于广利 照片

于广利

教授

所属大学: 中国海洋大学

所属学院: 医药学院

邮箱:
glyu@ouc.edu.cn

个人主页:
https://smp.ouc.edu.cn/2019/0826/c17381a257549/page.htm

个人简介

教育背景: 1984.09 - 1988.06,青岛海洋大学化学系,化学,学士 1993.09 - 1996.06,青岛海洋大学海洋药物研究所,水产品贮藏与加工(食品化学),硕士 1998.09 - 2004.06,中国海洋大学医药学院,水产品加工及贮藏工程(海洋药物),博士 工作经历: 1988.07 - 1997.12,青岛海洋大学海洋药物研究所,助教、讲师 1997.12 - 2002.12,中国海洋大学海洋药物研究所,副教授 2002.12 - 至今,中国海洋大学医药学院,教授 获奖荣誉: 山东省有突出贡献中青年专家,山东省优秀科技工作者,荣获山东省五一劳动奖章,享受国务院政府特殊津贴专家。获国家技术发明一等奖(第 2 位)、国家海洋创新成果二等奖(第 1 位)、国家海洋科学技术二等奖(第 1 位)、教育部技术发明一等奖(第 3 位)、山东省高校科技成果一等奖(第 2)等科技奖励 9 项、山东省教学成果一等、二等和三等奖 5 项。 研究方向: 海洋生物多糖与寡糖及糖复合物的结构与活性研究 海洋糖库建设、糖芯片制备及糖与功能蛋白作用研究 内源性糖链(N,O - 糖链、GAGs 及糖脂)结构差异与疾病关系研究 海洋糖类创新药物及医用材

研究领域

海洋生物多糖与寡糖及糖复合物的结构与活性研究 海洋糖库建设、糖芯片制备及糖与功能蛋白作用研究 内源性糖链(N,O - 糖链、GAGs 及糖脂)结构差异与疾病关系研究 海洋糖类创新药物及医用材料的研究与开发

近期论文

1. Lin Pan, Tianyu Fu, Hao Cheng, Jianchen Mi, Qingsen Shang*, Guangli Yu*, Polysaccharide from edible alga Gloiopeltis furcata attenuates intestinal mucosal damage by therapeutically remodeling the interactions between gut microbiota and mucin O-glycans, Carbohydrate Polymers, 2022, 278: 118921. 2. Meimei Xing, Guoyun Li, Yang Liu, Luyao Yang, Youjiao Zhang, Yuruo Zhang, Jianhua Ding, Ming Lu*, Guangli Yu*, Gang Hu*, Fucoidan from Fucus vesiculosus prevents the loss ofdopaminergic neurons by alleviating mitochondrial dysunction through targeting ATP5F1a, Carbohydrate Polymers, 2022, 303: 120470. 3. Juan Yang†, Xianzhi Yang†, Wenfeng Pan, Mingshuo Wang, Yuxiong Lu, Jianeng Zhang, Ziqian Fang, Xiaomin Zhang, Yin Ji, Jin-Xin Bei, Jiajun Dong, Yi Wu, Chaoyun Pan, Guangli Yu*, Penghui Zhou* and Bo Li*, Fucoidan-Supplemented Diet Potentiates Immune Checkpoint Blockage by Enhancing Antitumor Immunity, Front. Cell Dev. Biol., 2021, 9: 733246. 4. Lin Pan, Xuze Ai, Tianyu Fu, Li Ren, Qingsen Shang*, Guoyun Li*, Guangli Yu*, In vitro fermentation of hyaluronan by human gut microbiota: Changes in microbiota community and potential degradation mechanism, Carbohydrate Polymers, 2021, 269: 118313. 5. Lin Pan#, Chao Cai#, Chanjuan Liu, Di Liu, Guoyun Li, Robert J Linhardt, Guangli Yu*, Recent Progress and Advanced Technology in Carbohydrate-Based Drug Development, Current Opinion in Biotechnology, 2021, 69: 191–198. 6. Xueliang Wang, Zimei Yang,Xu Xu,Hao Jiang*, Chao Cai*, Guangli Yu*, Odd-numbered agaro-oligosaccharides alleviate type 2 diabetes mellitus and related colonic microbiota dysbiosis in mice, Carbohydrate Polymers, 2020, 240: 116261. 7. Qingfeng Niu, Guoyun Li *, Chao Li, Qingyng Li, Jia Li, Chanjuan Liu, Lin Pan, Shijie Li, Chao Cai, Jiejie Hao, Guangli Yu, Two different fucosylated chondroitin sulfates: structural elucidation, stimulating hematopoiesis and immune-enhancing effects, Carbohydrate Polymers, 2020, 230: 115698. 8. Jun Li, Chao Cai*, Lihao Wang, Chendong Yang, Hao Jiang, Miaomiao Li, Ding Xu, Guoyun Li, Chunxia Li, and Guangli Yu*, Chemoenzymatic Synthesis of Heparan Sulfate Mimetic Glycopolymers and Their Interactions with the Receptor for Advanced Glycation End-Product, ACS Macro Lett. 2019, 8, 1570−1574. 9. Fan Su, Qiaoling Song, Chuanliang Zhang, Xiaohan Xu, Mengyuan Li, Dan Yao, Lijuan Wu, Xianjun Qu, Huashi Guan, Guangli Yu⁎, Jinbo Yang⁎, Chenyang Zhao*, A β-1,3/1,6-glucan from Durvillaea Antarctica inhibits tumor progression in vivo as an immune stimulator, Carbohydrate Polymers, 2019, 222: 114993. 10. X. Wang, X. Wang, H. Jiang, C. Cai, G. Li, J. Hao, G. Yu*, Marine polysaccharides attenuate metabolic syndrome by fermentation products and altering gut microbiota: an overview, Carbohydrate Polymers, 2018,195:601-612. 11. Y. Yang,X. Zhao, J. Li, H. Jiang, X. Shan, Y. Wang, W. Ma, J. Hao⁎, G. Yu*, A β-glucan from D. antarctica exerts immunomodulatory effects on RAW264.7 macrophages via Toll-like receptor 4, Carbohydrate Polymers, 2018,191:255-265. 12. Q. Li,C. Chao, Y. Chang, F. Zhang, RJ. Linhardt, C. Xue, G. Li*, G. Yu*, A novel structural fucosylated chondroitin sulfate from H. Mexicana and its effects on growth factors binding and anticoagulation, Carbohydrate Polymers, 2018, 181:1160-1168.