黎胜红
研究员 博导
个人简介
教育背景 1996-09--2001-08 中国科学院昆明植物研究所 博士学位 1992-09--1996-07 云南大学 学士学位 工作简历 2007-08~现在, 中国科学院昆明植物研究所, 研究员、引进国外杰出人才 2004-10~2008-01,德国马普化学生态研究所, 博士后（兼洪堡研究学者） 2004-03~2004-09,香港中文大学中医中药研究所, 博士后 2003-04~2004-02,中国科学院昆明植物研究所, 副研究员 2001-09~2003-03,中国科学院昆明植物研究所, 助理研究员
研究领域
植物天然产物化学、生物功能与生物合成：主要运用植物化学、分析化学、生物化学、细胞和分子生物学等手段，以及首创单细胞植物化学研究新技术方法LMD-cryoNMR-UPLC/MS/MS，揭示植物特殊结构（如腺毛、特定细胞等）中的天然产物及其生物功能，在此基础上发现独特天然活性物质，对具有新颖结构和重要生物功能的天然产物开展其生物合成和作用机理等研究。
近期论文
Mu, RongFang, Hua, Juan, Li, Dan, Luo, ShiHong, Chen, YueGui, Jing, ShuXi, Liu, Yan, Li, ShengHong. Nematicidal Activity of 20-Deoxyingenol-3-angelate from Euphorbia peplus Latex Through Protein Kinase C Isotype TPA-1. Journal of Agricultural and Food Chemistry[J]. 2024, 第 8 作者 通讯作者 Li, Man, Feng, Ling, Zhang, Han, Liu, YanChun, Zhou, TingTing, Zheng, Yu, Guo, Kai, Liu, Yan, Li, ShengHong. Unusual immunosuppressive pyridine-containing bisnor- (c23), tetranor- (c21) and pentanor- (c20) sesterterpenoids from Tibetan Leucosceptrum canum. Organic & Biomolecular Chemistry[J]. 2024, 第 9 作者 通讯作者 Li, Tao, Li, Hao, Zhou, TingTing, Zheng, Yu, Li, ShengHong. Syntheses of Linear Biosynthetic C25-Precursors of Leucosceptroids. Journal of Organic Chemistry[J]. 2024, 第 5 作者 通讯作者 Yang, MinJie, Luo, ShiHong, Guo, Kai, Liu, Yan, Li, ShengHong. Chemical investigation of Buddleja officinalis leaves and localization of defensive triterpenoids to its glandular trichomes. Fitoterapia[J]. 2023, 第 5 作者 通讯作者 164: http://dx.doi.org/10.1016/j.fitote.2022.105379. Chen, Yonghong, Yang, Xiaoyu, Zhang, Longlong, Wu, Qunfu, Li, Shuhong, Gou, Jianghui, He, Jiangbo, Zhang, Keqin, Li, Shenghong, Niu, Xuemei. Tryptophan-centered metabolic alterations coincides with lipid-mediated fungal response to cold stress. Heliyon[J]. 2023, 第 9 作者 通讯作者 9(2): e13066, http://dx.doi.org/10.1016/j.heliyon.2023.e13066. Chen, Yuegui, Yan, Qin, Ji, Yunheng, Bai, Xue, Li, Desen, Mu, Rongfang, Guo, Kai, Yang, Minjie, Tao, Yang, Jonathan Gershenzon, Liu, Yan, Li, Shenghong. Unraveling the serial glycosylation in the biosynthesis of steroidal saponins in the medicinal plant Paris polyphylla and their antifungal action. Acta Pharmaceutica Sinica B[J]. 2023, 第 12 作者 通讯作者 Liu, Yan, Zhou, YanYing, Luo, ShiHong, Guo, Kai, Zhang, ManWen, Jing, ShuXi, Li, ChunHuan, Hua, Juan, Li, ShengHong. Labdane diterpenoids from the heartwood of Leucosceptrum canum that impact on root growth and seed germination of Arabidopsis thaliana. Phytochemistry[J]. 2023, 第 9 作者 通讯作者 206: http://dx.doi.org/10.1016/j.phytochem.2022.113531. Yang, Xiaoyu, Chen, Yonghong, Zhang, Longlong, He, Jiangbo, Wu, Qunfu, Li, Shuhong, Wang, Donglou, Gou, Jianghui, Wu, Zhuang, Zhang, Keqin, Li, Shenghong, Niu, Xuemei. Melanin precursors mediated adaption to temperature changes in fungus and animal via inhibition of lipid-mediated ferroptosis. Science China Life Sciences[J]. 