2016.06-至今 中国科学院上海有机化学研究所金属有机化学国家重点实验室, 研究员 2012.11-2016.05 麻省理工学院化学系,博士后研究员（导师： Prof. Stephen L. Buchwald） 2011.10-2012.10 东京大学药学部, JSPS博士后研究员（导师： Prof. Motomu Kanai） 2008.10-2011.09 东京大学药学部, 博士（导师：Prof. Masakatsu Shibasaki and Prof. Motomu Kanai）

发展新型优势手性氮杂环卡宾配体；发展新型高效的不对称催化反应；发展经济、绿色和高效的手性药物及药物中间体合成新工艺

Lin-Xin Ruan, Bo Sun, Jia-Ming Liu,Shi-Liang Shi*Dynamic kinetic asymmetricarylation andalkenylation of ketones. Science 2023, 379, 662-670. Zi-Chao Wang#, Xiaohua Luo#, Jia-Wen Zhang#, Chen-Fei Liu#, Ming Joo Koh*, Shi-Liang Shi* Enantioselective C–C cross-coupling of unactivated alkenes. Nat. Catal. 2023, 6, 1087–1097. Zi-Chao Wang, Jia-Wen Zhang, Ming Joo Koh*, Shi-Liang Shi* Divergent and Selective Light Alkene Cross-Coupling. Angew. Chem. Int. Ed., 2023, 62, e202310203. inyang Jiang, Jia-ming Liu, Shi-Liang Shi* Bifunctional NHC-Promoted C2-Alkylation of Pyridine via Ni–Al Bimetallic-Catalyzed Hydroarylation of Unactivated Alkenes. ACS Catal. 2023, 13, 6068-6075. Zi-Chao Wang, Yan-Yu Li, Shuo-Qing Zhang, Xin Hong*, Shi-Liang Shi* Unsymmetric N-heterocyclic carbene ligand enabled nickel-catalysed arylation of bulky primary and secondary amines. Chem. Sci., 2023, 14, 4390-4396. Binyang Jiang, Shi-Liang Shi* C–H Functionalization of Arenes via NHC-Supported Ni/Al Bimetallic Catalysis. Synthesis, 2023, 55, 4049-4061. Yang Qin, Sheng Liu, Shi-Liang Shi* Transition-Metal-Free Cross-Coupling of Acetals and Grignard Reagents to Form Diarylmethyl Alkyl Ethers and Triarylmethanes. Synthesis, 2023, 55, DOI: 10.1055/a-2088-5000. Chen-Fei Liu#, Zi-Chao Wang#, Xiaohua Luo#, Jiawei Lu, Charyl Hui Min Ko, Shi-Liang Shi*, Ming Joo Koh* Synthesis of tri- and tetrasubstituted stereocentres by nickel-catalysed enantioselective olefin cross-couplings. Nat. Catal. 2022, 5, 934-942. Jun-Bao Ma, Xia Zhao, Dongju Zhang*, Shi-Liang Shi* Enantio- and Regioselective Ni-Catalyzed para-C-H Alkylation of Pyridines with Styrenes via Intermolecular Hydroarylation. J. Am. Chem. Soc. 2022, 144, 13643-13651. Wu-Bin Zhang, Guang Chen, Shi-Liang Shi* Enantioselective Ni/N-Heterocyclic Carbene-Catalyzed Redox-Economical Coupling of Aldehydes, Alkynes, and Enones for Rapid Construction of Acyclic All-Carbon Quaternary Stereocenters. J. Am. Chem. Soc.2022, 144, 130-136. Zi-Chao Wang, Jian Gao, Yuan Cai, Xiaodong Ye, Shi-Liang Shi* Chemo- and Enantioselective Arylation and Alkenylation ofAldehydes Enabled by Nickel/ N-Heterocyclic Carbene Catalysis. CCS Chem. 2022, 4, 1169-1179. Binyang Jiang, Shi-Liang Shi* Pd-Catalyzed Cross-Coupling of Alkylzirconocenes and Aryl Chlorides. Chin. J. Chem. 2022, 40, 1813-1820. Lei