个人简介
个人简介 2012.1-现在 中国科技大学 化学系 2008.8-2011.12 加州大学圣巴巴拉分校,博士后 2007.8-2008.7 加州大学伯克莱分校,博士后 2002.9-2007.6中科院上海有机化学研究所, 博士 1998.9-2002.6 南京大学化学系, 学士 教育经历 1998.9-2002.6 南京大学化学系, 学士 2002.9-2007.6 中科院上海有机化学研究所, 博士 工作经历 2007.8-2008.7 加州大学伯克莱分校,博士后 2008.8-2011.12 加州大学圣巴巴拉分校,博士后 2012.1-现在 中国科技大学 化学系
研究领域
有机合成方法学(金属导向的有机合成)及其在复杂天然产物合成中的应用
近期论文
Base-Promoted Coupling of HFIP in Cu-Catalyzed Asymmetric Ring Opening of Cyclic Diaryliodoniums, Abdur Rahim, Biqiong Hong*, Zhenhua Gu*, J. Org. Chem., 2024 DOI:10.1021/acs.joc.4c02426. Coplanar Atropochiral 5H-Cyclopenta[2,1-b:3,4-b']dipyridine Ligands: Synthesis and Applications in Asymmetric Ring-Opening Reaction, Han Yang, Xiaojie Sun, Zhen Chen, Chenming Jiang, Longhui Duan, Jinbo Zhao, Zhenhua Gu*, Angew. Chem. Int. Ed., 2024,e202416839. DOI:10.1002/anie.202416839. Quaternary Chiral Phthalides Enabled by Dirhodium(II)/Phosphine Catalyzed Asymmetric Carbonyl Addition Cascade, Shuming Zhan, Heng Xu, Biqiong Hong*, Zhenhua Gu*, Org. Lett., 2024, 26,8023–8027 DOI:10.1021/acs.orglett.4c02765. Spatial decoupling of bromide-mediated process boosts propylene oxide electrosynthesis, Mingfang Chi, Jingwen Ke, Yan Liu, Miaojin Wei, Hongliang Li, Jiankang Zhao, Yuxuan Zhou, Zhenhua Gu, Zhigang Geng* and Jie Zeng*, Nat. Commun., 2024, 15, 3646. DOI:10.1038/s41467-024-48070-1. [1] Conjugation-Induced Spin Delocalization in Helical Chiral Carbon Radicals via Through-Bond and Through-Space Effects.Adv. Sci. 2023, 10, 202304563,2023, [2] Preparation of Optically Active 2,2'-Dibromo-6,6'-diiodo-1,1'-biphenyl: A Powerful Precursor for Modular Synthesis of Functionalized Atropisomers.Chin. J. Chem. 2023, 41, 3515—3520,2023, [3] Expanding the Potential of 3-Hydroxyindolinones: Synthesis of Quinoxalin-2(1H)-ones through Acid-Promoted Azidation and Ring-Expansion.Adv. Synth. Catal. 2023, 365, 1-6,2023, [4] A Chiral Relay Race: Stereoselective Synthesis of Axially Chiral Biaryl Diketones through Ring-Opening of Optical Dihydrophenan-threne-9,10-diols.Molecules, 2023, 28(16), 5956,2023, [5] Synthesis of atropisomers via transition-metal-catalyzed enantioselective carbene transformations.Trends in Chemistry, September 2023, Vol. 5, No. 9,2023, [6] Stereoselective Synthesis Axially Chiral Arylnitriles through Base-Induced Chirality-Relay β-Carbon Elimination of α-Hydroxyl Ketoxime Esters.Org. Lett. 2023, 25, 20, 3602–3606,2023, [7] Confronting the Challenge of Asymmetric Carbonyl Addition to Sterically Bulky Isatins: Upgrading Dirhodium(II)/Biphosphine Catalytic System.Org. Lett. 2023, 25, 18, 3281–3286,2023, [8] Atroposelective Three-Component Coupling of Cyclic Diaryliodoniums and Sodium Cyanate Enabled by the Dual-Role of Phenol Shan Yang, Tianze Zheng, Longhui Duan, Xiaoping Xue,and Zhenhua Gu*.Angew. Chem. Int. Ed.2023, e202302749,2023, [9] Dirhodium(II)/Phosphine Catalyst with Chiral Environment at Bridging Site and Its Application in Enantioselective Atropisomer Synthesis Lei Shi, Xiaoping Xue, Biqiong Hong, Qigang Li, and Zhenhua Gu*.ACS Cent. Sci. 2023.,2023, [10] Divergent Synthesis of Helical Ketone Enabled by Rearrangement of Spiro Carbocation Limin Wang, Longhui Duan, Biqiong Hong, and Zhenhua Gu*.Org. Lett. 2023,2023, [11] Recent Progress in Cyclic Aryliodonium Chemistry: Syntheses and Applications Xiaopeng Peng, Abdur Rahim, Weijie Peng, Feng Jiang, Zhenhua Gu*, and Shijun Wen*.Chem. Rev. 2023, 123, 4, 1364–1416,2023, [12] Synthesis of Atropisomers with Biaryl and Vinylaryl Chirality via Pd-Catalyzed Point-to-Axial Chirality Transfer Ring-Opening Reaction Jian Gu, Biqiong Hong, Xiaoping Xue, Junwei Xi, and Zhenhua Gu*.Org. Lett. 2022, 24, 49, 9097–9101,2022, [13] Nitrenoid from Oxime: A Practical Synthesis