工作经历 2003年8月至今：任中国科学院研究员，上海有机化学研究所，研究员 2001年9月至2003年7月：美国威斯康星大学麦迪逊分校药学院，研究助理 2000年9月至2001年8月：美国加州大学戴维斯分校化学系，博士后 教育背景 1994年9月至2000年8月：中国协和医科大学（中国医学科学院）获硕士（1997年）、博士学位（2000年，美国加州大学戴维斯分校化学系联合培养），导师：李元教授、沈奔教授 1988年9月至1992年7月：四川大学生物工程系，获学士学位

复杂天然产物的生物合成（遗传学、生物化学和化学）研究 以产量提高和结构多样性为目的组合生物合成研究 以基因组扫描为手段的新型天然产物发现研究

Botao Cheng#, Jiwu Huang#, Yuting Duan, Wen Liu*. Association of radical chemistry with LanD flavoprotein activity for C-terminal macrocyclization of a ribosomal peptide through the formation of an unsaturated thioether residue. Angewandte Chemie-International Edition 2023, 62(35), e202308733. Zhijun Tang#, Bo Pang#, Chang Liu#, Shengjie Guo, Xudong Qu, Wen Liu*. Formation and loading of a (2S)-2-ethylmalonamyl starter unit in the assembly line of polyketide-nonribosomal peptide hybrid sanglifehrin A. Angewandte Chemie-International Edition 2023, 62(23), e202217090. Hongbo Wang#, Yike Zou#, Miao Li#, Zhijun Tang#, Jiabao Wang, Zhenhua Tian, Nina Strassner, Qian Yang, Qingfei Zheng, Yujiao Guo, Wen Liu*, Lifeng Pan*, K. N. Houk*. A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions. Nature Chemistry 2023, 15(2), 177-184. Yiyuan Cheng, Xuan Yi, Yan Zhang, Qingli He, Dandan Chen, Weiguo Cao, Pengfei Fang*, Wen Liu*. Oxidase heterotetramer completes 1？azabicyclo[3.1.0]hexane formation with the association of a nonribosomal peptide synthetase. Journal of the American Chemical Society 2023, 145(16), 8896-8907. Yanqing Xue#, Xiaofeng Wang#, Wen Liu*. Reconstitution of the linaridin pathway provides access to the family-determining activity of two membrane-associated proteins in the formation of structurally underestimated cypemycin. Journal of the American Chemical Society 2023, 145(12), 7040-7047. Shengjie Guo, Yueqian Sang, Chao Zheng, Xiao-Song Xue, Zhijun Tang*, Wen Liu*. Enzymatic α？ketothioester decarbonylation occurs in the assembly line of barbamide for skeleton editing. Journal of the American Chemical Society 2023, 145(9), 5017-5028. Ling Hu, Yi Qiao, Jingyu Liu, Chao Zheng, Xiaofeng Wang, Peng Sun, Yucheng Gu, Wen Liu*. Characterization of histidine functionalization and its timing in the biosynthesis of ribosomally synthesized and posttranslationally modified thioamitides. Journal of the American Chemical Society 2022, 144(10), 4431-4438. Bo Li, Xingyi Guan, Song Yang, Yike Zou, Wen Liu*, K. N. Houk*. Mechanism of the stereoselective catalysis of Diels？Alderase PyrE3 involved in pyrroindomycin biosynthesis. Journal of the American Chemical Society 2022, 144(11), 5099-5107. Sili Wang, Yiyuan Cheng, Xiaofeng Wang, Qian Yang, Wen Liu*. Tracing of acyl carrier protein-channeled mitomycin intermediates in Streptomyces caespitosus facilitates characterization of the biosynthetic steps for AHBA？GlcN formation and processing. Journal of the American Chemical Society 2022, 144(33), 14945-14956. Zhi Lin#, Yufeng Xue#, Xiao-Wei Liang, Jian Wang, Shuangjun Lin, Jiang Tao, Shu-Li You*, Wen Liu*. Oxidative indole dearomatization for asymmetric furoindoline synthesis by a flavin-dependent monooxygenase involved in the biosynthesis of bicyclic thiopeptide thiostrepton. Angewandte Chemie-International Edition 2021, 60(15), 8401-8405. Bo Pang#, Rijing Liao#, Zhijun Tang#, Shengjie Guo, Zhuhua Wu, Wen Liu*. Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2'-bipyridine formation. Nature Communications 2021, 12, 3124. Botao Cheng#, Heng Guo#, Haoyang Wang, Qunfei Zhao, Wen Liu*. Dissection of the enzymatic process for forming a central imidazopiperidine heterocycle in the biosynthesis of a series c thiopeptide antibiotic. Journal of the American Chemical Society 2021, 143(34), 13790-13797. Zhijun Tang#; Haoyu Tang#, Wanqiu Wang#, Yufeng Xue, Dandan Chen, Weihua Tang*, Wen Liu*. Biosynthesis of a new fusaoctaxin virulence factor in Fusarium graminearum relies on a distinct path to form a guanidinoacetyl starter unit priming nonribosomal octapeptidyl assembly. Journal of the American Chemical Society 2021, 143(47), 19719-19730. Yanping Qiu#, Jingyu Liu#, Yuping Li, Yanqing Xue, Wen Liu*. Formation of an aminovinyl-cysteine residue in thioviridamides occurs through a path independent of known lanthionine synthetase activity. Cell Chemical Biology 2021, 28(5), 675-685. Yanan Du#, Yanping Qu#, Xiang Meng, Junyin Feng, Jiang Tao, Wen Liu*. A heterotrimeric dehydrogenase complex functions with 2 distinct YcaO proteins to install 5 azole heterocycles into 35-membered sulfomycin thiopeptides. Journal of the American Chemical Society 2020, 142(18), 8454-8463. Yike Zou, Song Yang, Jacob N. Sanders, Wei Li, Peiyuan Yu, Hongbo Wang, Zhijun Tang, Wen Liu*, K. N. Houk*. Computational investigation of the mechanism of Diels-Alderase PyrI4. Journal of the American Chemical Society 2020, 142(47), 20232-20239. Daozhong Zhang, Fang Zhang, Wen Liu*. A KAS-III heterodimer in lipstatin biosynthesis nondecarboxylatively condenses C8 and C14 fatty acyl-CoA substrates by a variable mechanism during the establishment of a C22 aliphatic skeleton. Journal of the American Chemical Society 2019, 141(9), 3993-4001. Daozhong Zhang, Zhijun Tang, Wen Liu*. Biosynthesis of lincosamide antibiotics: reactions associated with degradation and detoxification pathways play a constructive role. Accounts of Chemical Research 2018, 51(6), 1496-1506. Qingfei Zheng#, Yukang Gong#, Yujiao Guo, Zhixiong Zhao, Zhuhua Wu, Zixuan Zhou, Dandan Chen, Lifeng Pan*, Wen Liu*. Structural insights into a flavin-dependent [4+2] cyclase that catalyzes trans-decalin formation in pyrroindomycin biosynthesis. Cell Chemical Biology 2018, 25(6), 718-727. Jingjing Li, Yue Li, Guoqing Niu, Heng Guo, Yanping Qiu, Zhi Lin, Wen Liu*, Huarong Tan*. NosP-regulated nosiheptide production responds to both peptidyl and small-molecule ligands derived from the precursor peptide. Cell Chemical Biology 2018, 25(2), 143-153.