2002年7月毕业于浙江大学医学院临床医学系，获得MD。2006年7月毕业于中国医学科学院中国协和医科大学，获得PhD。2006年至2010年在美国哈佛大学医学院波士顿儿童医院从事博士后研究。2009年任哈佛大学医学院讲师和Research Associate。2010年9月至2016年8月任中国科学院上海生命科学研究院营养科学研究所研究员，研究组长。2016年9月起任职于中国科学院上海生命科学研究院生物化学与细胞生物学研究所研究员，研究组长。曾获得国家杰出青年科学基金、ISHR杰出研究员奖、“英国皇家学会-牛顿高级学者基金”、中国青年科技奖、中国科学院青年科学家奖、谈家桢生命科学创新奖、树兰医学青年奖等。

研究体内特定类型细胞的起源及命运，揭示细胞在发育、疾病和组织再生中的分化或转分化现象（细胞命运可塑性）及细胞命运调控机制具有重大的科学意义。研究组主要利用基于同源重组酶系统的遗传谱系追踪技术（图），在哺乳动物体内进行细胞标记及追踪来研究细胞的起源及命运。此外，研究组长期致力于谱系追踪新技术的开发及应用，并利用新技术更加深入探索哺乳动物体内细胞命运可塑性及其分子机制

Tang J, Wang H, Huang X, Li F, Zhu H, Li Y, He L, Zhang H, Pu W, Liu K, Zhao H, Bentzon JF, Yu Y, Ji Y, Nie Y, Tian X, Zhang L, Gao D, Zhou B*. Arterial Sca1+ vascular stem cells generate de novo smooth muscle for artery repair and regeneration. Cell Stem Cell 2019; in press Zhao H, Li Y, He L, Pu W, Yu W, Li Y, Wu Y, Xu C, Wei Y, Ding Q, Song BL, Huang H, Zhou B*. In vivo AAV-CRISP/Cas9-mediated gene editing ameliorates atherosclerosis in familial hypercholesterolemia. Circulation 2019; in press He L, Han M, Zhang Z, Li Y, Huang X, Liu X, Pu W, Zhao H, Wang Q, Nie Y, Zhou B*. Reassessment of c-Kit Cells for Cardiomyocyte Contribution in Adult Heart. Circulation 2019;140:164-166. Feng T, Meng J, Kou S, Jiang Z, Huang X, Lu Z, Zhao H, Lau LF, Zhou B*, Zhang H*. CCN1-Induced Cellular Senescence Promotes Heart Regeneration. Circulation 2019;139:2495-2498. Liu Q, Liu K, Cui G, Huang X, Yao S, Guo W, Qin Z, Li Y, Yang R, Pu W, Zhang L, He L, Zhao H, Yu W, Tang M, Tian X, Cai D, Nie Y, Hu S, Ren T, Qiao Z, Huang H, Zeng YA, Jing N, Peng G, Ji H, Zhou B*. Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nat Genet 2019;51:728-738. Li Y, Lv Z, He L, Huang X, Zhang S, Zhao H, Pu W, Li Y, Yu W, Zhang L, Liu X, Liu K, Tang J, Tian X, Wang Q-D, Lui KO, Zhou B*. Genetic Tracing Identifies Early Segregation of the Cardiomyocyte and Nonmyocyte Lineages. Circ Res 2019;125:343-355. Ni Z, Deng J, Potter CMF, Nowak WN, Gu W, Zhang Z, Chen T, Chen Q, Hu Y, Zhou B, Xu Q, Zhang L*. Recipient c-Kit Lineage Cells Repopulate Smooth Muscle Cells of Transplant Arteriosclerosis in Mouse Models. Circ Res 2019;125:223-241. Zhang X, Zhang H, Xu C, Li X, Li M, Wu X, Pu W, Zhou B, Wang H, Li D, Ding Q, Ying H, Wang H, Zhang H*. Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis. Nat Commun 2019;10:4158. Akerberg BN, Gu F, VanDusen NJ, Zhang X, Dong R, Li K, Zhang B, Zhou B, Sethi I, Ma Q, Wasson L, Wen T, Liu J, Dong K, Conlon FL, Zhou J, Yuan GC, Zhou P, Pu WT*. A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers. Nat Commun 2019;10:4907. Wei X, Guo J, Li Q, Jia Q, Jing Q, Li Y, Zhou B, Chen J, Gao S, Zhang X, Jia M, Niu C, Yang W, Zhi X, Wang X, Yu D, Bai L, Wang L, Na J, Zou Y, Zhang J, Zhang S, Meng D*. Bach1 regulates self-renewal and impedes mesendodermal differentiation of human embryonic stem cells. Sci Adv 2019;5:eaau7887. Liu X, Chen W, Li W, Li Y, Priest JR, Zhou B, Wang J, Zhou Z*. Single-Cell RNA-Seq of the Developing Cardiac Outflow Tract Reveals Convergent Development of the Vascular Smooth Muscle Cells. Cell Rep 2019;28:1346-1361.e4. Zhao H, Zhou B*. Dual genetic approaches for deciphering cell fate plasticity in vivo: more than double. Current Opinion in Cell Biology 2019;61:101-109. Li Y, He L, Huang X, Issa Bhaloo S, Zhao H, Zhang S, Pu W, Tian X, Li Y, Liu Q, Yu W, Zhang L, Liu X, Liu K, Tang J, Zhang H, Cai D, Adams RH, Xu Q, Lui KO, Zhou B*. Genetic Lineage Tracing of Non-Myocyte Population by Dual Recombinases. Circulation 2018;138:793-805. Tang J, Li Y, Huang X, He L, Zhang L, Wang H, Yu W, Pu W, Tian X, Nie Y, Hu S, Wang Q-D, Lui KO, Zhou B*. Fate Mapping of Sca1 Cardiac Progenitor Cells in the Adult Mouse Heart. Circulation 2018;138:2967-2969. Zhang H, Lui KO, Zhou B*. Endocardial Cell Plasticity in Cardiac Development, Diseases and Regeneration. Circ Res 2018;122:774-789. Zhou B*, Wu SM*. Reassessment of c-Kit in Cardiac Cells: A Complex Interplay Between Expression, Fate, and Function. Circ Res 2018;123:9-11. Pu W, He L, Han X, Tian X, Li Y, Zhang H, Liu Q, Huang X, Zhang L, Wang QD, Yu Z, Yang X, Smart N, Zhou B*. Genetic Targeting of Organ-Specific Blood Vessels. Circ Res 2018;123:86-99. Zhang L, Issa Bhaloo S, Chen T, Zhou B*, Xu Q*. Role of Resident Stem Cells in Vessel Formation and Arteriosclerosis. Circ Res 2018;122:1608-1624. Zhao ZA, Han X, Lei W, Li J, Yang Z, Wu J, Yao M, Lu XA, He L, Chen Y, Zhou B, Hu S*. Lack of Cardiac Improvement After Cardiosphere-Derived Cell Transplantation in Aging Mouse Hearts. Circ Res 2018;123:e21-e31. Zhao H, Tian X, He L, Li Y, Pu W, Liu Q, Tang J, Wu J, Cheng X, Liu Y, Zhou Q, Tan Z, Bai F, Xu F, Smart N, Zhou B*. Apj+ Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target. Cell Rep 2018;25:1241-1254.e5.