杨巍维 照片

杨巍维

研究员

所属大学: 中国科学院上海生物化学与细胞生物研究所

所属学院: 未知

邮箱:
weiweiyang@@sibcb.ac.cn

个人主页:
http://www.sibcb.ac.cn/PI.asp?id=151

个人简介

2001年获武汉大学学士学位,2007年获中科院上海生科院健康科学研究所博士学位,2008至2013年在美国安德森癌症中心(MD Anderson Cancer Center)做博士后研究,并成为奥德赛学者(Odyssey Fellow)。2013年8月起担任中科院生物化学与细胞生物学研究所研究员,研究组长,博士生导师

研究领域

1、癌症等重大疾病的代谢重编程机制 2、代谢小分子新功能 3、肿瘤微环境与肿瘤细胞代谢的交互调控

近期论文

Wang X, Liu R, Zhu W, Qu X, Yu H, Chu H, Zhang Y, Zhu W, Wu X, Gao H, Tao B, Li W, Liang J, Li G*, Yang W*. α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development. Molecular Cell, 2019 Aug 22;DOI:https://doi.org/10.1016/j.molcel.2019.07.007 Wang X, Liu R, Zhu W, Chu H, Yu H, Wei P, Wu X, Zhu H, Gao H, Liang J, Li G, Yang W*. UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis. Nature; 2019 Jul; 571(7763):127-131. Liu R, Li W, Tao B, Wang X, Yang Z, Zhang Y, Wang C, Liu R, Gao H, Liang J, Yang W*. Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance. Nat Commun, 2019 Mar 1; 10(1):991. Jin G, Zhang Y, Cong W, Wu X, Wang X, Wu S, Wang S, Zhou W, Yuan S, Gao H, Yu G, Yang W*. Phosphoglucomutase 1 Inhibits Hepatocellular Carcinoma Progression by Regulating Glucose Trafficking. PLOS Biol, 2018, 16(10): e2006483. Zhang Y, Yu G, Chu H, Wang X, Xiong L, Cai G, Liu R, Gao H, Tao B, Li W, Li G, Liang J, Yang W*. Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis. Mol Cell, 2018 July; 71:1-15 Liang J, Cao R, Wang X, Zhang Y, Wang P, Gao H, Li C, Yang F, Zeng R, Wei P, Li D, Li W and Yang W*. Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2. Cell Res, 2017 Mar; 27(3):329-351. Liang J, Cao R, Zhang Y, Xia Y, Zheng Y, Li X, Wang L, Yang W*, Lu Z*. PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis. Nat Commun, 2016 Aug 3; 7:12431. Yang W, Zheng Y, Xia Y, Ji H, Cote G, Aldape K, Chen X, Lu Z*. ERK1/2-dependent nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol, 2013 Jan; 15(1):124. Yang W, Xia Y, Zheng Y, Bu W, Yung W, Cote G, Aldape K, Li Y, Verma I, Chiao P, Lu Z*. EGFR-induced NF-kB activation upregulates PKM2 expression and promotes the Warburg effect. Mol Cell, 2012 Dec 14; 48(5):771-84. Yang W, Xia Y, Hawke D, Li X, Liang J., Xing D, Aldape K, Hunter T, Yung W, Lu Z*. PKM2 phosphorylates Histone H3 and promotes gene transcription and tumorigenesis. Cell, 2012 Aug 17; 150(4):685-96. Yang W, Xia Y, Ji H, Zheng Y., Liang J., Huang W, Gao X, Aldape K, and Lu Z*. Nuclear PKM2 regulates beta-catenin transactivation upon EGF stimulation. Nature, 2011 Dec 1; 480(7375):118-22.