个人简介
朱书教授,博导,2017年加入免疫所。科技部重点研发青年项目首席科学家,基金委优青、MIT 35 Innovators under 35、求是杰出青年学者奖获得者。2006年毕业于中国科大,获郭沫若奖;2012年毕业于上海生命科学研究院,获吴瑞奖;2012至2017年于耶鲁大学免疫系从事博士后研究,获Helen Hay Fellowship。在Nature、Science、Nat Immunol、Nat Med等发表论文40余篇,引用3000余次。
研究领域
向肠道微生物及其诱导的免疫反应实现对人类感染、炎症、代谢、肿瘤等疾病的干预。
近期论文
1. Ma H*, Hu T*, Tao W, Tong J, Han Z, Herndler-Brandstetter D, Wei Z, Liu Z, Li M, Xu X, Zhang K, Liu R, Cho H J, Li H#, Huang H#, Flavell R#, Zhu S#.A lincRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis.Cell research. 2023.Accepted. 2. Ren X*, Wang D*, Zhang G*, Zhou T, Wei Z, Yang Y, Zheng Y, Lei X, Tao W, Wang A, Li M#, Flavell RA#, Zhu S#. Nucleic DHX9 cooperates with STAT1 to transcribe interferon-stimulated genes.Science advances. 2023 Feb 3;9(5):eadd5005. (IF=15) 3. Chen C*, Zhang W*, Zhou T, Liu Q, Han C, Huang Z, Chen S, Mei Q, Zhang C, Zhang K, Ma H, Zhou R, Jiang W#, Pan W, Zhu S#. Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation. Cell reports. 2022 Nov 29;41(9):111741. (IF=10) 4. Zhang G*, Wang Q*, Tao W*, Jiang W, Elinav E, Wang Y#, Zhu S#. Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis. Nature Biomedical Engineering. s41551-022-00903-4. (IF=29.2) 5. Wang A, Tao W, Tong J, Gao J, Wang J, Hou G, Qian C, Zhang G, Li R, Wang D, Ren X, Zhang K, Ding S, Flavell R, Li H, Pan W#, Zhu S#.m6A modifications regulate intestinal immunity and rotavirus infection. Elife. 2022;11:e73628 DOI: https://doi.org/10.7554/eLife.73628 (IF=8.1) 6. Shen C*, Li R*, Negro R, Cheng J, Vora SM, Fu TM, Wang A, He K, Andreeva L, Gao P, Tian Z, Flavell RA, Zhu S#, Wu H#.Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome. Cell. 2021 Oct 14:S0092-8674(21)01115-6. doi:10.1016/j.cell.2021.09.032.(IF=41.6) 7. Wang Y*, He Y*, Sheng B*, Lei X, Tao W, Zhu X, Wei Z, Fu R, Wang A, Bai S, Z Zhang Z, N Hong N, C Ye C, Y Tian Y, Wang J, Zhang K, Yang H, Li L#, Li H#, Flavell R#, Zhu S#.The RNA helicase Dhx15 mediates Wnt-induced anti-microbial protein expression in Paneth cells.PNAS. 10.1073/pnas.2017432118 (IF=11.2) 8. Guo M*, Tao W*, Flavell R#, Zhu S#. Potential intestinal infection and fecal–oral transmission of SARS-CoV-2.Nature Reviews Gastroenterology & Hepatology. 10.1038/s41575-021-00416-6 (IF=46.8) 9. Tao W*, Zhang G*, Wang X*, Ma X, Jin T, Liu L #, Weng J#, Zhu S#. Analysis of the intestinal microbiota in COVID19 patients and its correlation with the inflammatory factor IL-18 and SARS-CoV-2-specific IgA. Medicine in Microecology. 10.1016/j.medmic.2020.100023 10. Wang Y*, He K*, Sheng B*, Lei X, Tao W, Zhu X, Wei Z, Fu R, Wang A, Bai S, Zhang Z, Hong N, Ye C, Tian Y, Wang J, Zhang K, Yang H, Li L#, Li H#, Flavell R#, Zhu S#. The RNA helicase Dhx15 mediates Wnt-induced anti-microbial protein expression in Paneth cells.PNAS. 10.1073/pnas.2017432118 (IF=11.2) 11. Zhang Z*, Zhang G*, Guo M*, Tao W*, Liu X, Wei H, Jin T#, Zhang Y#, Zhu S#. Potential intestinal infection and fecal–oral transmission of SARS-CoV-2. Pathogens. 2021, 10(7), 881. doi: 10.3390/pathogens10070881(IF=3.5) 12. Tong J, Wang X, Liu Y, Ren X, Wang A, Chen Z, Yao J, Mao K, Liu T, Meng F, Pan W, Zou Q, Liu J, Zhou Y, Xia Q#, Flavell R#, Zhu S#, Li H#. Pooled CRISPR Screening Identifies m6A as a Positive Regulator of Macrophage Activation. Science Advance. 10.1126/sciadv.abd4742 (IF=14.1) 13. Chen Y, Zhao S, Hu J, Han C, Lv X, Wang G, Wang S, Bo P, Zhang J, Wu W, Gui W, Tang Q#, Liu Q#, Zhu S#, Yu F#. Increased Accumulation of ‐Synuclein in Inflamed Appendices of Parkinson s Disease. Movement Disorders. 2021 Apr 20. doi: 10.1002/mds.28553 (IF=10.3) 14. Zheng X, Liu L, Meng G, Zhu S, Zhou R#, Jiang W#. IL-18 maintains the homeostasis of mucosal immune system via inflammasome-independent but microbiota-dependent manner. Science Bulletin. Doi: 10.1016/j.scib.2021.01.025 (IF=11.8) 15. Song H, Song J, Cheng M, Zheng M, Wang T, Tian S, Flavell RA, Zhu S, Li HB, Ding C, Wei H, Sun R, Peng H, Tian Z. METTL3-mediated m6A RNA methylation promotes the anti-tumor immunity of natural killer cells.Nat Commun. 2021 Sep 17;12(1):5522. doi: 10.1038/s41467-021-25803-0. (IF=14.9) 16. Xu G, Liu C, Zhou S, Li Q, Feng Y, Sun P, Feng H, Gao Y, Zhu J, Luo X, Zhan Q, Liu S, Zhu S, Deng H, Li D, Gao P. Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion. Molecular Cell. doi.org/10.1016/j.molcel.2021.05.002 (IF=18.0) 17. Han H, Cao Y, Feng C, Zheng Y, Zhu S, Shang C, Yuan C, Zong G. Association of a Healthy Lifestyle with All-Cause and Cause-Specific Mortality Among Individuals with Type 2 Diabetes: A Prospective Study in UK Biobank Short Running. Diabetes Care. doi.org/10.2337/dc21-1512 (IF=19.1)