. Soc. 2024, 146, 27915-27924. DOI: 10.1021/jacs.4c10698 Decoding the molecular mechanism of selective autophagy of glycogen mediated by autophagy receptor STBD1. Yuchao Zhang, Yishan Sun, Jungang Shi, Peng Xu, Yingli Wang, Jianping Liu, Xinyu Gong, Yaru Wang, Yubin Tang, Haobo Liu, Xindi Zhou, Zhiqiao Lin, Otto Baba, Tsuyoshi Morita, Biao Yu, Lifeng Pan, Proc. Natl. Acad. Sci. U.S.A. 2024, 121, e2402817121. DOI: 10.1073/pnas.2402817121 Regiodivergent Functionalization of Protected and Unprotected Carbohydrates using Photoactive 4-Tetrafluoropyridinylthio Fragment as an Adaptive Activating Group. Shen Cao, Haobo Zhang, Mingshuo Chen, Niming Zhu, Beibei Zhan, Peng Xu, Xiaoping Chen, Biao Yu, Xiaheng Zhang, Angew. Chem. Int. Ed. 2024, 63, e202412436. DOI: 10.1002/anie.202412436 Insight into gold-catalyzed glycosylation of glycosyl ynenoates. Lvfeng Zhang, Youling Liang, Xiaona Li, Rongkun Liu, Jibin Zheng, Peng Xu, Biao Yu, You Yang, J. Carbohydr. Chem. 2024, 43, 21-36. DOI: 10.1080/07328303.2024.2366774 Chemical synthesis and functional evaluation of glycopeptides and glycoproteins containing rare glycosyl amino acid linkages. Weizhun Yang, Sherif Ramadan, Yan Zu, Mengxia Sun, Xuefei Huang, Biao Yu, Nat. Prod. Rep. 2024, 41, 1403-1440. DOI: 10.1039/D4NP00017J Carbohydrate Chemistry in the Total Synthesis of Naturally Occurring Glycosides. Biao Yu, Xiaoyu Yang, Wiley-VCH 2024, ISBN: 978-3-527-34519-9. Microwave-assisted synthesis of highly sulfated mannuronate glycans as potential inhibitors against SARS-CoV-2. Yirong Zhu, Xiaotong Wang, Siqian Lu, Jibin Zheng, Youling Liang, Liangliang Zhang, Pengfei Fang, Peng Xu, Biao Yu, You Yang, Org. Biomol. Chem. 2024, 22, 3986-3994. DOI: 10.1039/D4OB00466C Merging total synthesis and NMR technology for deciphering the realistic structure of natural 2,6-dideoxyglycosides. Zhaolun Zhang, Renjie Wu, Shen Cao, Jiaji Li, Guangen Huang, Haoyu Wang, Tao Yang, Wei Tang, Peng Xu, Biao Yu, Sci. Adv. 2024, 10, eadn1305. DOI: 10.1126/sciadv.adn1305 Expeditious Synthesis of Gwanakoside A and the Chloronaphthol Glycoside Congeners. Yuting Cheng, Yan Xia, Ziqi Yuan, Haotian Li, Jing Wang, Yingjie Wang, Cai-Guang Yang, Biao Yu, Org. Lett. 2024, 26, 2425–2429. DOI: 10.1021/acs.orglett.4c00573 Direct Synthesis of α- and β-2′-Deoxynucleosides with Stereodirecting Phosphine Oxide via Remote Participation. Xintong Tang, Yueer Zhou, Yingjie Wang, Yetong Lin, Shuheng Pan, Qianwei Che, Jinpeng Sang, Ziming Gao, Weiting Zhang, Yuanyuan Wang, Guolong Li, Longwei Gao, Zhimei Wang, Xudong Yang, Ao Liu, Suyu Wang, Biao Yu, Peng Xu, Zhe Wang, Zhaolun Zhang, Peng Yang, Weijia Xie, Haopeng Sun, Wei Li, J. Am. Chem. Soc. 2024, 146, 8768–8779. DOI: 10.1021/jacs.4c01780 Atomic-Level Dissection of DC-SIGN Recognition of Bacteroides vulgatus LPS Epitopes. Ferran Nieto-Fabregat, Qian Zhu, Corinne Vivès, Yunqin Zhang, Angela Marseglia, Fabrizio Chiodo, Michel Thépaut, Diksha Rai, Suvarn S. Kulkarni, Flaviana Di Lorenzo, Antonio Molinaro, Roberta Marchetti, Franck Fieschi, Guozhi Xiao, Biao Yu, Alba Silipo, JACS Au 2024, 4, 697-712. DOI: 10.1021/jacsau.3c00748 Dimethyl sulfate and diisopropyl sulfate as practical and versatile O-sulfation reagents. Shuaishuai Yue, Guoping Ding, Ye Zheng, Chunlan Song, Peng Xu, Biao Yu, Jiakun Li, Nat. Commun. 2024, 15, 1861. 