2007/9—2011/7 安徽大学生命科学学院 生物工程 工学学士

2011/9—2016/7 中国科学院广州生物医药与健康研究院 发育生物学 理学博士

2016/7—2017/12 中国科学院广州生物医药与健康研究院 助理研究员

2018/1—至今 中国科学院广州生物医药与健康研究院 副研究员

基因修饰大动物的建立； 利用大动物模型进行干细胞或基因治疗研究。

1. Kepin Wang#, Qin Jin#, Degong Ruan#, Yi Yang, Qishuai Liu, Han Wu, Zhiwei Zhou, Zhen Ouyang, Zhaoming Liu, Yu Zhao, Bentian Zhao, Quanjun Zhang, Jiangyun Peng, Chengdan Lai, Nana Fan, Yanhui Liang, Ting Lan, Nan Li, Xiaoshan Wang, Xinlu Wang, Yong Fan, Pieter A. Doevendans, Joost P.G. Sluijter, Pentao Liu, Xiaoping Li*, and Liangxue Lai*, Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing. Genome Research 2017, 27(12): 2061-2071 (#co-First authors). 2. Yi Yang#, Kepin Wang#, Han Wu, Qin Jin, Degong Ruan, Zhen Ouyang, Bentian Zhao, Zhaoming Liu, Yu Zhao, Quanjun Zhang, Nana Fan, Qishuai Liu, Shimei Guo, Lei Bu, Yong Fan, Xiaofang Sun, Xiaoping Li*, Liangxue Lai*, Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering. Journal of Molecular Cell Biology 2016, 8(2): 174-177 (#co-First authors.

3. Degong Ruan#, Jiangyun Peng#, Xiaoshan Wang#, Zhen Ouyang#, Yi Yang, Fangbing Chen, Weikai Ge, Han Wu, Zhaoming Liu, Yu Zhao, Bentian Zhao, Quanjun Zhang, Chengdan Lai, Nana Fan, Zhiwei Zhou, Qishuai Liu, Nan Li, Qin Jin, Hui Shi, Jingke Xie, Xiaoyu Yang, Hong Song, Kepin Wang*, Xiaoping Li*, Liangxue Lai*, Xist derepression in active X chromosome hinders pig somatic cell nuclear transfer. Stem Cell Reports 2018, 10(2): 494-508 (*Corresponding author)

4. Zou Qingjian, Yan Quanmei, Zhong Juan, Wang Kepin, Sun Haitao, Yi Xiaoling, Lai Liangxue, Direct conversion of human fibroblasts into neuronal restricted progenitors. The Journal of biological chemistry 2014, 289(8): 5250-5260

5. Kai Han#, Liuping Liang#, Li Li#, Zhen Ouyang, Bentian Zhao, Qi Wang, Zhaoming Liu, Yu Zhao, Xiaoshuai Ren, Fei Jiang, Chengdan Lai, Kepin Wang, Sen Yan, Liang Huang, Lin Guo, Kang Zeng*, Liangxue Lai*, Nana Fan*. Generation of Hoxc13 knockout pigs recapitulates human ectodermal dysplasia-9. Human Molecular Genetics 2017, 26: 184-191