工作经历 1960年9月至今：中国科学院上海有机化学研究所，研究员 1956年8月至1960年8月：中国科学院上海有机化学研究所，副研究员 1955年9月至1956年7月：化工部医药工业管理局，副总工程师 1948年5月至1951年6月：上海人民制药一厂，研究部技术员 教育背景 1944年9月至1948年5月：前国立药学专科学校，毕业。 1951年9月至1955年9月：莫斯科全苏药物化学研究所研究生，科学副博士。 主要获奖情况 国家自然科学奖（二等）， 一项，（1982年）。 国家发明奖（三等）， 三项，（1987、1988、1990年）。 国家科技进步奖（二等）， 一项，（1985年）；（三等），一项，（1987年）。 国防科工委奖状、奖章， （1988年。） 何梁何利奖，（2001年）

具生物活性有机小分子的设计、合成及构效关系研究。 氨基膦酸及磷肽的不对称合成。 酶催化反应

1. D. Zhang, C. Yuan*; “An Enantioselective Nucleophilic Addition of α,β-Unsaturated Trifluoromethylketones Catalyzed by L-proline Derivatives” , Tetrahedron 2008, 64, 2480-2488. 2. Q. Chen, C. Yuan*; “A Facile Synthesis of Chiral 4-(tert-Butylsulfinyalmino)-2-Oxo-Phosphonates and Their Conversion into 5,5-Disubstituted 2-Benzulidene-3-oxo-Pyrolidines”; Synthesis 2008, 1085-1093. 3. A. Degterev, J. Hitomi, M. Germscheid, I. L. Ch’en, O. Korkina, X. Teng, D. Abbott, G. D. Cuny, C. Yuan, G. Wagner, S. M. Hedrick, S. A. Gerber, A. Lugovskoy & J. Yuan*. “Identification of R1P1 Kinase as a Specific Cellular Target of Necrostatins”; Nature Chemical Biology 2008, 4, 313-321. 4. D. Zhang, C. Yuan*; “A Concise and First Synthesis of α-Aminophosphinates with Two Stereogenic Atoms Leading to Optically Pure α-Amino-H-Phosphinic Acids”; Chemistry, A European Journal 2008, 14, 6049-6052. 5. Q. Chen, C. Yuan*; “Sulfinimine_medated Asymmetric Synthesis of Acyclic and Cyclic α-Amino- phosphonates”; Synthesis 2008, 2986-2990. 6. W. Zheng, A. Degterev, E. Hsu, J. Yuan, C. Yuan*; “Structure-activity Relationship Study of A Novel Necroptosis Inhibitor, Necrostatin-7”; Bioorg. & Med. Chem. Lett. 2008, 18, 4932-4935. 7. Q. Chen, C. Yuan*; “An Unexpected Ruthenium Complex and Its Unique Behavior as Catalyst in Dynamic Kinetic Resolution of Secondary Alcohols”; Chem Comm 2008, 5333-5335 8. J. Yuan, C. Yuan and D. Alexei; “Compounds, Screens and Methods of Treatment”; PCT Int. Appl 2008, Patent No. Application No. WD 2008045406, 20080417. 9. D. Zhang, C. Yuan*; “First and Highly Enantioselective Synthesis of β-Amiophosphinate with two Stereogenic Atoms and Their Conversion to Optically Pure Ethyl β-Amino-H-phosphinates”; Chemistry, A European Journal 2009 (in press) 10. Q. Chen, K. Wang and C. Yuan*; “A Chemoenzymatic Synthesis of Chiral Secondary Alcohols Bearing Sulfur-containing Functionality”; New Journal of Chemistry 2009, DOI:10.1039/b820192g 11. K. Wang, J. Li, J. Yuan, C. Yuan*; “Method of Synthesis of 3-Aryl-5,6-Substituted Thiophenopyrimin-4-Carbonyl-2-Mercaptionacetionitriles”; Chinese Patent (Issued 2008-11-5) ZL 2006 1 0117097X 12. Q. Chen, C. Yuan*; “A New and Convenient Asymmetric Synthesis of α-Amino- and α-Alkyl- α-amino-phosphonic Acids Using N-tert-Butylsulfinyl Imines as Chiral Auxiliaries”; Synthesis 2008, 3779-3786. 13. D. Zhang, C. Yuan*; “Reaction of 1,2-unsaturated trifluoromethyl ketones and their Conversion to 1-trifluoromethylfurane derivatives”; Eur. J. Org. Chem. 2007, 23, 3916-3924. 