2023, 第 11 作者 通讯作者 Li, Desen, Yang, Minjie, Mu, Rongfang, Luo, Shihong, Chen, Yuegui, Li, Wenyuan, Wang, An, Guo, Kai, Liu, Yan, Li, Shenghong. Characterization of two chimeric sesterterpene synthases from a fungal symbiont isolated from a sesterterpenoid-producing Lamiaceae plant Leucosceptrum canum. Chinese Chemical Letters[J]. 2023, 第 10 作者 通讯作者 34(1): 279-283, http://dx.doi.org/10.1016/j.cclet.2022.04.067. Li, Desen, Shi, Linlin, Guo, Kai, Luo, Shihong, Liu, Yanchun, Chen, Yuegui, Liu, Yan, Li, Shenghong. A new sesquiterpene synthase catalyzing the formation of (R)-β-bisabolene from medicinal plant Colquhounia coccinea var. mollis and its anti-adipogenic and antibacterial activities. Phytochemistry[J]. 2023, 第 8 作者 通讯作者 211: http://dx.doi.org/10.1016/j.phytochem.2023.113681. Liu, Jie, Yan, Qin, Wang, Lixia, He, Xiaoping, Hu, Hong, Liu, Yanchun, Li, Dan, Liu, Yan, Guo, Kai, Li, Shenghong. Secoiridoids from the traditional Chinese medicine Swertia pseudochinensis. Phytochemistry[J]. 2023, 第 10 作者 通讯作者 210: http://dx.doi.org/10.1016/j.phytochem.2023.113642. Guo, Kai, Ren, Xue, Zhou, TingTing, Li, Tao, Liu, YanChun, Tao, Yang, Hu, Hong, Li, Dan, Liu, Yan, Li, ShengHong. Secondary metabolites from the Mongolian medicine Lomatogonium carinthiacum. Fitoterapia[J]. 2023, 第 10 作者 通讯作者 165: http://dx.doi.org/10.1016/j.fitote.2022.105402. Luo, Shihong, Huang, Chunshuai, Hua, Juan, Jing, Shuxi, Teng, Linlin, Tang, Ting, Liu, Yan, Li, Shenghong. Defensive Specialized Metabolites from the Latex of Euphorbia jolkinii. Journal of Chemical Ecology[J]. 2023, 第 8 作者 通讯作者 http://dx.doi.org/10.1007/s10886-023-01413-6. Jing, ShuXi, Fu, Ran, Li, ChunHuan, Hugelshofer, Cedric, Shi, YiMing, Luo, ShiHong, Liu, YanChun, Liu, Yan, Li, ShengHong. Discovery of Unusual Sesterterpenoids from Colquhounia coccinea var. mollis and Their Metabolic Implications. Journal of Natural Products[J]. 2023, 第 9 作者 通讯作者 Ren, Xue, Yuan, Xin, Jiao, ShanShan, He, XiaoPing, Hu, Hong, Kang, JuanJuan, Luo, ShiHong, Liu, Yan, Guo, Kai, Li, ShengHong. Clerodane diterpenoids from the Uygur medicine Salvia deserta with immunosuppressive activity. Phytochemistry[J]. 2023, 第 10 作者 通讯作者 214: http://dx.doi.org/10.1016/j.phytochem.2023.113823. Yuan, Xin, Yan, Qin, Hu, Hong, He, XiaoPing, Wang, LiXia, Liu, YanChun, Liu, Yan, Guo, Kai, Li, ShengHong. Bioactive triterpenoids from the traditional Chinese medicine Swertia mileensis. Phytochemistry Letters[J]. 2023, 第 9 作者 通讯作者 55: 1-5, http://dx.doi.org/10.1016/j.phytol.2023.03.001. Ren, Xue, Yuan, Xin, Chen, YuYing, Zhang, QiaoZhuo, Tan, ChunLin, Kang, JuanJuan, Luo, ShiHong, Liu, Yan, Guo, Kai, Li, ShengHong. New triterpenoids from the aerial parts of the Uygur medicine Salvia deserta. Journal of Asian Natural Products Research[J]. 