教育背景

08/1998-07/2001 哲学/医学博士

专业：细胞和分子生物学， 北京大学医学部（原北京医科大学）

导师：钟南山

中国工程院院士,

09/1995-07/1998 内科学硕士

导师： 何权赢教授，北京大学附属人民医院呼吸科

09/1986-07/1991 山东医科大学医学系学士

专业背景

08/2012- 高级研究员，香雪制药公司 大分子项目

07/2008- 07/2012 研究科学家，基因治疗中心，美国国立儿童医院研究所 / 综合癌症中心

01/2006 -06/2008 研究科学家, 美国俄亥俄州立大学医学中心，戴维斯心肺研究所

05/2004-12/2005 博士后研究员, 美国俄亥俄州立大学医学中心, 戴维斯心肺研究所

11/2001-04/2004 博士后研究员，美国弗罗里达大学医学院

导师：Edward R. Block 大学杰出教授， 医学系主任

10/1991-08/1995 医师，山东省立医院内科

广州呼吸病研究所所长，

呼吸疾病国家重点实验室主任，

中华医学会前会长，

世界卫生组织医学顾问

1. Peng Z, Weber C, Han Z, Scott JR, Chan M, Lin HJ. Dichotomy effects of Akt signaling in

breast cancer. Mol cancer. 2012 Aug 24;11(1):61. Epub ahead of print

2. Han Z, L Druhan, A Cardounel, L Chicoine. Regulation of endothelial nitric oxide production by

protein methyltransferase's. FASEB J. 2011(published) note: conference article

3. Natale E, Han Z, Slutzky JL, Chicoine LG. Resveratrol reverses both thromboxane A2 receptor and

non receptor (K+) mediated pulmonary vasoconstriction. FASEB J 2009 (published) note:

conference article

4. Han Z, Pope AJ, Chicoine LG & Cardounel AJ. Increased ADMA/protein methylation modulates nitric

oxide generation in hypoxic human lung microvascular endothelial cells. FASEB J 2009 (published)

note: conference article

5. Han Z, Varadharaj S., Jones C.I., Zweier JL, Alevriadou BR. Mitochondria-derived reactive oxygen

species mediate heme oxygenase-1 expression in sheared endothelial cells. J Pharmacol Exp Ther. 2009

Apr;329(1):94-101. Epub 2 009 Jan 8.

6. Han Z*, Jones C.I*. Alevriadou BR and Zweier JL Endothelial cell respiration is affected by the

oxygen tension during shear exposure: role of mitochondria peroxynitrite. Am. J. Physiol. (cell

physiology), 2008 Jul; 295(1):C180-91. * contribute equally

Email: hanzhaosheng@gmail.com; hanzhsh@xphcn.com

Phone: (020)-22211900(o); 18988918152 (c)

7. Han, Z, Chen YR, Jones CI, Meenakshisundaram G, Zweier JL., Alevriadou BR Shear-induced

reactive nitrogen species inhibit mitochondrial respiratory complex activities in cultured vascular

endothelial cells. Am. J. Physiol. (cell physiology). 2007 Mar; 292(3): C1103-12

8. Jones CI, Zhu H, Han Z, Li Y, Alevriadou BR. Regulation of antioxidants and phase 2 enzymes by

shear-induced reactive oxygen species in endothelial cells. Ann. Biomed Eng. 2007 May; 35(5)683-93.

9. Han Z*, Cui Z*, Li Z, Hu H, Patel J.M., Antony V., Block E.R., Su Y. Involvement of calpaincalpastatin

in cigarette smoke-induced inhibition of lung endothelial NOS. Am. J. Respir Cell Mol

Biol. 2005 Nov; 33(5):513-20, * contribute equally

10. Han Z, Su Y, Block ER. Involvement of acetylated histone 3 in cigarette extract-induced inhibition

of nitric oxide synthase gene transcription in pulmonary artery endotelial cells. Am J of Respir and

Crit Care Med. 2004Apr; 169(7):A395

11. Xu Y, Wen S, Han Z, Zhong NS. The role of endotelial -1 in initial phase of airway inflammation.

Am J of Respir and Crit Care Med. 2002 Apr; 165(8):A731

12. Su Y, Cao, W, Han Z, Block ER. Cigarette smoke extract inhibits angiogenesis of pulmonary artery

endothelial cells: The role of calpain. Am J Physiol Lung Cell Mol Physiol 2004 Oct;287(4):L794-800

13. Han Z, Xu J, and Zhong NS. The expression of matrix metalloproteinase-9 within the airways in

asthma. Respiratory Medicine 2003; 97:563-567

14. Han Z, Xu J, and Zhong NS. TNF, Con A and mechanical Injury stimulate matrix metalloproteinase-

9 expression in human bronchial endothelial cell. Chinese Journal of Pathophysiology. 2002;

18(7):741-744 (in Chinese)

15. Han, Z, Xu J, and Zhong NS. The expression of matrix metalloproteinase- 9 and the effect of

interleukin-10 gene transfer in Balb/c mice infected by respiratory syncytial virus. Chinese Journal of

Pathophysiology. (accepted for publication), 2002 (in Chinese)

16. Han Z, Xu J, and Zhong NS. Clinical study of Matrix Metallopreoteinase-9 by airway biopsy from

asthmatic subjects. Chinese Journal of Practical Internal Medicine 2002;22 (6): 331-3 (in Chinese)

17. Han Z, Xu J., and Zhong NS. The Matrix Metalloproteinases-9 expression from lung tissue in OVA

sensitized guinea pigs and the effect of antisense endothelin converting enzyme gene transfer. Chinese

Journal of Tuberculosis and Respiratory Medicine 2001; 45(11):702-703 (in Chinese)

18. Han Z, He Q. Quantitative analysis for emphysemous area using High resolution CT and its

relationship to interlukin-8 plasma in subjects with emphysema. Chinese Journal of Practical Internal

Medicine 2001; 47 (9): 546-547. (in Chinese)

19. Han Z, He Q. The increased expression of matrix metalloproteinase in BALF of emphysema.

Foreign Medicine Science-Branch of Internal Medicine 1999;17(5):122- 123 (in Chinese)

20. Han Z, Xu J., and Zhong NS. The expression of Matrix Metalloproteinases-9 in human airway

epithelial cell. Chinese Journal of Tuberculosis and Respiratory Medicine 2000;23(12):747-49

21. Han Z, Xu J, Zhong NS. Matrix Metalloproteases and respiratory diseases. Foreign Medicine Science

–Branch of Internal Medicine. 2000; 20(5):192-196 (in Chinese)

22. Han Z, He Q. The advancement of Chronic Obstructive Pulmonary Disease (COPD) pathogenesis.

Foreign Medicine Science -Branch of Respiratory Medicine supplement. 1998; 17(2)533-35 (in

Chinese)