1978年毕业于上海第一医学院药学系。在上海第一医学院药学系药物化学教研组工作二年后于1980年考入中国科学院上海有机化学研究所，师从黄乃正教授（现在香港中文大学化学系）和黄维垣教授进行研究生学习，1986年获理学博士学位，1987年11月至1989年10月在德国科隆大学Vogel小组从事博士后研究。1989年回到上海有机化学研究所。现任上海有机化学研究所研究员，博士生导师，中国科学院金属有机化学国家重点实验室副主任，（香港大学，香港中文大学，上海有机化学研究所共同组建的）沪港化学合成联合实验室副主任。

导向有机合成的金属有机化学；手性配体的设计，合成及在不对称催化中的应用；小环化合物的转化

Yan, X. X.; Liang, C. G.; Zhang, Y.; Hong, W.; Cao, B. X.; Dai, L. X.; Hou, X. L.*, Highly Enantioselective Pd-Catalyzed Allylic Alkylation of Acyclic Ketones, Angew. Chem. Int. Ed. 2005, 44, 6544-6546. Xiao-Xia Yan, Qian Peng, Yan Zhang, Kai Zhang, Wei Hong, Xue-Long Hou* and Yun-Dong Wu, A Highly Enantio- and Diastereoselective Cu-Catalytic 1,3-Dipolar Cycloaddition of Azomethine Ylides with Nitroalkenes, Angew. Chem. Int. Ed. 2006, 45, 1979-1983. Zheng, W.-H.; Zheng, B.-H.; Zhang, Y.; Hou, X.-L.*, Highly Regio-, Diastereo- and Enantioselective Pd-Catalyzed Allylic Alkylation of Acyclic Ketone Enolates with Monosubstituted Allyl Substrates, J. Am. Chem. Soc. 2007, 129, 7718-7719. Zhang, K.; Peng, Q.; Hou, X.-L.*; Wu, Y.-D., Highly Enantioselective Palladium-Catalyzed alkylation of Acyclic Amides, Angew. Chem. Int. Ed. 2008, 47, 1741. Wen-Qiong Wu, Qian Peng, Da-Xuan Dong, Xue-Long Hou* and Yun-Dong Wu*, A Dramatic Switch of Enantioselectivity in Asymmetric Heck Reaction by Benzylic Substituents of Ligands,J. Am. Chem. Soc. 2008, 129, 9717-9725. Xiao Xia Yan, Qian Peng, Qing Li, Kai Zhang, Jun Yao, Xue Long Hou*, Yun Dong Wu*, Highly Diastereoselectivity Switchable Enantioselective Mannich Reaction of Glycine Derivatives with Imines, J. Am. Chem. Soc. 2008, 130, 14362-14363. Wei Jing Lu, Yun Wei Chen, Xue Long Hou*, Iridium-Catalyzed Highly Enantioselective Hydrogenation of the C=C bond of α, β-Unsaturated Ketones, Angew. Chem. Int. Ed. 2008, 47, 10133-10136. Wei Liu, Di Chen, Xia-Zhen Zhu, Xiao-Long Wan and Xue-Long Hou*, Highly Diastereo- and Enantioselective Pd-Catalyzed Cyclopropanation of Acyclic Amides with Substituted Allyl Carbonates, J. Am. Chem. Soc. 2009, 131, 8734-8735. Lei, B.-L.; Ding, C.-H.; Yang, X.-F.; Wan, X.-L.; and Hou, X.-L.*, Highly Efficient Kinetic Resolution of 2-Substituted-2,3-Dihydro-4-Quinolones by Palladium-Catalyzed Asymmetric Allylic Alkylation, J. Am. Chem. Soc. 2009, 131, 18250-18251. Hai-Lin Liu, Di Chen, Xue-Long Hou*, Michal Sabat, and Lin Pu*, Highly Enantioselective Recognition of Structurally Diverse a-Hydroxycarboxylic Acids by a Fluorescent Sensor, Angew. Chem. Int. Ed. 2010, 49, 602-606.