张璇 照片

张璇

副研究员

所属大学: 中国科学技术大学

所属学院: 生命科学学院

邮箱:
xuanzbin@ustc.edu.cn

个人主页:
https://faculty.ustc.edu.cn/Zhang_Xuan/zh_CN/index.htm

个人简介

博士,副教授。2005年毕业于安徽大学,获理学学士。同年进入中国科学技术大学微尺度国家实验室硕博连读,于2010年获得理学博士学位,2011年至2015年在美国Cornell大学生物化学系从事博士后研究工作。2015年4月起加入中国科学技术大学生命科学学院臧建业教授课题组(http://zangjylab.ustc.edu.cn/main.htm)至今,主要应用结构生物学、生物化学、分子生物学等方法解析着丝粒-动粒组装调控机制、组蛋白翻译后修饰的调控与识别机制、抗癌药物的作用机制等科学问题,揭示染色质高级结构动态调控的重要生理、病理意义,为相关疾病的药物研发提供理论依据。主要成果以(共)第一作者/通讯作者身份发表在Science Advances、Nature Communications、JACS、PNAS、Talanta、Cell Research、Cellular and molecular life sciences : CMLS等期刊。

研究领域

着丝粒-动粒的组装与调控机制 组蛋白翻译后修饰的识别与调控机制

近期论文

[1] 14. Eser, B. E.#, Zhang, X.#, Chanani, P. K., Begley, T. P.*, & Ealick, S. E.* From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis, Journal of the American Chemical Society 2016;138:3639-3642. [2] 13. Zhang Y#, Wu M#, Hang T#, Wang C, Yang Y, Pan W, Zang J, Zhang M* & Zhang X*. Staphylococcus aureus SdrE captures complement factor H's C-terminus via a novel 'close, dock, lock and latch' mechanism for complement evasion. Biochem J. 2017; 474: 1619-1631. [3] 12. Zhou X#, Zheng F#, Wang C#, Wu M, Zhang X, Wang Q, Yao X, Fu C, Zhang X* & Zang J*. Phosphorylation of CENP-C by Aurora B facilitates kinetochore attachment error correction in mitosis. Proc Natl Acad Sci U S A. 2017; 114: E10667-E10676. [4] 11. Tian T#, Li X#, Liu Y#, Wang C, Liu X, Bi G, Zhang X*, Yao X*, Zhou Z* & Zang J*. Molecular basis for CENP-N recognition of CENP-A nucleosome on the human kinetochore. Cell Res. 2018; 28: 374-378. [5] 10. Wang C#, Zhan L#, Wu M#, Ma R, Yao J, Xiong Y, Pan Y, Guan S, Zhang X* & Zang J*. Spindlin-1 recognizes methylations of K20 and R23 of histone H4 tail. FEBS Lett. 2018; 592: 4098-4110. [6] 9. Fang T#, Chen W#, Sheng Y, Yuan S, Tang Q, Li G, Huang G, Su J, Zhang X*, Zang J* & Liu Y*. Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein. Nat Commun. 2019; 10: 186. [7] 8. Hang T#, Chen W#, Wu M, Zhan L, Wang C, Jia N, Zhang X* & Zang J*. Structural insights into the molecular mechanism underlying Sirt5-catalyzed desuccinylation of histone peptides. Biochem J. 2019; 476: 211-223. [8] 7. Liu C#, Qi K#, Yao L, Xiong Y, Zhang X, Zang J, Tian C, Xu M, Yang J, Lin Z, Lv Y, Xiong W* & Pan Y*. Imaging of Polar and Nonpolar Species Using Compact Desorption Electrospray Ionization/Postphotoionization Mass Spectrometry. Anal Chem. 2019; 91: 6616-6623. (Q1 区,2019 IF 8.008). [9] 6. Zhang M#, Zheng F#, Xiong Y, Shao C, Wang C, Wu M, Niu X, Dong F, Zhang X*, Fu C* & Zang J*. Centromere targeting of Mis18 requires the interaction with DNA and H2A-H2B in fission yeast. Cell Mol Life Sci. 2021; 78: 373-384. [10] 5. Zhao J#, Chen W#, Pan Y#, Zhang Y, Sun H, Wang H, Yang F, Liu Y, Shen N*, Zhang X*, Mo X* & Zang J*. Structural