涂晓明 照片

涂晓明

副教授

所属大学: 中国科学技术大学

所属学院: 合肥微尺度物质科学国家研究中心

邮箱:
xmtu@ustc.edu.cn

个人主页:
https://biomed.ustc.edu.cn/2010/0630/c31900a570504/page.htm

个人简介

博士,副教授,博导,入选国家教育部“新世纪优秀人才支持计划”。1993年至2002年就读于中国科技大学生命科学学院并先后获学士,硕士和博士学位。2002年8月至2005年7月在美国加州大学旧金山分校从事博士后研究。2005年7月作为中国科技大学优秀人才引进,现为生命科学学院副教授。共发表论文22篇,其中以第一作者或通讯作者在Molecular Biology of the Cell、Journal of Cell Science、Journal of Biological Chemistry,Biochemical Journal等重要国际学术期刊发表研究论文14篇。

研究领域

锥体虫细胞周期调控的分子机制研究(国家自然科学基金项目,中科院创新项目子课题) Ubiquitin家族蛋白的结构和功能的研究(国家自然科学基金项目) 重要蛋白或蛋白结构域的结构和功能的研究(973子课题、863)

近期论文

1.Shanhui Liao, Wen Zhang, Kai Fan, Kaiqin Ye, Xuecheng Zhang, Jiahai Zhang, Chao Xu and Xiaoming Tu* (2013). Ionic strength-dependent conformations of a ubiquitin-like small archaeal modifier protein (SAMP2) from Haloferax volcanii. Scientific Reports. 3, 2136. (*通讯作者) 2.Tao Wang, Jiahai Zhang, Xuecheng Zhang, Chao Xu and Xiaoming Tu* (2013). Solution structure of the Big domain from Streptococcus pneumoniae reveals a novel Ca2+-binding module. Scientific Reports. 3, 1079. 3.Yu Qiu, Wen Zhang, Chen Zhao, Yan Wang, Weiwei Wang, Jiahai Zhang, Zhiyong Zhang, Guohong Li, Yunyu Shi, Xiaoming Tu* and Jihui Wu* (2012) Solution structure of Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA. Biochemical Journal. 442: 527-538. 4.Wen Zhang, Jiahai Zhang, Xuecheng Zhang, Chao Xu and Xiaoming Tu* (2011) Solution structure of Taf14 YEATS domain and its roles in cell growth of Saccharomyces cerevisiae. Biochemical Journal. 436: 83-90. 5.Shanhui Liao, Qiang Shang, Xuecheng Zhang, Jiahai Zhang, Chao Xu, Xiaoming Tu* (2009) Pup, a prokaryotic ubiquitin-like protein, is an intrinsically disordered protein. Biochemical Journal. Accelerated Publication. 422: 207-215. 6.Xiaoming Tu, Praveen Kumar, Ziyin Li and Ching C. Wang (2006) An Aurora Kinase Homologue is Involved in Mitosis and Cytokinesis in Trypanosoma brucei. J. Biol. Chem. 281:9677-9687. 7.Xiaoming Tu, Joel Mancuso, W. Zacheus Cande and Ching C. Wang (2005) Distinct cytoskeletal modulation and regulation of G1-S transition in the two life stages of Trypanosoma brucei. Journal of Cell Science. 118:4353-4364. 8.Xiaoming Tu and Ching C. Wang (2005) Coupling of Posterior Cytoskeletal Morphogenesis to the G1/S Transition in the Trypanosoma brucei Cell Cycle. Molecular Biology of the Cell. 16:97-105. 9.Xiaoming Tu and Ching C. Wang (2004) The involvement of two cdc2-related kinases (CRKs) in Trypanosoma brucei cell cycle regulation and the distinctive stage-specific phenotypes caused by CRK3 depletion. J. Biol. Chem. 279:20519-20528.