许超 照片

许超

教授

所属大学: 中国科学技术大学

所属学院: 合肥微尺度物质科学国家研究中心

邮箱:
Xuchaor@ustc.edu.cn

个人主页:
https://biomed.ustc.edu.cn/2018/1008/c31898a570407/page.htm

个人简介

许超,男,教授,博士生导师。2000、2005年在中国科学技术大学生命科学学院分别获得本科及博士学位。2006-2008年在美国Mayo Clinic作博士后,2009-2015年在多伦多大学结构基因组联盟从事真核基因转录调控和RNA修饰的结构生物学研究。已发表SCI研究论文超过80篇,总引用4600余次(Web of Science)。其中 超 40篇为第一作者(含共同第一作者)或通讯作者,发表在Cell,Nature Chemical Biology, Nature Structural & Molecular Biology, Cell Research, PNAS, Nature Communications等期刊。

研究领域

运用结构生物学、化学生物学技术,结合分子生物学,生物物理学等方法,研究真核生物中生物大分子化学修饰,包括蛋白质翻译后修饰与核酸修饰产生、消除和识别的分子机制,以及这些修饰异常的致病(肿瘤和神经退行性疾病等)机理。并通过化学小分子筛选辅助药物设计达到控制或者治疗疾病的目的,积极推进从机制到药物开发的转化。

近期论文

1. #Chen X., #Raiff A., Li S., Guo Q., Zhang J., Zhou H., Timms R.T., Yao X., Elledge S.J., *Koren I., *Zhang K, *Xu C. Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase Nat. Commun. 15(1):3558. (2024). 2. #Zhao S., #Olmayev-Yaakobov D., Ru W., Li S., Chen X., Zhang J., Yao X., *Koren I., *Zhang K., *Xu C. Molecular basis for C-degron recognition by CRL2APPBP2 ubiquitin ligase. Proc Natl Acad Sci U S A. 120(43): e2308870120. (2023). 3. #Wang X., #Xie H., Guo Q., Cao D., Ru W., Zhao S., Zhu Z., Zhang J., Pan W., Yao X., *Xu C. Molecular basis for METTL9-mediated N1-histidine methylation. Cell Discov. 9(1):38. (2023). 4. #Chen Z., #Lundy T., Zhu Z., Hoskins V.E., Zhang J., Yao X., *Strahl B.D., *Xu C. Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4. Cell Discov. 9(1):51. (2023). 5. Guo Q., Chen X., *Xu C. TRIM-away via Gln/C-degrons. Nat. Chem. Biol. 18 (11), 1168-1169. (2022). 6. #Guo Q., #Zhao S., #Francisco-Velilla R., Zhang J., Embarc-Buh A., Abellan S., Lv M., Tang P., Gong Q., Shen H., Sun L., Yao X., Min J., Shi Y., *Martínez-Salas E., *Zhang K., *Xu C. Structural basis for Gemin5 decamer-mediated mRNA binding. Nat. Commun. 13:5166. (2022). 7. #Wang X., #Zeng C., #Liao S., Zhu Z., Zhang J., Tu X., Yao X., *Feng X., *Guang S., *Xu C. Molecular basis for PICS-mediated piRNA biogenesis and cell division. Nat. Commun. 12: 5595. (2021). 8. #Chen X., #Liao X., #Makaros Y, Guo Q., Zhu Z., Krizelman R., Dahan K., Tu X., Yao X., *Koren I., *Xu C. Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase. Nat. Chem. Biol. 17(3):254-262. (2021). 9. #Liao S., #Rajendraprasad G., #Wang N., Eibes S., Gao J., Yu H., Wu G., Tu X., *Huang H., *Barisic M. *Xu C. Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Res. 29, 533-547. (2019). 10. #Zeng C., #Weng C., #Wang X., #Yan Y., Li W., Xu D., Hong M., Liao S., Dong M., *Feng X., *Xu C., *Guang S. Functional proteomics identified a PICS complex required for piRNA maturation and chromosome segregation. Cell. Rep. 27, 3561-3572.e3 (2019). 11. #Guo Q., #Liao S., #Kwiatkowski S., Tomaka W., Yu H., Wu G., Tu X., Min J., *Drozak J., *Xu C. Structural insights into SETD3-mediated histidine methylation on β-actin. eLife 8, e43676. (2019). 12. *Xu C., Ishikawa H., Izumikawa K., Li L., He H., Nobe Y., Yamauchi Y., Shahjee M.H., Wu X., Yu Y., Isobe T., Takahashi N., *Min J. Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly. Genes Dev. 30, 2376-2390. (2016).