唐爱辉,中国科学技术大学生命科学与医学部和合肥微尺度物质国家实验室教授，国家创新人才青年项目获得者。实验室主要从事基于单分子成像的超分辨成像技术和空间转录组技术的开发和在神经生物学中的应用研究。在神经科学领域，主要关注突触传递和可塑性等基本神经生理学过程及其参与病理发生的机制，并做出突触纳米柱结构等重大发现。研究工作发表在Nature,Nature Methods,PNAS, Cell Reports等国际学术期刊上。承担包括基金委面上项目、科技部重大研究计划、科技部科技创新2030重大项目、中科院先导B等多项国家级项目。

空间多组学成像技术开发和应用 神经突触的结构功能重塑及其介导生理病理过程的机制

1. Sun SY, Nie LY, Fang X, Luo HM, Fu C, Wei Z, Tang AH (2025) The KIF21A-KANK1 interaction regulates dendritic morphology and synapse plasticity in neurons. Neural Regen Res. 20(1):209-223. 2. Chen JH#, Tang AH# (2023) Nanoscale reorganization of glutamate receptors underlies synaptic plasticity and pathology. Neurosci Bull. In press. 3. Xu N*, Cao R*, Chen SY, Gou XZ, Wang B, Luo HM, Gao F, Tang AH (2024) Structural and functional reorganization of inhibitory synapses by activity-dependent cleavage of neuroligin-2. Proc. Natl. Acad. Sci. U.S.A., 121(18): e2314541121. 4. Chen JH*#, Xu N*, Qi L, Yan HH, Wan FY, Gao, F, Fu C, Cang C, Lu B, Bi GQ, Tang AH# (2023) Reduced lysosomal density in neuronal dendrites mediates deficits in synaptic plasticity in Huntington’s disease. Cell Reports, 42(12): 113573. 5. He J, Liu K, Wu Y, Zhao C, Yan S, Chen JH, Hu L, Wang D, Zheng F, Wei W, Xu C, Huang C, Liu X, Yao X, Ding L, Fang Z#, Tang AH#, Fu C# (2023) The AAA-ATPase Yta4/ATAD1 interacts with Dnm1 and Fis1 to inhibit mitochondrial fission. Plos Bio., 21(8): e3002247. 6. Li D, Cao R, Li Q, Yang Y, Tang AH, Zhang J, Liu Q (2023) Nucleolus assembly impairment leads to two-cell transcriptional repression via NPM1-mediated PRC2 recruitment. Nat Struct Mol Biol, 30(7):914-925. 7. Zhu WH, Yang XX, Gou XZ, Fu SM, Chen JH, Gao F, Shen Y, Bi D#, Tang, AH# (2023) Nanoscale reorganization of synaptic proteins in Alzheimer’s disease. Neuropathol. Appl. Neurobiol. 49(4):e12924. 8. Li J*, Shang Z*, Chen JH* , Gu W*, Yao L*, Yang X, Sun X, Wang L, Wang T, Liu S, Li J, Hou T, Xing D, Gill DL, Li J, Wang SQ, Hou L, Zhou Y#, Tang AH#, Zhang X#, Wang Y# (2023) Engineering of NEMO as calcium indicators with large dynamics and high sensitivity. Nat Methods, 20: 918–924. 9. Han Y*, Cao R*, Qin L, Chen LY, Tang AH#, Südhof TC#, Zhang B# (2022) Neuroligin3 confines AMPA receptors in nanoclusters and controls synaptic strength at the calyx of Held. Sci Adv., 8(24): eabo4173. 10. Sarkar D, Kang J, Wassie AT, Schroeder ME, Peng Z, Tarr TB, Tang AH, Niederst ED, Young JZ, Su H, Park D, Yin P, Tsai LH, Blanpied TA, Boyden ES (2022) Revealing nanostructures in brain tissue via protein decrowding by iterative expansion microscopy. Nat Biomed Eng, 6(9):1057-1073. 11. Sun SY, Cao R, Zh Y, Sheng N#, Tang AH# (2022) Correlative assembly of subsynaptic nanoscale organizations during development. Front Synaptic Neurosci, 14:748184. 12.Gou XZ*, Ramsey AM*#, Tang AH# (2022) Re-examination of the determinants of synaptic strength from the perspective of superresolution imaging. Curr Opin Neurobiol, 74:102540. 13.Ramsey A*, Tang AH*, LeGates TA, Gou XZ, Carbone BE, Thompson SM, Biederer T and Blanpied TA (2021) Subsynaptic positioning of AMPARs by LRRTM2 controls synaptic strength. Sci Adv. 7(34): eabf3126. 14. Chen JH, Blanpied TA and Tang AH# (2020) Quantification of Trans-synaptic Protein Alignment: A Data Analysis Case for Single-molecule Localization Microscopy. Methods. 174: 72-80. 15. Chen H*, Tang AH*, and Blanpied TA# (2018) Subsynaptic spatial organization as a regulator of synaptic strength and plasticity. Curr. Opin. Neurobiol.51:147-153. 16. Mengistu M, Tang AH, Foulke, JS Jr., Blanpied TA, Gonzalez M, Spouge J, Lewis GK and DeVico AL# (2017) Patterns of Conserved gp120 Epitope Presentation on Attached HIV-1 Virions. Proc. Natl. Acad. Sci. U.S.A. 114(46):E9893-E9902. 17. Tang AH*#, Chen H*, Li TP, Metzbower SR, Mac Gillavry HD and Blanpied TA# (2016) A transsynaptic nanocolumn aligns neurotransmitter release to receptors. Nature. 536: 210–214. 18. Tang AH# and Alger BE (2015) Homer protein–metabotropic glutamate receptor binding regulates endocannabinoid signaling and affects hyperexcitability in a mouse model of Fragile X Syndrome. J Neurosci. 35(9):3938-45. 19. Tang AH, Karson MA, Nagode DA, McIntosh JM, Uebele VN, Renger JJ, Klugmann M, Milner TA, Alger BE# (2011) Nerve terminal nAChRs initiate quantal GABA release from perisomatic interneurons by activating axonal T-type (Cav3) Ca2+ channels and Ca2+ release from stores. J Neurosci, 31: 13546 - 13561. 20. Tang AH#, Wang SQ (2009) Transition of spiral calcium waves between multiple stable patterns can be triggered by a single calcium spark in a fire-diffuse-fire model. Chaos, 19: 037114-037114-6.