2000年毕业于上海第二医科大学，获博士学位。2001年2月至2004年1月在美国University of Pennsylvania从事博士后研究；2004年2月起在美国Northwestern University从事博士后研究，于2005年1月起任助理教授(研究型)；2009年至2013年受聘于美国Washington State University，先后为助理教授(研究型)和副教授(研究型)。现任中国科学院上海生命科学院生物化学与细胞生物学研究所研究员、研究组长

1.减数分裂启动和发展的调控机制：绘制哺乳动物减数分裂启动和发展过程中RNA（mRNA和非编码RNA）和蛋白质动态变化和其修饰图谱及其调控的酶系图谱，揭示这种动态变化及其修饰发生的分子基础。 2.减数分裂启动和发展的表观遗传调控机制：以 RNA甲基化、组蛋白修饰和染色质重塑为重点，阐明哺乳动物减数分裂启动和发展过程中的表观遗传变化及其机制。 3.微环境对减数分裂启动和发展的作用及其机制 4.减数分裂体外重建技术： 建立包括人精原干细胞在内的精原细胞培养、体外分化及减数分裂的技术平台，实现在培养皿中培养获取单倍体精子细胞

Yao Chen, Yuxuan Zheng, Yun Gao, Zhen Lin, Suming Yang, Tongtong Wang, Qiu Wang, Nannan Xie, Rong Hua,Mingxi Liu, Jiahao Sha, Michael D. Griswold, Jinsong Li*, Fuchou Tang* and Ming-Han Tong* 2018 Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis. Cell Research. [Epub ahead of print] (Cover paper) *Corresponding author. (Highlighted by NSR) Xiaoli Zuo, Bowen Rong, Li Li, Ruitu Lv, Fei Lan*, and Ming-Han Tong* 2018 The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice. Journal of Biological Chemistry. 293(24) 9188-9197 PMID: 29716999 *Corresponding author Tongtong Wang, Qianqian Yin, Xuehao Ma, Ming-Han Tong*, Yuchuan Zhou* 2018 Ccdc87 is critical for sperm function and male fertility. Biol Reprod. [Epub ahead of print] PMID: 29733332 *Corresponding author Zhen Lin,Phillip J Hsu,Xudong Xing,Jianhuo Fang,Zhike Lu,Qin Zou,Ke-Jia Zhang,Xiao Zhang,Yuchuan Zhou,Teng Zhang,Youcheng Zhang,Wanlu Song,Guifang Jia, Xuerui Yang*,Chuan He*,Ming-Han Tong* 2017 Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis.Cell Research. 27(10): 1216-1230 PMID: 28914256 *Corresponding author. (Highlighted by NSR) Yao Chen,Li Ma,Cathryn Hogarth,Gang Wei,Michael D. Griswold*Ming-Han Tong* 2016 Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes. Development. 143(9): 1502-1511 PMID: 26965368 *Corresponding author. (Highlighted article) Tong, Ming-han* Li, Jinsong* 2015 Similarity of epigenetic reprogramming in primordial germ cells between human and mouse. National Science Review.12, 2(4): 384 *Corresponding author Ming-Han Tong*, Qi-En Yang, Jeffrey C. Davis, and Michael D. Griswold* 2013 Retinol dehydrogenase 10 is indispensible for spermatogenesis in juvenile males. ProcNatlAcadSci U S A. 110(2): 543-8 PMID: 23267101 * Corresponding author Ming-Han Tong*, Debra Mitchell, Samantha McGowan and Michael D.Griswold* 2012 Two miRNAs Clusters, Mir-17-92 and Mir-106b-25, Are Involved in the Regulation of Spermatogonial Differentiation. Biol Reprod. 86(3): 72 1-10 PMID: 22116806 * Corresponding author Ming-Han Tong, Debra Mitchell, Ryan Evanoff and Michael D.Griswold 2011 Expression of Mirlet7 Family MicroRNAs in Response to Retinoic Acid-Induced Spermatogonial Differentiation in Mice. Biol Reprod. 85 (1): 189-97 PMID: 21430230 Tong MH, Jiang H, Liu P, Lawson JA, Brass LF, Song WC. 2005 Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice. Nat Med. 11(2): 153-9 PMID: 15685171