of Planar Chiral Ferrocenyl Phenanthridines via Nitrene-Involved Ring-Expansion Reaction Na Li, Biqiong Hong, Jinbo Zhao* and Zhenhua Gu*.Angew. Chem.Int. Ed .2023,62, e2022155,2022, [14] From Peripheral Stereogenic Center to Axial Chirality: Synthesis of 3-Arylthiophene Atropisomers Lin Li, Junwei Xi, Biqiong Hong, Zhenhua Gu*.Adv. Synth.Catal.2022,364, 1–7,2022, [15] Synthesis of 2-Aryl Azetidines through Pd-Catalyzed Migration/Coupling of 3-Iodoazetidines and Aryl Boronic Acids Han Yang, Zhen Chen, Wenjing Guo, and Zhenhua Gu*.Org. Lett.2022, 24, 31, 5731–5735,2022, [16] Transition Metal-Catalyzed Biaryl Atropisomer Synthesis via a Torsional Strain Promoted Ring-Opening Reaction, Xue Zhang, Kun Zhao, and Zhenhua Gu*.Acc. Chem. Res.2022, 55, 12, 1620–1633,2022, [17] Paddlewheel dirhodium(II) complexes with N-heterocyclic carbene or phosphine ligand: New reactivity and selectivity, Biqiong Hong, Lei Shi, Lin Li, Shuming Zhan, and Zhenhua Gu*.Green Synthesis and Catalysis., 2022, 3, 137-149.,2022, [18] Atroposelective Kinetic Resolution of 8H-Indeno[1,2-c]thiophen-8-ols via Pd-Catalyzed C–C Bond Cleavage Reaction, Junwei Xi, Han Yang, Lin Li, Xue Zhang, Chunyu Li, and Zhenhua Gu*.Org. Lett., 2022, 24, 2387–2392.,2022, [19] Torsional strain inversed chemoselectivity in a Pd-catalyzed atroposelective carbonylation reaction of dibenzothiophenium, Qiuchi Zhang, Xiaoping Xue, Biqiong Hong, and Zhenhua Gu*.Chem. Sci. , 2022, 13, 3761-3765.,2022, [20] Synthesis of 2-Hydroxy-2′-aroyl-1,1′-biaryls via Oxidative Ring-Opening of 9H-Fluoren-9-ols, Xiaoping Xue, Biqiong Hong, Jia Feng, and Zhenhua Gu*.Org. Lett., 2021, 24, 496-500.,2021, [21] Construction of 2-Amino-2′-ketonyl Biaryls via Acid-Mediated Ring Opening of 9H-Fluoren-9-ols with Organic Azides, Shan Yang, Biqiong Hong, Jia Feng, and Zhenhua Gu*.Org. Lett., 2021, 23, 9179–9183.,2021, [22] Ring-Expansion Strategy for α-Aryl Azahelicene Construction: Building Blocks for Optoelectronic Materials, Jia Feng, Limin Wang, Xiaoping Xue, Zengyin Chao, Biqiong Hong, and Zhenhua Gu*.Org. Lett., 2021, 23, 8056–8061.,2021, [23] Synthesis of Planar Chiral 2-Aryl Aroylferrocenes via Palladium-Catalyzed C–C Bond-Cleavage/Ring-Opening Reaction, Zengyin Chao, Na Li, Biqiong Hong, Mingming Ma*, and Zhenhua Gu*.Org. Lett., 2021, 23, 7759−7764.,2021, [24] Construction of Axial Chirality and Silicon-Stereogenic Center via Rh-Catalyzed Asymmetric Ring-Opening of Silafluorenes, Xiufen Bi, Jia Feng, Xiaoping Xue, and Zhenhua Gu*.Org. Lett., 2021, 23, 3201−3206.,2021, [25] Enantioselective preparation of atropisomeric biaryl trifluoromethylsulfanes via ring-opening of cyclic diaryliodoniums, Longhui Duan, Zhonggui Wang, Kun Zhao and Zhenhua Gu*.Chem. Commun., 2021, 57, 3881–3884.,2021, [26] Atropisomerism in Styrene: Synthesis, Stability, and Applications, Jia Feng and Zhenhua Gu*.SynOpen, 2021, 05, 68-85.,2021, [27] Diols Activation via Cu/Borinic Acids Synergistic Catalysis in Atroposelective Ring‐Opening of Cyclic Diaryliodoniums, Kun Zhao†, Shan Yang†, Qi Gong, Longhui Duan, and Zhenhua Gu*.Angew. Chem. Int. Ed., 2021, 60, 5788–5793.,2020, [28] Transition‐Metal‐Catalyzed Carbon‐Carbon Bond Activation in Asymmetric Synthesis, Xiufen Bi, Qiuchi Zhang, and Zhenhua Gu*.Chin. J. Chem., 2021, ASAP.,2020, [29] Catalytic Asymmetric Synthesis of Atropisomeric Nitrones: Versatile Intermediate for Axially Chiral Biaryls, Wenjing Guo, Jian Gu, and Zhenhua Gu*.Org. Lett., 2020, 22, 7622–7628.,2020, [30] Catalytic asymmetric C–Si bond activation via torsional strain-promoted Rh-catalyzed aryl Narasaka acylation, Jia Feng†, Xiufen Bi†, Xiaoping Xue, Na Li, Lei Shi and Zhenhua Gu*.Nat. Commun., 2020, 11, 4449.,2020,