中国科学技术大学生命科学与医学部教授。2006 年获南京大学生物技术学士学位；2012 年获中国科学院上海生命科学研究院博士学位，中科院院长优秀奖；2013 年起，美国耶鲁大学遗传学系博士后。2014-2017年获美国 Leukemia and Lymphoma Society Fellow Award 和基金会研究资助。2018年底入职科大。研究方向为肿瘤多维度逃逸机制探索及新型干预策略设计。近五年(2020-2024)以通讯作者在Immunity, Cell Host Microbe, Cell Stem Cell, Nature Commun, Protein Cell, Mucosal Immunol, Elife上发表多篇研究论文及评论。研究工作多次被Nat Rev Immunol, Nat Med和Nat Immunol点评以及被 Faculty 1000 收录和推荐。以第一发明人申请国家发明专利4项。 教育工作经历 2002-2006年，南京大学生命科学学院，获学士学位 2006-2012年，中科院上海生命科学研究院健康科学研究所，获细胞生物学博士学位 2013-2018年，美国耶鲁大学医学院遗传系，博士后 2018年至今，中国科学技术大学生命科学与医学部，教授，博士生导师 获奖情况 2012年 中科院院长优秀奖 2014年 美国Leukemia and Lymphoma Society Fellow Award 2018年 中组部创新人才计划

肿瘤免疫治疗是肿瘤治疗领域一大创新成就。肿瘤免疫治疗重要手段之一，免疫检查点阻断治疗策略，获得2018年获得诺贝尔生理医学奖，针对性的anti-PD-1/L1抗体目前也是全世界年销售额最高的药物。尽管取得了辉煌的成就，但目前免疫检查点阻断治疗，在不同肿瘤类型中，仍然存在60%以上病人对于治疗不响应、无效，甚至在一些癌种比如结直肠癌，响应率不足10%。这提示肿瘤存在非常复杂的逃逸机制。如何寻找肿瘤新的逃逸机制？如何更好地针对这些逃逸机制设计靶向干预策略？从而更有效地提高病人对于免疫治疗的响应率？等等，是肿瘤免疫研究领域的痛点和热点，也是未来联合免疫疗法的重要方向。

1. Li C, Zhang P, Xie Y, Wang S, Guo M, Wei X, Zhang K, Cao D, Zhou R, Wang S, Song X#, Zhu S#, Pan W#.Enterococcus derived tyramine hijacks a2A-adrenergic receptor in intestinal stem cell to exacerbate colitis. Cell Host & Microbe. 2024 (IF=30.1) 2. Cong J*, Liu P*, Ying W, Li C, Han Z, Yang J, Song X, Dai L, Sun L, Kasper D, Pan W#, Zhu S#. Bile acids modified by the microbiota suppress gut anti-tumor immune responses. Immunity. 2024 (IF=43.5) 3. Zhu S#, Pan W#. Microbial metabolite steers intestinal stem cell fate under stress. Cell Stem Cell. 2024 (IF=23.9) 4. Ren X, Liu Q, Zhou P, Zhou T, Wang D, Mei Q, Flavell RA, Liu Z#, Li M#, Pan W#, Zhu S#. DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells. Nature Communications. 2024 (IF=16.6) 5. Wu Y, Zhang P, Shi T, Cao D#, Pan W# Deficiency of immunoglobulin IgSF6 enhances antibacterial effects by promoting endoplasmic reticulum stress and the inflammatory response in intestinal macrophages. Mucosal Immunology. 2024 (IF=8.7) 6. Dan Cao, Mengyue Lv, Chi Hu, Shukai Li, Siwen Wang, Chao Xu, Wen Pan#. METTL9-catalyzed histidine methylation of S100A9 suppresses the anti-Staphylococcus aureus activity of neutrophils. Protein & Cell. 2024 (IF=20.1) 7. A Wang, W Tao, J Tong, J Gao, J Wang, G Hou, C Qian, G Zhang, R Li, D Wang, X Ren, K Zhang, S Ding, R Flavell, HB Li, W Pan#, S Zhu#. m6A modifications regulate intestinal immunity and rotavirus infection. Elife. 2022 (IF=8.1) 8. M. Lv, D. Cao, L. Zhang, C. Hu, S. Li, P. Zhang, L. Zhu, X. Yi, C. Li, A. Yang, Z. Yang, Y. Zhu, K. Zhang, Pan, W#. METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth. Protein & Cell. 2021 (IF=20.1) 9. Pan, W., K. Qu, S. Zhu, K. Meeth, J. Cheng, H. Ma, Y. Liao, X. Wen, C. Roden, Z. Tobiasova, Z. Wei, J. Zhao, J. Liu, J. Zheng, B. Guo, M. Bosenberg, R.Flavell, J. Lu.The DNA methylcytosine dioxygenaseTet2 sustains immunosuppressive function of tumor-infiltrating myeloid cells to promote melanoma progression. Immunity. 2017. 47:284-297. (IF=43.5) 10. Zhu. S, S. Ding, P. Wang, Z. Wei, W. Pan, N. Palm, Y. Yang, H. Yu, H. Li, G. Wang, X. Lei, M. Zoete, J. Zhao, Y. Zheng, H. Chen, Y. Zhao, K. Jurado, N. Feng, L. Shan, Y. Kluger, J. Lu, C. Abraham, E. Fikrig, H. Greenberg, R. Flavell. Nlrp9b inflammasome recognizes and restricts enteric viral infection in intestinal epithelial cells. Nature. 2017. 546(7660):667-670 11. J Liu, B Guo, Z Chen, N Wang, M Iacovino, J Cheng, C Roden, W Pan, S. Khan, S. Chen, M. Kyba, R. Fan, S. Guo, Jun Lu. miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism. Blood. 2017. 12. C Roden, J Gaillard, S Kanoria, W Rennie, S Barish, J Cheng, W Pan, J. Liu, C. Cotsapas, Y. Ding, J. Lu. Novel determinants of mammalian primary microRNA processing revealed by systematic evaluation of hairpin-containing transcripts and human genetic variation. Genome research (2017) 27 (3), 374-384. 13. J. Cheng, C. Roden, W. Pan, S. Zhu, A. Baccei, X. Pan, T. Jiang, Y. Kluger, S. Weissman, S. Guo, R.Flavell, Y. Ding, J. Lu. A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions. Nature Communications. (2016) March 30; 7:11178. 14. Pan,W., D. Dai, S.Zhu, Z.Liu, D. Li, B.Li, Y.Tang, N. Gagliani, M. Weirauch, X. Chen, W. Zhu, Y. Qian, L.Richman, B. Jallal, J.B. Harley, R.Flavell, Y.Yao and N.Shen. MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis. Nature Communications. (2015) May 12.6:7096. 15. P.Wang, S.Zhu, L. Yang, S.Cui, W.Pan, R.Jackson, Y.Zheng, A.Rongvaux, LongYang, Q.Sun, G. Yang, S. Gao, R. Lin, F. You, R. Flavell, E. Fikrig. Nlrp6 regulates intestinal antiviral innate immunity. Science. 2015.