2023, 第 10 作者 通讯作者 http://dx.doi.org/10.1080/10286020.2023.2289595. Yang, MinJie, Luo, ShiHong, Liu, Yan, Li, ShengHong. Defensive furofuran lignans localized to the oil cells of Neocinnamomum delavayi and their metabolism by a specialist insect. Phytochemistry[J]. 2023, 第 4 作者 通讯作者 215: http://dx.doi.org/10.1016/j.phytochem.2023.113852. Guo, Kai, Zhou, TingTing, Luo, ShiHong, Liu, YanChun, Liu, Yan, Li, ShengHong. Leucosceptrane Sesterterpenoids as a New Type of Natural Immunosuppressive Agents in Treating Sepsis. Journal of Medicinal Chemistry[J]. 2023, 第 6 作者 通讯作者 Liu, Yi, Liu, HongYan, Li, ShengHong, Ma, Wei, Wu, DingTao, Li, HuaBin, Xiao, AiPing, Liu, LiangLiang, Zhu, Fan, Gan, RenYou. Cannabis sativa bioactive compounds and their extraction, separation, purification, and identification technologies: An updated review. Trends in Analytical Chemistry[J]. 2022, 第 3 作者 通讯作者 149: http://dx.doi.org/10.1016/j.trac.2022.116554. Guo, Kai, Luo, ShiHong, Guo, DaLe, Li, DeSen, Hua, Juan, Liu, Yan Chun, Liu, Yan, Li, ShengHong. A monocarbocyclic sesterterpenoid biosynthetic precursor of leucosceptroids from Leucosceptrum canum and its metabolic isomerization by a specialist insect. Organic Chemistry Frontiers[J]. 2022, 第 8 作者 通讯作者 9(8): 2209-2214, http://dx.doi.org/10.1039/d2qo00138a. 李德森, 陈月桂, 郭凯, 凌伊, 刘燕, 黎胜红. 二倍半萜类天然产物的生物合成研究进展. 药学学报[J]. 2022, 第 6 作者 通讯作者 57(4): 931-942, http://lib.cqvip.com/Qikan/Article/Detail?id=7107185016. Zheng, Yu, Liu, ZhiWei, Li, Tao, Li, Xian, Li, ShengHong. KIO3-Mediated gamma-C(sp3)-H Sulfenylation of Enaminones. Organic Letters[J]. 2022, 第 5 作者 通讯作者 24(41): 7533-7537, http://dx.doi.org/10.1021/acs.orglett.2c02824. Guo, Kai, Ren, Xue, Mu, RongFang, Zhou, TingTing, Li, Dan, Hu, Hong, Liu, Yan, Li, ShengHong. Ecdysteroids and spirosterane steroids from the traditional Chinese medicine Paris polyphylla var. yunnanensis. Phytochemistry Letters[J]. 2021, 第 8 作者 通讯作者 45: 117-120, http://dx.doi.org/10.1016/j.phytol.2021.08.008. Zhang, ManWen, Guo, Kai, Zhang, Yu, Teng, LinLin, Huang, QingPu, Liu, Yan, Li, ShengHong. Leucoabietenes A and B, rearranged abietane and ent-abietane diterpene hydrocarbons against resistant infectious fungus and bacterium from the leaves of Leucosceptrum canum. Tetrahedron Letters[J]. 2021, 第 7 作者 通讯作者 81: http://dx.doi.org/10.1016/j.tetlet.2021.153356. Wang, Ying, Liu, YanChun, Li, WenYuan, Guo, Kai, Liu, Yan, Li, ShengHong. Antifeedant, cytotoxic, and anti-inflammatory neo-clerodane diterpenoids in the peltate glandular trichomes and fresh leaves of Ajuga forrestii. Phytochemistry[J]. 2021, 第 6 作者 通讯作者 186: http://dx.doi.org/10.1016/j.phytochem.2021.112731. Hua, Juan, Liu, YanChun, Luo, ShiHong, Liu, Yan, Xiao, ChaoJiang, Li, XiaoNian, Li, ShengHong. Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans. Organic Letters[J]. 2021, 第 7 作者 通讯作者 23(19): 7462-7466, http://dx.doi.org/10.1021/acs.orglett.1c02673. Gao, JianXiong, Chen, YueGui, Li, DeSen, Lin, Liang, Liu, Yan, Li, ShengHong. Cloning and Functional Characterization of a Squalene Synthase from Paris polyphylla var. yunnanensis. Chemistry & Biodiversity[J]. 