郭昌 照片

郭昌

教授

所属大学: 中国科学技术大学

所属学院: 合肥微尺度物质科学国家研究中心

邮箱:
guochang@ustc.edu.cn

个人主页:
http://www.hfnl.ustc.edu.cn/detail?id=11355

个人简介

2018.03 - 至今 特任教授,博士生导师,合肥微尺度物质科学国家研究中心 2017.02-2018.02 特任研究员,中国科学技术大学,合肥微尺度物质科学国家研究中心 2013.08-2017.01 博士后,德国明斯特大学 2007.09-2013.06 博士,中国科学技术大学 2003.08-2007.06 学士,中国科学技术大学

研究领域

研究方向:电化学合成,不对称催化,研究工作包括不对称电化学反应、联合催化、天然产物全合成。以新型不对称催化研究为基础提高反应活性与选择性,并将这些方法学用于天然产物的合成,发展高效、原子经济性和环境友好的现代有机合成化学

近期论文

Enantioselective electrocatalysis for the cross-dehydrogenative heteroarylation of indoles, pyrroles, and furans Liang, K.; Li, N.; Liu, M; Song, J.; Guo, C.* Angew. Chem. Int. Ed. 2024, 63, e202415723 Enantioselective nickel-electrocatalyzed reductive propargylic carboxylation with CO2 Hu, Q.; Wei, B.; Wang, M.; Liu, M.; Chen, X.-W.; Ran, C.-K.; Wang, G.; Chen, Z.; Li, H.; Song, J.; Yu, D.-G.*; Guo, C.* J. Am. Chem. Soc. 2024, 146, 14864–14874 Enantioselective nickel-catalyzed anodic oxidative dienylation and allylation reactions Zhang, Q.; Zhang, J.; Zhu, W.; Lu, R.; Guo, C.* Nat. Commun. 2024, 15, 4477 Dual-catalyzed stereodivergent electrooxidative homocoupling of benzoxazolyl acetate Zhang, J.; Zhu, W.; Chen, Z.; Zhang, Q.; Guo, C.* J. Am. Chem. Soc. 2024, 146, 1522 Ni/Cu dual-catalyzed propargylation for the stereodivergent synthesis of Methohexital Chang, X.*; Zhang, J.; Cheng, X.; Lv, X.; Guo, C.* Adv. Sci. 2024, 2406764 Xu, X.; Wang, M.; Peng, L.; Guo, C.* Nickel-catalyzed asymmetric propargylation for the synthesis of axially chiral 1,3-disubstituted allenes. J. Am. Chem. Soc. 2022, 144, 21022―21029. 2.Zhang, J.; Chang, X.; Xu, X.; Wang, H.; Peng, L.; Guo, C.* Nickel-catalyzed switchable 1,3-dienylation and enantioselective allenylation of phosphine oxides. Nat. Commun. 2022, 13, 7049. 3.Liang, K.; Zhang, Q.; Guo, C.* Nickel-catalyzed switchable asymmetric electrochemical functionalization of alkenes. Sci. Adv. 2022, 8, eadd7134. 4.Zhang, Q.; Liang, K.; Guo, C.* Enantioselective nickel-catalyzed electrochemical radical allylation. D. Angew. Chem. Int. Ed. 2022, 61, e202210632. 5.He, Z.; Peng, L.; Guo, C.* Catalytic stereodivergent total synthesis of amathaspiramide D. Nat. Synth. 2022, 1, 393-400. 6.Hu, Q.; He, Z.; Peng, L.; Guo, C.* Combining nickel and squaramide catalysis for the stereodivergent α-propargylation of oxindoles. Nat. Synth. 2022, 1, 322-331. 7.Xu, X.; Peng, L.; Chang, X.; Guo, C.* Ni/Chiral Sodium Carboxylate Dual Catalyzed Asymmetric O-Propargylation. J. Am. Chem. Soc. 2021, 143, 21048-21055. 8.Peng, L.; Wang, H.; Guo, C.* Copper-Catalyzed Enantioselective Difluoromethylation of Amino Acids via Difluorocarbene. J. Am. Chem. Soc. 2021, 143, 6376―6381. 9.Chang, X.; Zhang, J.; Peng, L.; Guo, C.* Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation. Nat. Commum. 2021, 12, 299. 10.Zhang, Q.; Liang, K.; Guo, C.* Asymmetric Electrochemical Arylation in the Formal Synthesis of (+)-Amurensinine. CCS Chem. 2021, 3, 338. 11.Chang, X.; Zhang, J.; Zhang, Q.; Guo, C.* Merging Electrosynthesis and Bifunctional Squaramide Catalysis in the Asymmetric Detrifluoroacetylative Alkylation Reactions. Angew. Chem. Int. Ed. 2020, 59, 18500―18504. 12.Peng, L.; He, Z.; Xu, X.; Guo, C.* Cooperative Ni/Cu-Catalyzed Asymmetric Propargylic Alkylation of Aldimine Esters. Angew. Chem. Int. Ed. 2020, 59, 14270―14274. 13.Chang, X.; Zhang, Q.; Guo, C.* Asymmetric Electrochemical Transformation. Angew. Chem. Int. Ed. 2020, 59, 12612―12622. 14.Wang, H.; Hu, Q.; Wang, M.; Guo, C.* Enantioselective [4+2] Annulation to the Concise Synthesis of Chiral Dihydrocarbazoles. iScience 2020, 23, 100840. 15.Zhang, Q.; Chang, X.; Peng, L.; Guo, C.* Asymmetric Lewis Acid Catalyzed Electrochemical Alkylation. Angew. Chem. Int. Ed. 2019, 58, 6999―7003. 16.Chang, X.; Zhang, Q.; Guo, C.* Switchable Smiles Rearrangement for Enantioselective O-Aryl Amination. Org. Lett. 2019, 21, 4915―4918. 17.Wang, H.; Guo, C.* Enantioselective γ‐Addition of Pyrazole and Imidazole Heterocycles to Allenoates Catalyzed by Chiral Phosphine. Angew. Chem. Int. Ed. 2019, 58, 2854―2858. 18.Chang, X.; Zhang, Q.; Guo. C.* Electrochemical Reductive Smiles Rearrangement for C−N Bond Formation. Org. Lett. 2019, 21, 10―13. 19.Guo, C.*; Janssen-Müller, D.; Fleige, M.; Lerchen, A.; Daniliuc, C. G.; Glorius, F.*Mechanistic studies on a cooperative NHC organocatalysis/palladium catalysis system: uncovering significant lessons for mixed chiral Pd(NHC)(PR3) catalyst design. J. Am. Chem. Soc. 2017, 139, 4443―4451. 20.Guo, C.; Fleige, M.; Janssen-Müller, D.; Daniliuc, C. G.; Glorius, F.* Cooperative N-heterocyclic carbene/palladium-catalyzed enantioselective umpolung annulations, J. Am. Chem. Soc. 2016, 138, 7840―7843. 21.Guo, C.; Fleige, M.; Janssen-Müller, D.; Daniliuc, C. G.; Glorius, F. * Switchable selectivity in an NHC-catalysed dearomatizing annulation reaction, Nat. Chem. 2015, 7, 842―847. 22.Guo,C.; Sahoo, B.; Daniliuc, C. G.; Glorius, F.*N-Heterocyclic carbene catalyzed switchable reactions of enals with azoalkenes: formal [4+3] and [4+1] annulations for the synthesis of 1,2-diazepines and pyrazoles, J. Am. Chem. Soc. 2014, 136, 17402―17405. 23.Guo, C.; Schedler, M.; Daniliuc, C. G.; Glorius,F.*N-Heterocyclic carbene catalyzed formal [3+2] annulation reaction of enals: an efficient enantioselective access to spiro-heterocycles, Angew. Chem. Int. Ed. 2014, 53, 10232―10236.