青琳森，男，1981年9月生，四川南充人，执业药师，中国科学院成都生物研究所副研究员、硕士生导师。

教育经历：

1999.09-2003.06华西医科大学，药学院，药学专业本科

2003.09-2006.06四川大学，华西药学院，生药学专业硕士

其间：2004.06-2005.05香港浸会大学，中医药学院，访问学者

2008.09-2011.06中国科学院成都生物研究所，药物化学专业博士

工作经历：

2006.07-2008.08成都地奥制药集团，药物研究所，助理工程师

2011.07-2013.06中国科学院成都生物研究所，博士后

其间：2012.08-2012.11美国杰克逊州立大学，化学系，研究助理

2013.7至今中国科学院成都生物研究所，副研究员承担科研项目情况 [1]四川省科技厅重点研发项目，《黄芪甲苷水溶性衍生物的成药性研究》，2019.1-2020.12

[2]中国科学院“西部青年学者”（院内A类）项目，2019.1-2021.12

[3]中国科学院战略生物资源服务网络计划“活性天然化合物发现、评价与转化平台”项目，《基于多靶标的微循环改善创新药物LS-102的临床前药效学研究》，2018.8-2021.7

[4]中国博士后科学基金第6批特别资助，《基于磁性纳米配体垂钓的降糖中药“谱——效”相关指纹图谱》，2013.6-2016.6

[5]中国科学院“西部博士”人才培养计划，2013.1-2016.6

[6]国家自然科学基金青年基金，《基于磁性纳米配体垂钓技术的降糖中药活性代谢产物研究》，2013.1-2015.12

[7]中国博士后科学基金第50批面上资助，《用磁性纳米配体垂钓技术筛寻中药肝代谢物中降糖活性成份》，2011.9-2013.12

作为项目主要研究人员，参与包括科技部国际合作计划，国家自然科学基金面上项目、香港特区政府卫生署项目、澳门科学技术发展基金等多项课题的研究。

研究方向 天然活性成分分析与新药研发

社会任职及荣誉（含获奖） 中国科学院院长优秀奖

四川省优秀大学毕业生

卢嘉锡优秀研究生奖

中国化学会第十六届有机分析与生物分析学术研讨会口头报告优秀奖

发表论文（SCI一作/通讯）：

[1]SunWen-Xia,ZhangZhi-Feng,XieJing,HeYing,ChengYong,DingLi-Sheng,LuoPei*,QingLin-Sen*.DeterminationofaastragalosideIVderivativeLS-102inplasmabyultra-performanceliquidchromatography-tandemmassspectrometryindogplasmaanditsapplicationinapharmacokineticstudy.Phytomedicine,2019,53:243-251.

[2]XueYing,XieJing,XuXian-Shun,YongLi,HuBin,LiangJian,LiXing-De,QingLin-Sen*.UPLC-QqQ/MScombinedwithsimilarityassessmentof17nucleicacidconstituentsin147ediblefungifromSichuanBasin,China.FoodResearchInternational,2019,120:577-585.

[3]QingLin-Sen,ChenTing-Bo,SunWen-Xia,ChenLi,LuoPei,ZhangZhi-Feng,DingLi-Sheng.Pharmacokineticscomparison,intestinalabsorptionandacutetoxicityassessmentofanovelwater-solubleastragalosideIVderivative(astragalosidicacid,LS-102).EuropeanJournalofDrugMetabolismandPharmacokinetics,2019,44(2):251-259.

[4]XueYing,JinWei,XuXian-Shun,YongLi,HuBin,XiongJing,HuXue-Mei,QingLin-Sen*,XieJing*.QualityevaluationofTricholomamatsutakebasedonthenucleicacidcompoundsbyUPLC-TOF/MSandUPLC-QqQ/MS.Molecules,2019,24(1):34.

[5]XueYing#,QingLin-Sen#,YongLi,XuXian-Shun,HuBin,TangMing-Qing,XieJing.DeterminationofflavonoidglycosidesbyUPLC-MStoauthenticatecommerciallemonade.Molecules,2019,24(16):3016.

[6]WangQian-Long,XieJing,LiangJian,DongGeng-Ting,DingLi-Sheng,LuoPei*,QingLin-Sen*.Competitiveproteinbindingassayofnaproxenbyhumanserumalbuminfunctionalizedsilicondioxidenanoparticles.Molecules,2019,24(14):2593.

[7]XieJing,XiongJing,DingLi-Sheng,ChenLi,ZhouHua,LiuLiang,ZhangZhi-Feng,HuXue-Mei,LuoPei*,QingLin-Sen*.AefficientmethodtoidentifycardioprotectivecomponentsofAstragaliRadixusingacombinationofmolecularlyimprintedpolymers-basedknockoutextractandactivityevaluation.JournalofChromatographyA,2018,1576:10-18.

[8]ChenChu,XueYing,LiQing-Miao,WuYan,LiangJian,QingLin-Sen*.Neutrallossscan-basedstrategyforintegratedidentificationofamorfrutinderivatives,newperoxisomeproliferator-activatedreceptorgammaagonists,fromAmorphaFruticosabyUPLC-QqQ-MS/MSandUPLC-Q-TOF-MS.JournalofTheAmericanSocietyforMassSpectrometry,2018,29(4):685-693.

[9]XueYing,XuXian-Shun,YongLi,HuBin,LiXing-De,ZhongShi-Hong,LiYi,XieJing*,QingLin-Sen*.Optimizationofvortex-assisteddispersiveliquid-liquidmicroextractionforthesimultaneousquantitationofelevennon-anthocyaninpolyphenolsincommercialblueberryusingthemulti-objectiveresponsesurfacemethodologyanddesirabilityfunctionapproach.Molecules,2018,23(11):2921.