2021, 第 6 作者 通讯作者 18(7): http://dx.doi.org/10.1002/cbdv.202100342. Jing, ShuXi, Fu, Ran, Li, ChunHuan, Zhou, TingTing, Liu, YanChun, Liu, Yan, Luo, ShiHong, Li, XiaoNian, Zeng, Fang, Li, ShengHong. Immunosuppresive Sesterterpenoids and Norsesterterpenoids from Colquhounia coccinea var. mollis. Journal of Organic Chemistry[J]. 2021, 第 10 作者 通讯作者 86(16): 11169-11176, http://dx.doi.org/10.1021/acs.joc.1c00374. Guo, Kai, Liu, Yan, Li, ShengHong. The untapped potential of plant sesterterpenoids: chemistry, biological activities and biosynthesis. Natural Product Reports[J]. 2021, 第 3 作者 通讯作者 38(12): Teng, LinLin, Mu, RongFang, Liu, YanChun, Xiao, ChaoJiang, Li, DeSen, Gao, JianXiong, Guo, Kai, Li, XiaoNian, Liu, Yan, Zeng, Fang, Li, ShengHong. Immunosuppressive and Adipogenesis Inhibitory Sesterterpenoids with a Macrocyclic Ether System from Eurysolen gracilis. ORGANIC LETTERS[J]. 2021, 第 11 作者 通讯作者 23(6): 2232-2237, https://www.webofscience.com/wos/woscc/full-record/WOS:000631439700052. Guo, Kai, Liu, YanChun, Liu, Yan, Zhang, Han, Li, WenYuan, Shi, QiuMei, Li, XiaoNian, Zeng, Fang, Li, ShengHong. Immunosuppressive gentianellane-type sesterterpenoids from the traditional *** medicine Gentianella turkestanorum. Phytochemistry[J]. 2021, 第 9 作者 通讯作者 187: http://dx.doi.org/10.1016/j.phytochem.2021.112780. Chen, YueGui, Li, DeSen, Ling, Yi, Liu, YanChun, Zuo, ZhiLi, Gan, LiShe, Luo, ShiHong, Hua, Juan, Chen, DingYuan, Xu, Fan, Li, Man, Guo, Kai, Liu, Yan, Gershenzon, Jonathan, Li, ShengHong. A Cryptic Plant Terpene Cyclase Producing Unconventional 18-and 14-Membered Macrocyclic C-25 and C-20 Terpenoids with Immunosuppressive Activity. Angewandte Chemie International Edition[J]. 2021, 第 15 作者 通讯作者 60(48): 25468-25476, http://dx.doi.org/10.1002/anie.202110842. Li, DeSen, Hua, Juan, Luo, ShiHong, Liu, YanChun, Chen, YueGui, Ling, Yi, Guo, Kai, Liu, Yan, Li, ShengHong. An extremely promiscuous terpenoid synthase from the Lamiaceae plant Colquhounia coccinea var. mollis catalyzes the formation of sester-/di-/sesqui-/mono-terpenoids. Plant Communications[J]. 2021, 第 9 作者 通讯作者 2(5): 106-119, http://dx.doi.org/10.1016/j.xplc.2021.100233. Guo, Kai, Zhou, TingTing, Ren, Xue, Li, Dan, Hu, Hong, Liu, YanChun, Liu, Yan, Li, ShengHong. Secoiridoids and triterpenoids from the traditional Tibetan medicine Gentiana veitchiorum and their immunosuppressive activity. Phytochemistry[J]. 2021, 第 8 作者 通讯作者 192: http://dx.doi.org/10.1016/j.phytochem.2021.112961. Geng, Hao, Liu, YanChun, Li, DeSen, Xiao, ChaoJiang, Liu, Yan, Li, XiaoNian, Li, ShengHong. Unusual glycosidic labdane diterpenoids with cytotoxicity from the root of Phlomoides betonicoides. Phytochemistry[J]. 