14. K. Wang, J. Li, J.Yuan, C. Yuan*; “Structure-Activity Relationship Analysis of a Novel Necroptosis Inhibitor, Necrostain-5”; Bioorg. & Med. Chem. Lett. 2007, 17, 1455-1465. 15. C. Yuan*, J. Li, W. Zhang; “A Facile Chemoenzymatic Method for the Preparation of Chiral 1,2-Dihydroxy-3,3,3-Trifluoropropanephosphonates”; J.Fluorine. Chem. 2006, 127, 44-47. 16. W. Zheng, C. Yuan*; “Synthesis of 3-Trifluoro-2-Hydroxy/amino-1-Fluoropropanephosphonates”; Chin. J. Chem. 2006, 24, 1170-1174. 17. D. Gong, J. Li, C. Yuan*, J. Yuan; “Synthetic study of substituted arylsulfonylphenylbenzamides” Synth. Commun. 2005, 34, 55-66. 18. C. Xu, C. Yuan*; “Candida Rugosa lipase-catalyzed kinetic resolution of β-hydroxy-β-aryl-Propionates and δ-hydroxy-δ-aryl- β-oxo-pentanoates”; Tetrahedron 2005, 61, 2169-2186. 19. C. Yuan*, Q. Chen; “Facile and efficient asymmetric synthesis of αlpha-aminoalkylphosphonic acids” Chin. J. Chem. 2005, 23, 1671-1676. 20. C. Xu, Y. Zhang, C. Yuan*; “A chemoenzymatic approach to optically active 5-hydroxy-3-oxo- carboxylates” Synlett. 2004, 3, 485-488. 21. C. Xu, Y. Zhang, C. Yuan*; “A new and convenient route to optically active 2-phosphoryl-3-oxo- 5-alkyl/aryl tetrahydrofurans and the reactions thereof” Eur. J. Org. Chem.2004, 2253-2262. 22. C. Xu, C. Yuan*; “Enzymatic synthesis of optically active 1-chloro-4-hydroxy-2-keto-alkane- phosphonates and reactions thereof” Tetrtahedron 2004,60, 3883-3892. 23. D. Gong, L. Zhang, C. Yuan*; “Synthesis of 4-(O,O-Dialkylphosphoryl)-1,3-Oxazole by Rhodium-catalyzed Hetereocycloaddition” Synth. Commun. 2004, 34, 3259-3264. 24. D. Gong, L. Zhang, C. Yuan*; “A Novel Route to 3-(O,O-Diethylphosphoryl)-2,3- dihydrofurans via Rhodium-catalyzed Hetereocycloaddition” Synth. Commun. 2004, 34, 3251-3258. 25. C. Xu, C. Yuan*; “A New Reaction System for Horner-Wadsworth-Emmons Olefination of Optically Active 4-Hydroxy-2-oxo-alkanephosphonates and 4-Hydroxy-1-chloro-2-oxo- alkanephosphonates with Aliphatic Aldehydes” Synthesis 2004, 2449-2458. 26. C. Xu, C. Yuan*; “A Facile Synthesis of Optically Active β-Amino-β-Arylethyl Phosphoates by Mitsunobu Reaction” Eur. J. Org. Chem. 2004, 4410-4415. 27. C. Xu, C. Yuan*; “An Improved Method for the synthesis of chiral Tomoxetine and fluoxines” Chin. J. Chem. 2004, 22, 775-778. 28. D. Gong, J. Li, C. Yuan*; “A New and Efficient Synthesis of Wedelolactone Derivatives” Chin. J. Chem. 2004, 22, 925-931. 29. D. Chen, P. Zhong, J. Ding and C. Yuan*; “(1RS,3aSR)-1-(chloromethyl)-1λ-5-Phospha-2,4a- Diazaperhydropentalene-1-oxide Dehydrate” Acta Cryst. 2004, E60, 237–238. 30. M.Kobori, Z. Yang, D. Gong, C. Yuan, J. Yuan*; “Wedelolactone Suppresses LPS-Induced Expression by Directly Inhibiting the IKK Complex”; Cell Death and Differetiation 2004, 11, 125-130.