学习经历 2001.2-2003.12，中国科大统计与金融系概率论与数理统计专业（导师：应志良教授、赵林城教授），获理学博士学位。 1997.9-2000.6，中国科大数学系应用数学专业（导师：赵林城教授），获理学硕士学位。 1993.9-1997.6，中国科大数学系计算数学及其应用软件专业，获理学学士学位。 工作经历 2018.6至今，中国科大统计与金融系，教授、博导 2011.2-2018.5，复旦大学生物统计学研究所，研究员、博导 2000.7-2011，中国科大统计与金融系，助教/讲师 博士后研究 2009.1-2010.12，美国NIH国立癌症研究所（postdoctoral visiting fellow） 2006.8-2007.11，耶鲁大学医学院（postdoctoral associate） 2004.3-2005.4，乔治华盛顿大学统计系（postdoctoral scientist）

医学大数据分析、机器学习、遗传统计

Powerful Rare‐Variant Association Analysis of Secondary Phenotypes , Genetic Epidemiology , 2025 , 49e22589 Bayesian Inference of Dynamic Mediation Models for Longitudinal Data , Structural Equation Modeling: A Multidisciplinary Journal , 2024 , 31: 14-26 Riskbenefit trade-off of habitual physical activity and air pollution on mortality: a large-scale prospective analysis in the UK Biobank , Ecotoxicology and Environmental Safety , 2024 , 279116471 Efficient inference of parental origin effects using case-control mother-child geneotype data , Journal of Statistical Planning and Inference , 2024 , 233106190 Robust and powerful gene-environment interaction tests using rare genetic variants in case-control studies , Statistics and Its Interface , 2024 , 17: 51-62 Optimization of deep learning models for the prediction of gene mutations using unsupervised clustering , The Journal of Pathology: Clinical Research , 2023 , 9(1): 3-17 Methods and software to analyze gene-environment interactions under a case-mother - control-mother design with partially missing child genotype , Human Heredity , 2023 , 88: 38-49 FinBERT-MRC: financial named entity recognition using BERT under the machine reading comprehension paradigm , Neural Processing Letters , 2023 , 55: 7393-7413 Factor-analysis modeling and prediction for regressions with imaging biomarkers , Statistics in Medicine , 2023 , 42: 3616-3635 Prognostic significance of tumor-infiltrating lymphocytes determined using deep learning on colorectal cancer pathology images , JCO Precision Oncology , 2023 , 7e2200522 Predicting microsatellite instability and key biomarkers in colorectal cancer from H&E-stained images: Achieving SOTA predictive performance with fewer data using Swin Transformer , The Journal of Pathology: Clinical Research , 2023 , 9(3): 223-235 Estimation of genetic heritabilities of human traits in case-control studies , Annals of Human Genetics , 2023 , 87(3): 91-103 DPSeq: A Novel and Efficient Digital Pathology Classifier for Predicting Cancer Biomarkers using Sequencer Architecture, The American Journal of Pathology , The American Journal of Pathology , 2023 , 19312 A robust and lightweight deep attention multi-instance learning algorithm for predicting genetic alterations , Computerized Medical Imaging and Graphics , 2023 , 105102189 Causal effects of gut microbiota on erectile dysfunction: a two-sample Mendelian randomization study , Frontiers in Microbiology , 2023 , 141257114 Analysis of parent-of-origin effects for secondary phenotypes using case-control mother-child pair data , Genetic Epidemiology , 2022 , 46: 430-445 Colorectal cancer survival prediction using deep distribution based multiple-instance learning , Entropy , 2022 , 2424 Sequence coverage required for accurate genotyping by sequencing in polyploid species , Molecular Ecology Resources , 2022 , 22: 1417-1426 A retrospective analysis using deep learning models for prediction of survival outcome and benefit of adjuvant chemotherapy in stage IIIII colorectal cancer , Journal of Cancer Research and Clinical Oncology , 2022 , 148: 1955-1963 Ancient DNA and multimethod dating confirm the late arrival of anatomically modern humans in southern China , PNAS (Proceedings of the National Academy of Sciences of the United States of America) , 2021 , 118(8)e2019158118 Forecasting confirmed cases of the COVID-19 pandemic with a migration-based epidemiological model , Statistics and Its Interface , 2021 , 14(2): 59-71 Breast milk EPA associated with infant distractibility when EPA level is low , Nutrition , 2021 , 86111143 Covariate adjusted inference of parent-of-origin effects using case-control mother-child paired multilocus genotype data , Genetic Epidemiology , 2021 , 45: 830-847 Genetic affinity between Ningxia Hui and eastern Asian populations revealed by a set of InDel Loci , Royal Society Open Science , 2020 , 7: 190358-190358 An efficient and computationally robust statistical method for analyzing case-control mother-offspring pair genetic association studies , Annals of Applied Statistics , 2020 , 14(2): 560-584 contamDE-lm: linear model-based differential gene expression analysis using next-generation RNA-seq data from contaminated tumor samples , Bioinformatics , 2020 , 36(8): 2492-2499 存在非随机缺失数据的纵向数据中介分析 , 复旦学报（自然科学版） , 2024 , 63: 32-46 基于信息增益的加权贝叶斯插补法及其在心脏病类医疗缺失数据分析中的应用 , 复旦学报（自然科学版） , 2022 , 61(3): 335-341 Improving feature extraction from histopathological images through a fine-tuning ImageNet model , Journal of Pathology Informatics , 2022 , 13100115 Ｐ值的显式表达式及其概率分布性质 , 大学数学 , 2024 , 40(5): 81-84 Preoperative diagnosis of hepatocellular carcinoma patients with bile duct tumor thrombus using deep learning method , 中国科学技术大学学报 , 2022 , 52(12)6 An empirical-Bayes method for genetic association analysis using case-control mother-child pair data , 中国科学技术大学学报 , 2022 , 52(5)3 感染人数期望值估计及新增确诊人数趋势预测的概率模型 , 运筹学学报 , 2020 , 24(1): 1-12 组检验在差异化误分类下的最优性 , 应用概率统计 , 2024 , 40: 644-662