insights into the recognition of histone H3Q5 serotonylation by WDR5. Sci Adv. 2021; 7. [11] 4. Jia N#, Li G, Wang X, Cao Q, Chen W, Wang C, Chen L, Ma X, Zhang X, Tao Y*, Zang J*, Mo X* & Hu J*. Staphylococcal superantigen-like protein 10 induces necroptosis through TNFR1 activation of RIPK3-dependent signal pathways. Commun Biol. 2022; 5: 813. [12] 3. Tian T#, Chen L#, Dou Z#, Yang Z#, Gao X*, Yuan X, Wang C, Liu R, Shen Z, Gui P, Teng M, Meng X, Hill DL, Li L, Zhang X, Liu X, Sun L*, Zang J* & Yao X*. Structural insights into human CCAN complex assembled onto DNA. Cell Discov. 2022; 8: 90. [13] 2. Zu H#, Li C#, Dai C#, Pan Y, Ding C, Sun H, Zhang X, Yao X*, Zang J* & Mo X*. SIRT2 functions as a histone delactylase and inhibits the proliferation and migration of neuroblastoma cells. Cell Discov. 2022; 8: 54. [14] 1. Zhan L#, Liu C#, Qi K, Wu L, Xiong Y, Zhang X*, Zang J* & Pan Y*. Enhanced imaging of endogenous metabolites by negative ammonia assisted DESI/PI mass spectrometry. Talanta. 2023; 252: 123864. [15] 7. Sasaki Eita,Zhang Xuan,Sun He G.,Lu Mei-Yeh Jade,Liu Tsung-lin,Ou Albert,Li Jeng-yi,Chen Yu-hsiang,Ealick Steven E.,Liu Hung-wen *,Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis,Nature,2014.6.19,510(7505):427~+。.2021, [16] 6. Eser Bekir E (#)., Zhang Xuan (#),Chanani Prem K.,Begley Tadhg P. (*),Ealick Steven E. (*), From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis, Journal of the American Chemical Society, 2016, 138 (11):3639~3642。.2021, [17] 5. Zhang Yingjie (#), Wu Minhao (#), Hang Tianrong (#), Wang Chengliang, Yang Ye, Pan Wenmin, Zang Jianye, Zhang Min (*), Zhang Xuan (*),Staphylococcus aureus SdrE captures complement factor H's C-terminus via a novel 'close, dock, lock and latch' mechanism for complement evasion,Biochemical Journal, 2017,474(10):1619-1631。.2021, [18] 3. Tian Tian (#), Li Xiaorun (#), Liu Yingying (#), Wang Chengliang,Liu Xing; Bi Guoqiang; Zhang Xuan (*); Yao Xiaobiao (*) ; Zhou Z.Hong (*) ; Zang Jianye (*), Molecular basis for CENP-N recognition of CENP-A nucleosome on the human kinetochore, Cell Research, 2018, 28: 374-378。.2021, [19] 2. Hang Tianrong (#), Chen Wanbiao (#), Wu Minhao, Zhan Li, Wang Chengliang, Jia Nan, Zhang Xuan (*), Zang Jianye (*), Structural insights into the molecular mechanism underlying Sirt5-catalyzed desuccinylation of histone peptides, Biochemical Journal, 2019, 476 (2):211-223。.2021, [20] 4. Zhou Xing (#),Zheng Fan(#),Wang Chengliang (#),Wu Minhao,Zhang Xiaozhen,Wang Qian,Yao Xuebiao,Fu Chuanhai,Zhang Xuan (*),Zang Jianye (*), Phosphorylation of CENP-C by Aurora B facilitates kinetochore attachment error correction in mitosis, Proceedings of the National Academy of Sciences of the United States of America, 2017.11, 114: E10667~E10676。.2021,