现任中国科学院化学研究所研究员、博士生导师，中国科学院分子识别与功能重点实验室主任。1989年毕业于湘潭大学化学系，1992年在中国科学院化学研究所获得硕士学位，1998在香港理工大学应用生物与化学科技系获得博士学位，导师为陈新滋院士。1992-1995年任中国科学院化学研究所实习研究员和助理研究员，1998年通过中国科学院化学研究所优秀人才招聘计划回所工作，任副研究、课题组长，2003年聘任为中国科学院化学研究所研究员。2003年获国家杰出青年科学基金资助，2009年获国务院政府特殊津贴。目前主要研究领域为不对称催化和树状大分子的设计合成及功能应用。共发表研究论文140余篇，其中Chem. Rev.1篇, Angew. Chem. Int. Ed.5篇, J. Am. Chem. Soc.3篇，H-因子为30；撰写和主编专著3部；应邀参加国内外学术会议并作邀请报告40余次。部分成果作为第二完成人获2005年国家自然科学二等奖。

不对称催化 环境友好的催化反应 功能树状分子的设计合成及组装 生物活性杂环化合物的合成

Chenghao Li,‡ Shuxin Zhang,‡ Shan Li, Yu Feng * and Qing-Hua Fan,* "Ruthenium-catalyzed enantioselective hydrogenation of quinoxalinones and quinazolinones", Org. Chem. Front. 2022, 9, 400–406. Shu-Xin Zhang, Cong Xu, Niannian Yi, Shan Li, Yan-Mei He, Yu Feng,* and Qing-Hua Fan,* "Ruthenium-Catalyzed Enantioselective Hydrogenation of 9-Phenanthrols", Angew. Chem. Int. Ed. 2022, 61, e202205739. Faju Li, Linhong Long, Yan-Mei He, Zeyu Li, Hui Chen,* and Qing-Hua Fan,* "Manganese-Catalyzed Asymmetric Formal Hydroamination of Allylic Alcohols: A Remarkable Macrocyclic Ligand Effect", Angew. Chem. Int. Ed. 2022, 61, e202202972. Yu-Ping Tang, Yi-Er Luo, Jun-Feng Xiang, Yan-Mei He,* and Qing-Hua Fan,* "Rhodium-Catalyzed ON-OFF Switchable Hydrogenation Using a Molecular Shuttle Based on a [2]Rotaxane with a Phosphine Ligand", Angew. Chem. Int. Ed. 2022, 61, e202200638. Yier Luo, Guanghui Ouyang, Yuping Tang, Yan-Mei He,* and Qing-Hua Fan,* "Diaza-Crown Ether-Bridged Chiral Diphosphoramidite Ligands: Synthesis and Applications in Asymmetric Catalysis", J. Org. Chem. 2020, 85, 8176−8184. Chenghao Li,§ Yixiao Pan,§ Yu Feng,* Yan-Mei He, Youran Liu, and Qing-Hua Fan,* "Asymmetric Ruthenium-Catalyzed Hydrogenation of Terpyridine Type N‑Heteroarenes: Direct Access to Chiral Tridentate Nitrogen Ligands", Org. Lett. 2020, 22, 6452−6457. Li-Ren Wang, Dan Chang, Yu Feng,* Yan-Mei He, Guo-Jun Deng,* and Qing-Hua Fan*, "Highly Enantioselective Ruthenium-Catalyzed Cascade Double Reduction Strategy: Construction of Structurally Diverse Julolidines and Their Analogues", Org. Lett. 2020, 22, 2251−2255. Shanshan Zhang, Fei Chen,* Yan-Mei He, and Qing-Hua Fan,* "Asymmetric Hydrogenation of Dibenzo[c,e]azepine Derivatives with Chiral Cationic Ruthenium Diamine Catalysts", Org. Lett. 2019, 21, 5538−5541. Ya Chen, Yixiao Pan, Yan-Mei He,* and Qing-Hua Fan,* "Consecutive Intermolecular Reductive Amination/Asymmetric Hydrogenation: Facile Access to Sterically Tunable Chiral Vicinal Diamines and N-Heterocyclic Carbenes", Angew. Chem. Int. Ed. 2019, 58, 16831–16834. Youran Liu, Fei Chen, Yan-Mei He, Chenghao Li, and Qing-Hua Fan,* "Enantioselective synthesis of tunable chiral pyridine–aminophosphine ligands and their applications in asymmetric hydrogenation", Org. Biomol. Chem. 2019, 17, 5099–5105. Cong Xu, Yu Feng, Faju Li, Jiahong Han, Yan-Mei He, and Qing-Hua Fan,* "A Synthetic Route to Chiral Benzo-Fused N‑Heterocycles via Sequential Intramolecular Hydroamination and Asymmetric Hydrogenation of Anilino-Alkynes", Organometallic DOI: 10.1021/acs.organomet.9b00183. Ya Chen, Yan-Mei He, Shanshan Zhang, Tingting Miao, and Qing-Hua Fan,* "Rapid Construction of Structurally Diverse