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Haoliang Zhang, Changgen Zeng, Qian Zhu, Dapeng Zhu, Biao Yu, Chem. Eur. J. 2024, 30, e202304180. DOI: 10.1002/chem.202304180 AcGlcAs: A Novel P53-Targeting Arsenical with Potent Cellular Uptake and Cancer Cell Selectivity. Ying Liang, Quanlin An, Huaxin Song, Yigang Tang, Shujun Xiao, Jiale Wu, Ni Yan, Biao Yu, Xin Cao, Min Lu, J. Med. Chem. 2023, 66, 16579–16596. DOI: 10.1021/acs.jmedchem.3c00104 Synthesis of Anticoagulant Pentasaccharide Fondaparinux via 3,5-Dimethyl-4-(2′-phenylethynylphenyl)phenyl Glycosides. Wei Liu, Zhifei Hu, Peng Xu, Biao Yu, Org. Lett. 2023, 25, 8506–8510. DOI: 10.1021/acs.orglett.3c03484 Natural product P57 induces hypothermia through targeting pyridoxal kinase. Ruina Wang, Lei Xiao, Jianbo Pan, Guangsen Bao, Yunmei Zhu, Di Zhu, Jun Wang, Chengfeng Pei, Qinfeng Ma, Xian Fu, Ziruoyu Wang, Mengdi Zhu, Guoxiang Wang, Ling Gong, Qiuping Tong, Min Jiang, Junchi Hu, Miao He, Yun Wang, Tiejun Li, Chunmin Liang, Wei Li, Chunmei Xia, Zengxia Li, Dengke K. Ma, Minjia Tan, Jun Yan Liu, Wei Jiang, Cheng Luo, Biao Yu, Yongjun Dang, Nat. Commun. 2023, 14, 5984. DOI: 10.1038/s41467-023-41435-y Tetramerization of upstream stimulating factor USF2 requires the elongated bent leucine zipper of the bHLH-LZ domain. Cao Huang, Mingyu Xia, Hang Qiao, Zaizhou Liu, Yuqi Lin, Hanyin Sun, Biao Yu, Pengfei Fang, Jing Wang, J. Bio. Chem. 2023, 299, 105240. DOI: 10.1016/j.jbc.2023.105240 Synthesis of 2-Indolyl C-Glycoside Neopetrosins A and C and Congeners via Ni-Catalyzed Photoreductive Cross-Coupling. Yan Xia, Yingjie Wang, Zhaolun Zhang, Tayyab Gulzar, Yuqi Lin, Jing Wang, Dapeng Zhu, Biao Yu, Org. Lett. 2023, 25, 6741–6745. DOI: 10.1021/acs.orglett.3c02601 Molecular recognition of trehalose and trehalose analogues by Mycobacterium tuberculosis LpqY-SugABC.. Jingxi Liang, Fengjiang Liu, Peng Xu, Wei Shangguan, Tianyu Hu, Shule Wang, Xiaolin Yang, Zhiqi Xiong, Xiuna Yang, Luke W. Guddat, Biao Yu, Zihe Rao, Bing Zhang, Proc. Natl. Acad. Sci. U. S. 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DOI: 10.1515/pac-2022-1114 Inhibiting autophagy before it starts. Yuqi Lin, Biao Yu, Pengfei Fang, Jing Wang, Autophagy 2023. DOI: 10.1080/15548627.2023.2197364 Synthesis of Unprecedented α/β-Alternate (1→4)-Glucans via Stereoselective Iterative Glycosylation. Fuzhu Yang, Yishan Sun, Peng Xu, Antonio Molinaro, Alba Silipo, Biao Yu, Chem. Eur. J. 2023, 29, e202300659. DOI: 10.1002/chem.202300659 An Anomeric Base-Tolerant Ester of 8-Alkynyl-1-Naphthoate for the Gold(I)-Catalyzed Glycosylation Reaction. Xiaojuan Zhang, Peng Xu, Zhengbing Zhou, Yazhou Zhang, Biao Yu, Yugen Zhu, Chin. J. Chem. 2023, 41, 1305-1312. DOI: 10.1002/cjoc.202300005 A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB. Yuqi Lin, Qiqi Shi, Guang Yang, Fuchun Shi, Yang Zhou, Tongtong Wang, Peng Xu, Peifeng Li, Zaizhou Liu, Hanyin Sun, Zhixin Zhao, Ke Ding, Zhen Wang, Haizhong Feng, Biao Yu, Pengfei Fang, Jing Wang, Proc. Natl. Acad. Sci. U.S.A. 2023, 120, e2213670120. 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DOI: 10.1021/acs.orglett.2c01146 Total Synthesis of Starfish Cyclic Steroid Glycosides. Dapeng Zhu, Mingyu Geng, Biao Yu, Angew. Chem. Int. Ed. 2022, 61, e202203239. DOI: 10.1002/anie.202203239 More than a Leaving Group: N-Phenyltrifluoroacetimidate as a Remote Directing Group for Highly α-Selective 1,2-cis Glycosylation. Xianglai Liu, Yingying Song, Ao Liu, Yueer Zhou, Qian Zhu, Yetong Lin, Huiyong Sun, Kaidi Zhu, Wei Liu, Ning Ding, Weijia Xie, Haopeng Sun, Biao Yu, Peng Xu, Wei Li, Angew. Chem. Int. Ed. 2022, 61, e202201510. DOI: 10.1002/anie.202201510 A mild heteroatom (O-, N-, and S-) methylation protocol using trimethyl phosphate (TMP)-Ca(OH)2 combination. Yu Tang , Biao Yu, Synthesis 2022, 54, 2373-2390. DOI: 10.1055/a-1731-3852 Total Synthesis and Stereochemistry Assignment of Nucleoside Antibiotic A-94964. Xiaofei Shao, Chang Zheng, Peng Xu, Taro Shiraishi, Tomohisa Kuzuyama, Antonio Molinaro, Alba Silipo, Biao Yu, Angew. Chem. Int. Ed. 2022, 61, e202200818. 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