Gao, Sheng Liu, Zi-Chao Wang, Yongjun Mao*, Shi-Liang Shi* Ligand- and Additive-Free CuCl2 -Catalyzed para-C-H Alkylation ofAniline Derivatives via Carbene Insertion. Asian J. Org. Chem. 2022, 11, e202100723. Yurong Zhang, Han Wang*, Yongjun Mao, Shi-Liang Shi* Ni-Catalyzed Three-Component Coupling Reaction of Butadi-ene, Aldimines and Alkenylboronic Acids. Chin. J. Org. Chem. 2022, 42, 1198-1209. Binyang Jiang, Shi-Liang Shi* Recent Progress in Upgrading of Alcohol and Amine viaAsymmetric Dehydrogenative Coupling. Chin. J. Org. Chem. 2022, 42, 3263-3279. Yuan Cai, Shi-Liang Shi* Enantioconvergent Arylation of Racemic Secondary Alcohols to Chiral Tertiary Alcohols Enabled by Nickel/N-Heterocyclic Carbene Catalysis. J. Am. Chem. Soc. 2021, 143, 11963-11968. Zi-Chao Wang, Pei-Pei Xie, Youjun Xu, Xin Hong*, Shi-Liang Shi* Low-Temperature Ni-Catalyzed C-N Cross-Coupling via Kinetic Resolution Enabled by a Bulky yet Flexible Chiral N-Heterocyclic Carbene Ligand. Angew. Chem. Int. Ed. 2021, 60, 16077-16084. Yuan Cai, Lin-Xin Ruan, Abdul Rahman, Shi-Liang Shi* Fast Enantio- and Chemoselective Arylation of Ketones with Organoboronic Esters Enabled by Nickel/NHC Catalysis. Angew. Chem., Int. Ed. 2021, 60, 5262-5267. Yu-Qing Li, Guang Chen, Shi-Liang Shi* Regio- and Trans-Selective Ni-Catalyzed Coupling of Butadiene,Carbonyls, and Arylboronic Acids to Homoallylic Alcohols underBase-Free Conditions. Org. Lett. 2021, 23, 2571-2577. Yu-Qing Li, Shi-Liang Shi* Ni-Catalyzed Coupling of Butadiene, Aldimines, and ArylboronicAcids to Homoallylic Amines under Base-Free Conditions. Organometallics 2021, 40, 2345-2353. Yuan Cai, Shi-Liang Shi* ANIPE-Cu Catalyst Enables Highly Enantioselective Markovnikov Hydroboration of a-Olefins. Synlett 2021, 32, 545-550. Shichao Wei, Yongjun Mao*, Shi-Liang Shi* Nickel-Catalyzed Ligand-Free Hiyama Coupling of Aryl Bromides and Vinyltrimethoxysilane. Synlett 2021, 32, 1670-1674. Yu-Qing Li, Shi-Liang Shi* Nickel Catalyzed Multicomponent Coupling of Butadiene, Aldehydes, Alkynes, and Schwartz Reagent to Form 1,4 dienes. Chin. J. Org. Chem. 2021, 41, 1939-1948. Di Shen, Wu-Bin Zhang, Zhiyang Li, Shi-Liang Shi*, Youjun Xu* Nickel/NHC-Catalyzed Enantioselective Cyclization of Pyridones and Pyrimidones with Tethered Alkenes. Adv. Synth. Catal. 