[10]QingLin-Sen,PengShu-Lin,LiangJian,DingLi-Sheng.Astragalosidicacid:anewwater-solublederivativeofastragalosideIVpreparedusingremarkablysimpleTEMPO-mediatedoxidation.Molecules,2017,22(8):1275.

[11]WangQian-Long,LiJie,LiXing-De,TaoWan-Jun,DingLi-Sheng,LuoPei*,QingLin-Sen*.Anefficientdirectcompetitivenano-ELISAforresidualBSAdeterminationinvaccines.AnalyticalandBioanalyticalChemistry,2017,409(19):4607-4614.

[12]WangQian-Long,XieJing,LiXing-De,DingLi-Sheng,LiangJian,LuoPei*,QingLin-Sen*.Developmentofanano-SiO2basedenzyme-linkedligandbindingassayforthedeterminationofibuprofeninhumanurine.Talanta,2017,167:617-622.

[13]WangQian-Long,LiJie,LiXing-De,DingLi-Sheng,XieJing*,QingLin-Sen*.Asimplenano-SiO2basedELISAmethodforresiduedetectionof2,4-dichlorophenoxyaceticacidinbeansprouts.FoodAnalyticalMethods,2017,10(5):1500-1506.

[14]XieJing,LiJie,LiangJian,LuoPei*,QingLin-Sen*,DingLi-Sheng.Determinationofcontentsofcatechinsinoolongteasbyquantitativeanalysisofmulti-componentsviaasinglemarker(QAMS)method.FoodAnalyticalMethods,2017,10(2):363-368.

[15]QingLin-Sen,XueYing,DingLi-Sheng,LiuYi-Ming,LiangJianLiao,XunArapidstudyofbotanicaldrug-druginteractionwithproteinbyre-ligandfishingusinghumanserumalbumin-functionalizedmagneticnanoparticles.NaturalProductCommunications.2015,10(12):2161-2163.

[16]XieJing,LiaoXun,QingFang-Zhu,LuoPei,ZhangZhi-Feng,HuangJing*,QingLin-Sen*.Anovelrhein-functionalizedresinwithapplicationforthepreconcentrationofanthraquinones.AnalyticalLetters.2014,47(14):2332-2340.

[17]QingLin-Sen,XueYing,LiuYi-Ming,LiangJian,XieJing,LiaoXun.Rapidmagneticsolid-phaseextractionfortheselectivedeterminationofisoflavonesinsoymilkusingbaicalin-functionalizedmagneticnanoparticles.JournalofAgriculturalandFoodChemistry,2013,61(34),8072-8078.

[18]QingLin-Sen,XueYing,ZhangJian-Guang,ZhangZhi-Feng,LiangJian,JiangYan,LiuYi-Ming,LiaoXun.IdentificationofflavonoidglycosidesinRosachinensisflowersbyliquidchromatography–tandemmassspectrometryincombinationwith13Cnuclearmagneticresonance.JournalofChromatographyA,2012,1249,130-137.

[19]QingLin-Sen,TangNan,XueYing,LiangJian,LiuYi-Ming,LiaoXun.Identificationofenzymeinhibitorsusingtherapeutictargetprotein-magneticnanoparticleconjugates.AnalyticalMethods,2012,4(6),1612-1615.

[20]QingLin-Sen,XiongJing,XueYing,LiuYi-Ming,GuangBin,DingLi-Sheng,LiaoXun.Usingbaicalin-functionalizedmagneticnanoparticlesforselectivelyextractingflavonoidsfromRosachinensis.JournalofSeparationScience,2011,34(22),3240-3245.

[21]QingLin-Sen,XueYing,DengWen-Long,LiaoXun,XuXue-Min,LiBo-Gang,LiuYi-Ming.Ligandfishingwithfunctionalizedmagneticnanoparticlescoupledwithmassspectrometryforherbalmedicineanalysis.AnalyticalandBioanalyticalChemistry,2011,399(3),1223-1231.

[22]QingLin-Sen#,ShanXiao-Qing#,XuXue-Min,XueYing,DengWen-Long,LiBo-Gang,WangXiao-Ling,LiaoXun.RapidprobeandisolationofbioactivecompoundsfromDioscoreapanthaicausinghumanserumalbuminfunctionalizedmagneticnano-particles(HSA-MNPs)-basedligandfishingcoupledwithelectrosprayionizationmassspectrometry.RapidCommunicationsinMassSpectrometry,2010,24(22),3335-3339.

[23]QingLin-Sen,XueYing,ZhengYi,XiongJing,LiaoXun,DingLi-Sheng,LiBo-Gang,LiuYi-Ming.LigandfishingfromDioscoreanipponicaextractusinghumanserumalbuminfunctionalizedmagneticnanoparticles.JournalofChromatographyA,2010,1217(28),4663-4668.

授权专利：

[1]青琳森，丁立生，彭树林，李帮经，梁健．一种黄芪甲苷衍生物及其制备方法和应用，专利号ZL201611166597.2(20180814)

[2]青琳森，杨雪锋，丁立生，梁健，饶亮明，李兴德，蒋立银，帅克．一种伏立康唑的合成方法，专利号ZL201610984653.7(20190222)

[3]青琳森，王乾龙，杨雪锋，丁立生．山菅兰的活性提取物及其制备方法和应用，专利号ZL201610187409.8(20190104)

[4]青琳森，王乾龙，丁立生，梁健，饶亮明，李兴德，蒋立银，帅克．一种牛血清白蛋白检测探针及其制备方法和应用，专利号ZL201610986773.0(20180622)

[5]青琳森，廖循，薛莹，熊静，彭树林，丁立生．一种表面键合黄芩苷磁性纳米粒子及其制备方法和用途，专利号ZL201010545352.7(20130904)