江永亮 照片

江永亮

副教授

所属大学: 中国科学技术大学

所属学院: 合肥微尺度物质科学国家研究中心

邮箱:
jyl@ustc.edu.cn

个人主页:
https://biox.ustc.edu.cn/2018/0301/c24191a473165/page.htm

个人简介

博士、中国科学技术大学副教授。2007年毕业于合肥工业大学生物技术专业获得理学学士学位,2012年毕业于中国科学技术大学生物化学与分子生物学专业获得理学博士学位。2012年6月在中国科学技术大学生命科学学院工作,先后从事博士后研究和担任特任副研究员。2018年1月通过中国科学技术大学优秀人才引进,受聘为生命科学学院副教授。主要研究方向为生物大分子结构和功能。研究成果以第一作者身份发表于PNAS、Nature Communications、PLoS Pathogens、JBC等国际著名期刊上。获首届中国科协“青年人才托举工程”资助。 教育与科研经历 2003.09-2007.07合肥工业大学,本科 2007.09-2012.06中国科学技术大学,博士 2012.06-2014.06中国科学技术大学,博士后 2014.06-2018.03中国科学技术大学,特任副研究员 2018.04-中国科学技术大学,副教授

研究领域

蓝细菌碳氮代谢协同调控的分子机理。 蓝细菌代谢相关重要蛋白质复合物的结构生物学研究。 细菌重要膜转运蛋白的结构和功能研究。

近期论文

Kong WW, Zhu Y, Zhao HR, Du K, Zhou RQ, Li B, Yang F, Hou P, Huang XH, Chen Y, Wang YC, Sun F*, Jiang YL*, Zhou CZ*. Cryo-electron tomography reveals the packaging pattern of RuBisCOs in Synechococcus β-carboxysome. Structure. 2024 May; S0969-2126(24)00184-9. Wang XQ, Du K, Chen C, Hou P, Li WF, Chen Y, Li Q*, Zhou CZ*. Profiling the interplay and coevolution of Microcystis aeruginosa and cyanosiphophage Mic1. Microbiology Spectrum. 2024 Jun; 12(6):e0029824. Zhou RQ#, Jiang YL#. Structure of intact α-carboxysome specifies role of CsoS2 in shell assembly. Nature Plants. 2024 Apr; 10(4):535-536. Zhou RQ#, Jiang YL#*, Li H, Hou P, Kong WW, Deng JX, Chen Y, Zhou CZ*, Zeng Q*. Structure and assembly of the α-carboxysome in the marine cyanobacterium Prochlorococcus. Nature Plants. 2024 Apr; 10(4):661-672. Li B, Wang XQ, Li QY, Xu D, Li J, Hou WT, Chen Y*, Jiang YL*, Zhou CZ*. Allosteric regulation of nitrate transporter NRT via the signaling protein PII. Proceedings of the National Academy of Sciences USA. 2024 Mar; 121(11):e2318320121. Mao YX#, Chen ZP#, Wang L, Wang J, Zhou CZ*, Hou WT*, Chen Y*. Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain. Nature Communications. 2024 Feb; 15(1):1061. Han SJ, Jiang YL*, You LL, Shen LQ, Wu X, Yang F, Cui N, Kong WW, Sun H, Zhou K, Meng HC, Chen ZP, Chen Y, Zhang Y*, Zhou CZ*. DNA looping mediates cooperative transcription activation. Nature Structural & Molecular Biology. 2024 Feb; 31(2):293-299. Peng YJ, Chen Y, Zhou CZ, Miao W, Jiang YL*, Zeng X*, Zhang CC*. Modular catalytic activity of nonribosomal peptide synthetases depends on the dynamic interaction between adenylation and condensation domains. Structure. 2024 Jan; S0969-2126(24)00011-X. Jiang YL, Zhou CZ*. Multiple masks of a Shigella podophage. Structure. 2024 Jan; 32(1):1-2. [2023] Yang F, Jiang YL*, Zhang JT, Zhu J, Du K, Yu RC, Wei ZL, Kong WW, Cui N, Li WF, Chen Y, Li Q*, Zhou CZ*. Fine structure and assembly pattern of a minimal myophage Pam3. Proceedings of the National Academy of Sciences USA. 2023 Jan; 120(4):e2213727120. Wei ZL, Yang F, Li B, Hou P, Kong WW, Wang J, Chen Y, Jiang YL*, Zhou CZ*. Structural Insights into the Chaperone-Assisted Assembly of a Simplified Tail Fiber of the Myocyanophage Pam3. Viruses. 