Quinolizidines, Indolizidines, and Their Analogues via Ruthenium-Catalyzed Asymmetric Cascade Hydrogenation/Reductive Amination", Angew. Chem. Int. Ed. 2019, 58, 3809 –3813. Bin Li, Cong Xu, Yan-Mei He, Guo-Jun Deng, and Qing-Hua Fan,* "Asymmetric Hydrogenation of Bis(quinolin-2-yl)methanes: A Direct Access to Chiral 1,3-Diamines", Chin. J. Chem. 2018, 36, 1169-1173. Yuping Tang, Yanmei He, Yu Feng, and Qing-Hua Fan,* "Asymmetric Supramolecular Catalysis Based on Macrocyclic Host Molecules", Progress in Chemistry 2018, 30, 476-490. Tingting Miao, Zi-You Tian, Yan-Mei He, Fei Chen, Ya Chen, Zhi-Xiang Yu,* and Qing-Hua Fan,* "Asymmetric Hydrogenation of In Situ Generated Isochromenylium Intermediates by Copper/Ruthenium Tandem Catalysis", Angew. Chem. Int. Ed. 2017, 56, 4135–4139. Zhusheng Yang, Ziyuan Ding, Fei Chen,* Yan-Mei He, Nianfa Yang,* and Qing-Hua Fan,* "Asymmetric Hydrogenation of Cyclic Imines of Benzoazepines and Benzodiazepines with Chiral, Cationic Ruthenium–Diamine Catalysts", Eur. J. Org. Chem. 2017, 1973–1977. Zhusheng Yang, Fei Chen,* Shuxin Zhang, Yanmei He, Nianfa Yang,* and Qing-Hua Fan,* "Ruthenium-Catalyzed Enantioselective Hydrogenation of Phenanthridine Derivatives", Org. Lett. 2017, 19, 1458−1461. Tianli Wang, Ya Chen, Guanghui Ouyang, Yan-Mei He,* ZhiyanLi and Qing-Hua Fan,* "Solvent-Regulated Asymmetric Hydrogenation of Quinoline Derivatives in Oligo(Ethylene Glycol)s through Host–Guest Interactions", Chem.Asian J. 2016, 11, 2773–2777. Zhusheng Yang, Fei Chen,* Yanmei He, Nianfa Yang and Qing-Hua Fan,* "Highly Enantioselective Synthesis of Indolines: Asymmetric Hydrogenation at Ambient Temperature and Pressure with Cationic Ruthenium Diamine Catalysts", Angew. Chem. Int. Ed. 2016, 55,13863–13866. Wenpeng Ma, Jianwei Zhang, Cong Xu, Fei Chen, Yan-Mei He and Qing-Hua Fan,* "Highly Enantioselective Direct Synthesis of Endocyclic Vicinal Diamines through Chiral Ru(diamine)-Catalyzed Hydrogenation of 2,2'-Bisquinoline Derivatives" Angew. Chem. Int. Ed. 2016, 55, 2891-12894. Wenpeng Ma, Fei Chen, Youran Liu, Yan-Mei He, and Qing-Hua Fan,* "Ruthenium-Catalyzed Enantioselective Hydrogenation of 1,8-Naphthyridine Derivatives" Org. Lett. 2016, 18, 2730–2733. Huan-Li Sun, Fei Chen, Ming-Sheng Xie, Hai-Ming Guo,* Gui-Rong Qu, Yan-Mei He, and Qing-Hua Fan,* "Asymmetric Hydrogenation of α-Purine Nucleobase-Substituted Acrylates with Rhodium Diphosphine Complexes: Access to Tenofovir Analogues", Org. Lett. 2016, 18, 2260–2263. Yi Peng, Yu Feng,* Guo-Jun Deng, Yan-Mei He, and Qing-Hua Fan "From Weakness to Strength: C–H/π-Interaction-Guided Self-Assembly and Gelation of Poly(benzyl ether) Dendrimers", Langmuir 2016, 32, 9313–9320. Yu Feng,* Hui Chen, Zhi-Xiong Liu, Yan-Mei He and Qing-Hua Fan, "A Pronounced Halogen Effect on the Organogelation Properties of Peripherally Halogen Functionalized Poly(benzyl ether) Dendrons", Chem. Eur. J. 2016, 22, 4980-4990. Zhi-Xiong Liu, Yihua Sun, Yu Feng,* Hui Chen, Yan-Mei He and Qing-Hua Fan, "Halogen-bonding for visual chloride ion sensing: a case study using supramolecular poly(aryl ether) dendritic organogel systems", Chem. Commun. 2016, 52, 2269-2272.