Activation of small C1 molecules (CO and CO2) and inert chemical bonds (C–H and C–N) and their catalytic transformation Discovery of new synthetic methodologies and their applications in the synthesis of biologically active small molecules

Xia, J.-B.; You, S.-L. ‘‘C–C Bond Formation by Double C–H Bond Activation’’, in Science of Synthesis, Yu, J.-Q., Ed, Thieme, Stuttgart, 2015, in press. Xia, J.-B.; Zhu, C.; Chen, C. “Visible Light-Promoted Metal-Free sp3-C–H Fluorination” Chem. Commun. 2014, 50, 11701-11704. Xia, J.-B.; Ma, Y.; Chen, C. “Vanadium-Catalyzed C(sp3)–H Fluorination Reactions” Org. Chem. Front. 2014, 1, 468-472. Zhu, C.; Xia, J.-B.; Chen, C. “A Simple Method for the Electrophilic Cyanation of Secondary Amines” Org. Lett. 2014, 16, 247-250. Zhu, C.; Xia, J.-B.; Chen, C. “Vanadium-Catalyzed Oxidative Strecker Reaction: α-C–H Cyanation of para-Methoxyphenyl (PMP)-Protected Primary Amines” Tetrahedron Lett. 2014, 55, 232-234. Xia, J.-B.; Zhu, C.; Chen, C. “Visible Light-Promoted Metal-Free C–H Activation: Diarylketone-Catalyzed Selective Benzylic Mono- and Difluorination” J. Am. Chem. Soc. 2013, 135, 17494-17500. · Highlighted in Synfacts 2014, 10, 85. Xia, J.-B.; Cormier, W. K.; Chen, C. “A Highly Selective Vanadium Catalyst for Benzylic C–H Oxidation” Chem. Sci. 2012, 3, 2240-2245. Liu, W.-B.; Xia, J.-B.; You, S.-L. “Iridium-Catalyzed Asymmetirc Allylic Substitutions” Top. Organomet. Chem. 2012, 38, 155-208. Xia, J.-B.; Liu, W.-B.; Wang, T.-M.; You, S.-L. “Enantioselective Synthesis of 3-Azabicyclo[4.1.0]heptanes and 3-Azabicyclo[3.2.0]heptanes via Ir-Catalyzed Asymmetric Allylic Amination of N-Tosyl Propynylamine and Pt-Catalyzed Cycloisomerization Reaction” Chem. Eur. J. 2010, 16, 6442-6446. Highlighted in Synfacts 2010, 8, 909. You, S.-L.; Xia, J.-B. ; ‘‘Palladium-Catalyzed Aryl–Aryl Bond Formation through Double C–H Activation’’ Top. Curr. Chem. 2010, 292, 165-194. Xia, J.-B.; Jamison, T. F.; You, S.-L. ‘‘Monodentate Chiral Ferrocenyl Ligands’’, in Chiral Ferrocenes in Asymmetric Catalysis: Synthesis and Applications, Dai, L.-X., Hou, X.-L., Eds, WILEY-VCH, Weinheim, 2010, pp. 55-71. Xia, J.-B.; Zhuo, C.-X.; You, S.-L. “Synthesis of Cyclopropane-containing Building Blocks via Ir-Catalyzed Enantioselective Allylic Substitution Reaction” Chin. J. Chem. 2010, 28, 1525-1528. Xia, J.-B.; You, S.-L. ‘‘Synthesis of 3-Haloindolizines by Copper(II) Halides Mediated Direct Functionalization of Indolizines’’ Org. Lett. 2009, 11, 1187-1190. Xia, J.-B.; Wang, X.-Q.; You, S.-L. ‘‘Synthesis of Biindolizines through Highly Regioselective Palladium-Catalyzed C–H Functionalization’’ J. Org. Chem. 2009, 74, 456-458. Wang, X.-Q.; Xia, J.-B.; Dai, X.-Y.; You, S.-L. ‘‘Preparation of Ferrocenyl Imidazolines using Bis(triphenyl)oxodiphosphonium Trifluoromethansulfonate” Sci. China Chem. 2009, 52, 1331-1336. Xia, J.-B.; You, S.-L. ‘‘Carbon–Carbon Bond Formation through Double sp2 C–H Activations: Synthesis of Ferrocenyl Oxazoline Derivatives’’ Organometallics 2007, 26, 4869-4871.