2020, 第 7 作者 通讯作者 173: http://dx.doi.org/10.1016/j.phytochem.2020.112325. Li, WenYuan, Liu, Yan, Lin, YuTian, Liu, YanChun, Guo, Kai, Li, XiaoNian, Luo, ShiHong, Li, ShengHong. Antibacterial harziane diterpenoids from a fungal symbiont Trichoderma atroviride isolated from Colquhounia coccinea var. mollis. Phytochemistry[J]. 2020, 第 8 作者 通讯作者 170: http://dx.doi.org/10.1016/j.phytochem.2019.112198. Liu, Yan, Luo, ShiHong, Hua, Juan, Li, DeSen, Ling, Yi, Luo, Qian, Li, ShengHong. Characterization of defensive cadinenes and a novel sesquiterpene synthase responsible for their biosynthesis from the invasive Eupatorium adenophorum. New Phytologist[J]. 2020, 第 7 作者 通讯作者 https://www.webofscience.com/wos/woscc/full-record/WOS:000579700500001. Guo, Kai, Liu, Xin, Zhou, TingTing, Liu, YanChun, Liu, Yan, Shi, QiuMei, Li, XiaoNian, Li, ShengHong. Gentianelloids A and B: Immunosuppressive 10,11-seco-Gentianellane Sesterterpenoids from the Traditional *** Medicine Gentianella turkestanorum. Journal of Organic Chemistry[J]. 2020, 第 8 作者 通讯作者 85(8): 5511-5515, https://www.webofscience.com/wos/woscc/full-record/WOS:000607535100034. Luo, LiuQiong, Chen, YueGui, Li, DeSen, Liu, Yan, Li, ShengHong. Production of the Inaccessible Sesquiterpene (-)-5-Epieremophilene by Metabolically EngineeredEscherichia coli. Chemistry & Biodiversity[J]. 2020, 第 5 作者 通讯作者 17(7): http://ir.kib.ac.cn/handle/151853/71946, http://www.irgrid.ac.cn/handle/1471x/6927894, http://ir.kib.ac.cn/handle/151853/71947, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000544183300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab. Huang, QingPu, Guo, Kai, Liu, Yan, Liu, YanChun, Li, WenYuan, Geng, Hao, Wang, Ying, Li, ShengHong. Diterpenoids and Flavonoids from the Twigs of Cephalotaxus fortunei var. alpina. Chemistry & Biodiversity[J]. 2020, 第 8 作者 通讯作者 17(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000536998400001. Guo, Kai, Liu, Yan, Luo, ShiHong, Liu, YanChun, Li, DeSen, Li, WenYuan, Li, ShengHong. Detoxification of Plant Aromatic Abietanoids via Cleavage of the Benzene Ring into 11,12-Seco-diterpene Polyenes by a Specialist Insect of Leucosceptrum canum. Organic Letters[J]. 2020, 第 7 作者 通讯作者 22(1): 126-129, http://dx.doi.org/10.1021/acs.orglett.9b04044. Tang, Ting, Li, ChunHuan, Li, DeSen, Jing, ShuXi, Hua, Juan, Luo, ShiHong, Liu, Yan, Li, ShengHong. Peltate glandular trichomes of Colquhounia vestita harbor diterpenoid acids that contribute to plant adaptation to UV radiation and cold stresses. Phytochemistry[J]. 2020, 第 8 作者 通讯作者 172: http://dx.doi.org/10.1016/j.phytochem.2020.112285. Teng, LinLin, Song, TianYang, Chen, YongHong, Chen, YueGui, Zhang, KeQin, Li, ShengHong, Niu, XueMei. Novel Polyketide-Terpenoid Hybrid Metabolites from a Potent Nematicidal Arthrobotrys oligospora Mutant Delta AOL_s00215g278. Journal of Agricultural and Food Chemistry[J]. 2020, 第 6 作者 通讯作者 68(41): 11449-11458, https://www.webofscience.com/wos/woscc/full-record/WOS:000615975700012.