袁钧瑛 照片

袁钧瑛

研究员 博导

所属大学: 中国科学院上海有机化学研究所

所属学院: 生命有机化学国家重点实验室

邮箱:
junying_yuan@sioc.ac.cn

个人主页:
http://www.sioc.cas.cn/sourcedb/cn/team/yjy/201312/t20131210_6773133.html

个人简介

1977-1982   复旦大学生物化学学士 1982-1989   哈佛大学神经生物学博士研究生 1990-1991   哈佛大学医学院讲师 1992-1996   哈佛大学医学院医学助理教授 1996-2000   哈佛大学医学院细胞生物学副教授 2000-2020/9  哈佛大学细胞生物学教授 2014-2020/9  哈佛大学医学院生物细胞学Elizabeth D. Hay冠名荣誉教授 2020/10-至今 中国科学院上海有机化学研究所生物与化学交叉研究中心主任, 研究员

研究领域

主要研究目标是揭示哺乳动物细胞中调控细胞死亡的分子机制。袁钧瑛教授为开创两个主要的细胞死亡研究领域,包括细胞凋亡(apoptosis)和细胞坏死(necroptosis),做出了里程碑式的贡献。她的工作阐明了一系列在这两种细胞死亡方式中的关键驱动分子, 分子机制以及与人类疾病的关系

近期论文

Yuan JY, Horvitz HR. The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. Dev Biol. 1990 Mar;138(1):33-41. PMID: 2307287. Yuan J, Horvitz HR. The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death. Development.1992 Oct;116(2):309-20. PMID: 1286611. Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell. 1993. Nov 19;75(4):641-52. PMID: 8242740. Yuan J, Horvitz HR. A first insight into the molecular mechanisms of apoptosis. Cell.2004; 116(2 Suppl):S53-6, 1 p following S59. PMID: 15055582 Miura M, Zhu H, Rotello R, Hartwieg EA, Yuan J. Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell. 1993 Nov 19;75(4):653-60. PMID: 8242741. Gagliardini V, Fernandez PA, Lee RK, Drexler HC, Rotello RJ, Fishman MC, Yuan J. Prevention of vertebrate neuronal death by the crmA gene. Science. 1994 Feb 11;263(5148):826-8. PubMed PMID: 8303301. Wang L, Miura M, Bergeron L, Zhu H, Yuan J. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell. 1994 Sep 9;78(5):739-50. PMID: 8087842. Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 1998 Aug 21;94(4):491-501. PMID: 9727492. Sánchez I, Xu CJ, Juo P, Kakizaka A, Blenis J, Yuan J. Caspase-8 is required for cell death induced by expanded polyglutamine repeats. Neuron. 1999 Mar;22(3):623-33. PMID: 10197541. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature. 2000 Jan 6;403(6765):98-103. PMID: 10638761. Wang S, Miura M, Jung YK, Zhu H, Li E, Yuan J. Murine caspase-11, an ICE interacting protease, is essential for the activation of ICE. Cell. 1998 Feb 20;92(4):501-9. PMID: 9491891. Kang SJ, Wang S, Hara H, Peterson EP, Namura S, Amin-Hanjani S, Huang Z, Srinivasan A, Tomaselli KJ, Thornberry NA, Moskowitz MA, Yuan J. Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions. J Cell Biol. 2000 May 1;149(3):613-22. PMID: 10791975; PMCID: Li J, Brieher WM, Scimone ML, Kang SJ, Zhu H, Yin H, von Andrian UH, Mitchison T, Yuan J. Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. Nat Cell Biol. 2007 Mar;9(3):276-86. PMID: 17293856. Py BF, Jin M, Desai BN, Penumaka A, Zhu H, Kober M, Dietrich A, Lipinski MM, Henry T, Clapham DE, Yuan J. Caspase-11 controls interleukin-1β release through degradation of TRPC1. Cell Rep. 2014 Mar 27;6(6):1122-8. PMID: 24630989. Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol. 2008 May;4(5):313-21. PMID: 18408713. Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, Yuan J. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell. 2008 Dec 26;135(7): 1311-23. PMID: 19109899. Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J. RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science. 2016 Aug 5;353(6299):603-8. PMID: 27493188. Ofengeim D, Mazzitelli S, Ito Y, DeWitt JP, Mifflin L, Zou C, Das S, Adiconis X, Chen H, Zhu H, Kelliher MA, Levin JZ, Yuan J. RIPK1 mediates a disease-associated microglial response in Alzheimer's disease. Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8788-E8797. PMID: 28904096. Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, Aron L, Adiconis X, Levin JZ, Yankner BA, Yuan J. TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Cell. 2018 Sep 6;174(6):1477-1491. PMID: 30146158. Xu D, Zhao H, Jin M, Zhu H, Shan B, Geng J, Dziedzic SA, Amin P, Mifflin L, Naito MG, Najafov A, Xing J, Yan L, Liu J, Qin Y, Hu X, Wang H, Zhang M, Manuel VJ, Tan L, He Z, Sun ZJ, Lee VMY, Wagner G, Yuan J. ModulatingTRADDto restore cellular homeostasis and inhibit apoptosis. Nature. 2020 Sep 23. doi: 10.1038/s41586-020-2757-z. PMID: 32968279