教育背景： 1983.09 - 1988.07，山东医科大学，医学，学士 1991.09 - 1997.03，日本大阪大学医学部，医学，博士 工作经历： 1988.08 - 1990.03，山东医科大学附属医院，医师 1997.04 - 1998.09，大阪大学医学部生物医学研究中心，博士后 1998.10 - 1999.11，中国海洋大学医药学院，副教授 1999.12 - 至今，中国海洋大学医药学院，教授 获奖荣誉： 2003 年，国家海洋局海洋创新成果二等奖（第二位） 2008 年，高等学校技术发明一等奖（第五位） 2009 年，国家技术发明一等奖（第三位） 2013 年，青岛专业技术拔尖人才 2015 年，享受国务院特殊津贴专家

海洋微生物分子酶学 蛋白质糖基化修饰与疾病发生发展 新型抗感染药物的研究

Gong Gao, Minghui Shi, Ruihong Wang, Chaojie Wang, Changlun Shao, Yuchao Gu*, Wengong Yu*.A widely compatible expression system for the production of highly O-GlcNAcylated recombinant protein in Escherichia coli.Glycobiology, 2018, 28 (12): 949–957. Weibin Zhang, Jingnan Xu, Dan Liu, Huan Liu, Xinzhi Lu*, Wengong Yu*. Characterization of an α-agarase from Thalassomonas sp. LD5 and its hydrolysate. Appl Microbiol Biotechnol, 2018, 102(5): 2203-2212. Yujuan Han, Rilei Yu, Peixin Gao, Xinzhi Lu*, Wengong Yu*. The hydrogen-bond network around Glu160 contributes to the structural stability of chitosanase CsnA from Renibacterium sp. QD1. Int J Biol Macromol, 2018, 109: 880-887. Cuifang Han, Yuchao Gu*, Hui Shan, Wenyi Mi, Jiahui Sun, Minghui Shi, Xinling Zhang, Xinzhi Lu, Feng Han, Qianhong Gong, Wengong Yu*. O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress. Nat Commun, 2017,8(1):1491. Cuifang Han, Hui Shan, Chuanlin Bi, Xinling Zhang, Jieqiong Qi, Boyuan Zhang, Yuchao Gu*, Wengong Yu*.A highly effective and adjustable dual plasmid system for O-GlcNAcylated recombinant protein production in E. coli.Journal of Biochemistry, 2015, 157(6):477-484. Shuai Man, Rubin Cheng, Cuicui Miao, Qianhong Gong, Yuchao Gu, Xinzhi Lu, Feng Han, andWengong Yu*. Artificial trans-encoded small noncoding RNAs specifically silence the selected gene expression in bacteria. Nucleic Acids Res, 2011, 39(8):e50. Yulong Tan, Feng Han, Su Ma, Wengong Yu*. Carboxymethyl chitosan prevents formation of broad-spectrum biofilm.CarbohydrPolym, 2011, 84(4): 1365-1370. Wenyi Mi, Yuchao Gu, Cuifang Han, Haiyan Liu, Qiong Fan, Xinling Zhang, Qi Cong, and Wengong Yu*. O-GlcNAcylation is a novel regulator of lung and colon cancer malignancy. BBA-Molecular Basis of Disease, 2011, 1812(4):514-519. Peng Jiang, Jingbao Li, Feng Han, Gaofei Duan, Xinzhi Lu, Yuchao Gu, Wengong Yu*. Antibiofilm activity of an exopolysaccharide from marine bacterium Vibrio sp. QY101. PLoS One, 2011, 6(4):e18514. Yuchao Gu, Wenyi Mi, Yuqing Ge, Haiyan Liu, Qiong Fan, Cuifang Han, Jing Yang, Feng Han, Xinzhi Lu, and Wengong Yu*. GlcNAcylation plays anrssentialrole in breast cancer metastasis. Cancer Res, 2010, 70(15): 6344-6351. Yuchao Gu, Junhua Zhang, Wenyi Mi, Jing Yang, Feng Han, Xinzhi Lu, Wengong Yu*. Silencing of GM3 synthase suppresses lung metastasis of murine breast cancer cells. Breast Cancer Res, 2008, 10(1): R1. Cuiping Ma, Xinzhilu, Chao Shi, Jingbao Li, Yuchao Gu, Yiming Ma, Yan Chu, Feng Han, Qianhong Gong, Wengong Yu*, Molecular cloning and characterization of a novel β-agarase, AgaB, from marine Pseudoalteromonas sp. CY24. J Biol Chem, 2007, 282(6): 3747-3754.