2020, 362, 1125-1130. Yu-Qing Li, Feng Li, Shi-Liang Shi* Expedient Synthesis of Ketones via N-Heterocyclic Carbene/Nickel-Catalyzed Redox-Economical Coupling of Alcohols and Alkynes. Chin. J. Chem. 2020, 38, 1035-1039. Zi-Chao Wang, Youjun Xu, Shi-Liang Shi* Base-Promoted Rapid Hydrosilylation of Aldimine. Chin. J. Org. Chem., 2020, 40, 3463-3466. Wu-Bin Zhang, Xin-Tuo Yang, Jun-Bao Ma, Zhi-Min Su, Shi-Liang Shi* Regio- and Enantioselective C-H Cyclization of Pyridines with Alkenes Enabled by a Nickel/N-Heterocyclic Carbene Catalysis. J. Am. Chem. Soc. 2019, 141, 5628-5634. Di Shen, Youjun Xu, Shi-Liang Shi* A Bulky Chiral N-Heterocyclic Carbene Palladium Catalyst Enables Highly Enantioselective Suzuki-Miyaura Cross-Coupling Reactions for the Synthesis of Biaryl Atropisomers. J. Am. Chem. Soc. 2019, 141, 14938-14945. Yuan Cai, Xiaodong Ye, Sheng Liu, Shi-Liang Shi* Nickel/NHC-Catalyzed Asymmetric C–H Alkylation of Fluoroarenes with Alkenes: Synthesis of Enantioenriched Fluorotetralins. Angew. Chem. Int. Ed. 2019, 58, 13433-13437. Yuan Cai, Jia-Wen Zhang, Feng Li, Jia-Ming Liu, Shi-Liang Shi* Nickel/N-Heterocyclic Carbene Complex-Catalyzed Enantioselective Redox-Neutral Coupling of Benzyl Alcohols and Alkynes to Allylic Alcohols. ACS Catal. 2019, 9, 1-6. Zi-Chao Wang, Di Shen, Jian Gao, Xian Jia, Youjun Xu*, Shi-Liang Shi* Base-Catalysed Reductive Relay Hydroboration of Allylic Alcohols with Pinacolborane to Form Alkylboronic Esters. Chem. Common., 2019, 55, 8848. (Invited Contribution to the ChemComm Emerging Investigators Issue 2019). Zi-Chao Wang, Min Wang, Jian Gao, Shi-Liang Shi,* Youjun Xu* nBuLi-Promoted anti-Markovnikov Selective Hydroboration of Unactivated Alkenes and Internal Alkynes. Org. Chem. Front. 2019, 6, 2949-2953. Feng Li, Xu Bai, Yuan Cai, Han Li, Shuo-Qing Zhang, Feng-Hua Liu, Xin Hong*, Youjun Xu* Shi-Liang Shi* Aluminum-Catalyzed Selective Hydroboration of Alkenes and Alkynylsilanes. Org. Process Res. Dev., 2019, 23, 1703-1708. Yuan Cai, Xin-Tuo Yang, Shuo-Qin Zhang, Feng Li, Yu-Qin Li, Lin-Xin Ruan, Xin Hong*, Shi-Liang Shi* Copper-Catalyzed Enantioselective Markovnikov Protoboration of a-Olefins Enabled by a Buttressed N-Heterocyclic Carbene Ligand. Angew. Chem. Int. Ed. 2018, 57, 1376-1380. Yuan Cai, Feng Li, Yu-Qing Li, Wu-Bin Zhang, Feng-Hua Liu*, Shi-Liang Shi* Base metal-catalyzed alcohol C–C couplings under hydrogen transferconditions. Tetrahedron Lett. 2018, 59, 1073–1079. Shi-Liang Shi, Zackary L. Wong, Stephen L. Buchwald* Copper-Catalyzed Enantioselective Stereodivergent Synthesis of Amino Alcohols. Nature 2016, 532, 353. Shi-Liang Shi, Stephen L. Buchwald* Copper-catalysed Selective Hydroamination Reactions of Alkynes. Nature Chemistry 2015, 7, 38. (Highlighted in Nature. Nature 517, 280.) Yang Yang#, Shi-Liang Shi#, Dawen Niu, Peng Liu, Stephen L. Buchwald* Catalytic Asymmetric Hydroamination of Unactivated Internal Olefins to Aliphatic Amines. Science 2015, 349, 62.