EDUCATION 1987 – 1992 Department of Biology, USTC, Undergraduate Student 1993 – 1995 Department of Biology, USTC, Graduate Student 1997 – 2000 Department of Biology, USTC and Université Paris-Sud, Ph.D student PROFESSIONAL EXPERIENCE 2000 – 2003 Postdoc, CNRS & Université Paris-Sud 2004 – Professor in Biochemistry, School of Life Sciences, USTC 2009 – 2014 Deputy Dean, School of Life Sciences, USTC 2014 – 2019 Dean, Office of Undergraduate Education, USTC 2019 – Provost, USTC

Structural insights into the transcriptional regulation of concerted carbon and nitrogen metabolism in cyanobacteria. Structure, assembly mechanism, molecular ecology and putative applications of freshwater cyanophages.

Fang FC, Wang L, Cheng MT, Xu D, Chen ZP, Wang J, Liao WL, Li YY, Zhou CZ*, Hou WT*, Chen YX*. Structural insights into human ABCA7-mediated lipid transport. Structure. 2025 Jan. Qurat A#, Kevin W#, Wu X, Bai Q, Li Q, Zhou CZ, Wu QF*. Cyanophage-Encoded Auxiliary Metabolic Genes (AMGs) in Modulating Cyanobacterial Metabolism and Algal Bloom Dynamics. Frontiers in Virology. 2024 Oct. Li Y, Chen ZP, Xu D, Wang L, Cheng MT, Zhou CZ, Chen YX*, Hou WT*. Structural insights into human ABCD3-mediated peroxisomal acyl-CoA translocation. Cell Discovery. 2024 Sep 3;10(1):92. Kong WW, Zhu Y, Zhao HR, Du K, Zhou RQ, Li B, Yang F, Hou P, Huang XH, Chen Y, Wang YC, Sun F*, Jiang YL*, Zhou CZ*. Cryo-electron tomography reveals the packaging pattern of RuBisCOs in Synechococcus β-carboxysome. Structure. 2024 May; S0969-2126(24)00184-9. Wang XQ, Du K, Chen C, Hou P, Li WF, Chen Y, Li Q*, Zhou CZ*. Profiling the interplay and coevolution of Microcystis aeruginosa and cyanosiphophage Mic1. Microbiology Spectrum. 2024 Jun; 12(6):e0029824. Zhou RQ#, Jiang YL#*, Li H, Hou P, Kong WW, Deng JX, Chen Y, Zhou CZ*, Zeng Q*. Structure and assembly of the α-carboxysome in the marine cyanobacterium Prochlorococcus. Nature Plants. 2024 Apr; 10(4):661-672. Yu RC, Yang F, Zhang HY, Hou P, Du K, Zhu J, Cui N, Xu X, Chen Y, Li Q*, Zhou CZ*. Structure of the intact tail machine of Anabaena myophage A-1(L). Nature Communications. 2024 Mar; 15(1):2654. Li B, Wang XQ, Li QY, Xu D, Li J, Hou WT, Chen Y*, Jiang YL*, Zhou CZ*. Allosteric regulation of nitrate transporter NRT via the signaling protein PII. Proceedings of the National Academy of Sciences USA. 2024 Mar; 121(11):e2318320121. Mao YX#, Chen ZP#, Wang L, Wang J, Zhou CZ*, Hou WT*, Chen Y*. Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain. Nature Communications. 2024 Feb; 15(1):1061. Han SJ, Jiang YL*, You LL, Shen LQ, Wu X, Yang F, Cui N, Kong WW, Sun H, Zhou K, Meng HC, Chen ZP, Chen Y, Zhang Y*, Zhou CZ*. DNA looping mediates cooperative transcription activation. Nature Structural & Molecular Biology. 2024 Feb; 31(2):293-299. Peng YJ, Chen Y, Zhou CZ, Miao W, Jiang YL*, Zeng X*, Zhang CC*. Modular catalytic activity of nonribosomal peptide synthetases depends on the dynamic interaction between adenylation and condensation domains. Structure. 2024 Jan; S0969-2126(24)00011-X. Sun CR#, Xu D#, Yang FR#, Hou ZH, Luo YY, Zhang CY, Shan G, Huang GM, Yao XB*, Chen Y*, Li Q*, Zhou CZ*. Human SIDT1 mediates dsRNA uptake via its phospholipase activity. Cell Research. 2024 Jan; 34(1):84-87. Jiang YL, Zhou CZ*. Multiple masks of a Shigella podophage. Structure. 2024 Jan; 32(1):1-2. [2023] Wang J, Li X, Wang FF, Cheng MT, Mao YX, Fang SC, Wang L, Zhou CZ*, Hou WT*, Chen Y*. Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket. The EMBO journal. 2023 Sep; 42(17):e113415. Chen Y, Wang L, Hou WT, Zha ZH, Xu K, Zhou CZ*, Li Q*, Chen YX*. Structural insights into human ABCC4-mediated transport of platelet agonist and antagonist. Nature Cardiovascular Research. 2023 Jun; 2:693–701 Yang F, Jiang YL*, Zhang JT, Zhu J, Du K, Yu RC, Wei ZL, Kong WW, Cui N, Li WF, Chen Y, Li Q*, Zhou CZ*. Fine structure and assembly pattern of a minimal myophage Pam3. Proceedings of the National Academy of Sciences USA. 2023 Jan; 120(4):e2213727120. Zhu J, Yang F, Du K, Wei ZL, Wu QF, Chen Y, Li WF*, Li Q*, Zhou CZ*. Phylogenomics of five Pseudanabaena cyanophages and evolutionary traces of horizontal gene transfer. Environmental Microbiome. 