2022 Sep; 14(10):2260. Li Q#, Jiang YL#*, Xia LY#, Chen Y, Zhou CZ*. Structural insights into cyanobacterial RuBisCO assembly coordinated by two chaperones Raf1 and RbcX. Cell Discovery. 2022 Sep; 8(1):93. Zhang JT, Yang F, Du K, Li WF, Chen Y, Jiang YL*, Li Q*, Zhou CZ*. Structure and assembly pattern of a freshwater short-tailed cyanophage Pam1. Structure. 2022 Feb; 30(2):240-251.e4 Wang X#, Cheng MT#, Chen ZP, Jiang YL, Ge YS, Xia R*, Hou WT*. Structural and biochemical analyses of the tetrameric carboxypeptidase S9Cfn from Fusobacterium nucleatum. Acta Crystallogr D Struct Biol. 2021 Dec; 77(Pt 12):1554-1563. Cui N, Yang F, Zhang JT, Sun H, Chen Y, Yu RC, Chen ZP, Jiang YL, Han SJ, Xu XD*, Li Q*, Zhou CZ*. Capsid Structure of Anabaena Cyanophage A-1(L). Journal of Virology. 2021 Nov; 95(24):e0135621. Liu XY, Hou WT, Wang L, Li B, Chen Y, Chen Y*, Jiang YL*, Zhou CZ*. Structures of cyanobacterial bicarbonate transporter SbtA and its complex with PII-like SbtB. Cell Discovery. 2021 Aug; 7(1):63. Sun H, Cui N, Han SJ, Chen ZP, Xia LY, Chen Y, Jiang YL*, Zhou CZ*. Complex structure reveals CcmM and CcmN form a heterotrimeric adaptor in β‐carboxysome. Protein Science. 2021 Aug; 30(8):1566-1576. Xia LY#, Jiang YL#, Kong WW#, Sun H, Li WF, Chen Y*, Zhou CZ*. Molecular basis for the assembly of RuBisCO assisted by the chaperone Raf1. Nature Plants. 2020 Jun; 6(6):708-717. Cai K, Xu BY, Jiang YL, Wang Y, Chen Y, Zhou CZ, Li Q*. The model cyanobacteria Anabaena sp.PCC 7120 possess an intact but partially degenerated gene cluster encoding gas vesicles. BMC Microbiology. 2020 May; 20(1):110. Wang Y, Jin H, Yang F, Jiang YL, Zhao YY, Chen ZP, Li WF, Chen Y, Zhou CZ*, Li Q*. Crystal structure of a novel fold protein Gp72 from the freshwater cyanophage Mic1. Proteins. 2020 Sep; 88(9):1226-1232. Yang F, Jin H, Wang XQ, Li Q, Zhang JT, Cui N, Jiang YL, Chen Y, Wu QF*, Zhou CZ*, Li WF*. Genomic Analysis of Mic1 Reveals a Novel Freshwater Long-tailed Cyanophage. Frontiers in Microbiology. 2020 Apr; 11:484. Wang L#, Hou WT#, Chen L, Jiang YL, Xu D, Sun LF*, Zhou CZ*, Chen Y*. Cryo-EM structure of human bile salts exporter ABCB11. Cell Research. 2020 Jul; 30(7):623-625. Chen L#, Hou WT#, Fan T, Liu B, Pan T, Li YH, Jiang YL, Wen W, Chen ZP, Sun LF* Zhou CZ* , Chen Y *, Cryo-EM structure and transport mechanism of a wall teichoic acid ABC transporter. mBio. 2020 Mar; 11(2):e02749-19. Guo C#, Feng Z#, Zuo G, Jiang YL, Zhou CZ, Chen Y*, Hou WT*. Structural and functional insights into the Asp1/2/3 complex mediated secretion of pneumococcal serine-rich repeat protein PsrP. Biochemical and Biophysical Research Communications. 2020 Apr; 524(3):784-790.