2023 Jan; 18(3):1-15. Wei ZL, Yang F, Li B, Hou P, Kong WW, Wang J, Chen Y, Jiang YL*, Zhou CZ*. Structural Insights into the Chaperone-Assisted Assembly of a Simplified Tail Fiber of the Myocyanophage Pam3. Viruses. 2022 Sep; 14(10):2260. Li Q#, Jiang YL#*, Xia LY#, Chen Y, Zhou CZ*. Structural insights into cyanobacterial RuBisCO assembly coordinated by two chaperones Raf1 and RbcX. Cell Discovery. 2022 Sep; 8(1):93. Hou WT, Xu D, Wang L, Chen Y, Chen ZP, Zhou CZ*, Chen Y*. Plastic structures for diverse substrates: A revisit of human ABC transporters. Proteins. 2022 Oct; 90(10):1749-1765. Du K, Yang F, Zhang JT, Yu RC, Deng ZQ, Li WF, Chen Y, Li Q*, Zhou CZ*. Comparative genomic analysis of five freshwater cyanophages and reference-guided metagenomic data mining. Microbiome. 2022 Aug; 10(1):128. Zhao F#, Lin X#, Cai K#, Jiang Y, Ni T, Chen Y, Feng J, Dang S, Zhou CZ*, Zeng Q*. Biochemical and structural characterization of the cyanophage-encoded phosphate-binding protein: implications for enhanced phosphate uptake of infected cyanobacteria. Environmental Microbiology. 2022 May; 24(7):3037-3050. Chen ZP, Xu D, Wang L, Mao YX, Li Y, Cheng MT, Zhou CZ*, Hou WT*, Chen Y*. Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1. Nature Communications. 2022 Jun; 13(1):3299. Cheng MT#, Chen Y#, Chen ZP, Liu X, Zhang Z, Chen Y*, Hou WT*, Zhou CZ*. Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding. Proceedings of the National Academy of Sciences USA. 2022 Apr; 119(14):e2118656119. Wang L#, Hou WT#, *, Wang J, Xu D, Guo C, Sun LF, Ruan K, Zhou CZ*, Chen Y*. Structures of human bile acid exporter ABCB11 reveal a transport mechanism facilitated by two tandem substrate-binding pockets. Cell Research. 2022 May; 32(5):501-504. Xu D, Li YY, Yang FR, Sun CR, Pan JH, Wang L, Chen ZP, Fang SC, Yao XB, Hou WT*, Zhou CZ*, Chen Y*. Structure and Transport Mechanism of the Human Cholesterol Transporter ABCG1. Cell Reports. 2022 Jan; 38(4):110298. Zhang JT, Yang F, Du K, Li WF, Chen Y, Jiang YL*, Li Q*, Zhou CZ*. Structure and assembly pattern of a freshwater short-tailed cyanophage Pam1. Structure. 2022 Feb; 30(2):240-251.e4 Cui N, Yang F, Zhang JT, Sun H, Chen Y, Yu RC, Chen ZP, Jiang YL, Han SJ, Xu XD*, Li Q*, Zhou CZ*. Capsid Structure of Anabaena Cyanophage A-1(L). Journal of Virology. 2021 Nov; 95(24):e0135621. Liu XY, Hou WT, Wang L, Li B, Chen Y, Chen Y*, Jiang YL*, Zhou CZ*. Structures of cyanobacterial bicarbonate transporter SbtA and its complex with PII-like SbtB. Cell Discovery. 2021 Aug; 7(1):63. Sun H, Cui N, Han SJ, Chen ZP, Xia LY, Chen Y, Jiang YL*, Zhou CZ*. Complex structure reveals CcmM and CcmN form a heterotrimeric adaptor in β‐carboxysome. Protein Science. 2021 Aug; 30(8):1566-1576. Xia LY#, Jiang YL#, Kong WW#, Sun H, Li WF, Chen Y*, Zhou CZ*. Molecular basis for the assembly of RuBisCO assisted by the chaperone Raf1. Nature Plants. 2020 Jun; 6(6):708-717. Cai K, Xu BY, Jiang YL, Wang Y, Chen Y, Zhou CZ, Li Q*. The model cyanobacteria Anabaena sp.PCC 7120 possess an intact but partially degenerated gene cluster encoding gas vesicles. BMC Microbiology. 2020 May; 20(1):110. Wang Y, Jin H, Yang F, Jiang YL, Zhao YY, Chen ZP, Li WF, Chen Y, Zhou CZ*, Li Q*. Crystal structure of a novel fold protein Gp72 from the freshwater cyanophage Mic1. Proteins. 2020 Sep; 88(9):1226-1232. Yang F, Jin H, Wang XQ, Li Q, Zhang JT, Cui N, Jiang YL, Chen Y, Wu QF*, Zhou CZ*, Li WF*. Genomic Analysis of Mic1 Reveals a Novel Freshwater Long-tailed Cyanophage. Frontiers in Microbiology. 2020 Apr; 11:484. Wang L#, Hou WT#, Chen L, Jiang YL, Xu D, Sun LF*, Zhou CZ*, Chen Y*. Cryo-EM structure of human bile salts exporter ABCB11. Cell Research. 2020 Jul; 30(7):623-625. Chen L#, Hou WT#, Fan T, Liu B, Pan T, Li YH, Jiang YL, Wen W, Chen ZP, Sun LF* Zhou CZ* , Chen Y *, Cryo-EM structure and transport mechanism of a wall teichoic acid ABC transporter. mBio. 2020 Mar; 11(2):e02749-19. Guo C#, Feng Z#, Zuo G, Jiang YL, Zhou CZ, Chen Y*, Hou WT*. Structural and functional insights into the Asp1/2/3 complex mediated secretion of pneumococcal serine-rich repeat protein PsrP. Biochemical and Biophysical Research Communications. 2020 Apr; 524(3):784-790.