教育背景： 1983.09 - 1987.07，南开大学，化学，学士 1987.09 - 1990.07，南开大学元素有机化学研究所，有机化学，硕士 1998.09 - 2001.07，中国医学科学院 / 北京协和医科大学，药物化学，博士 工作经历： 1990.07 - 1998.08，华北制药集团，工程师 2002.03 - 2005.01，香港理工大学，研究助理 2005.01 - 至今，中国海洋大学医药学院，教授

天然产物结构改造及先导化合物发现 基于耐药靶点的计算机辅助药物设计、合成及活性研究

1. Dongdong Luo, Xiaochun Liu, Leilei Jiang, Zhikun Guo, Yan Lv, Xiaochen Tian,Xiaoyan Wang,Shuxiang Cui, Shengbiao Wan, Xianjun Qu*, Ximing Xu*, and Xiaoyang Li*. Rational Design, Synthesis and Biological Evaluation of Novel S1PR2 Antagonists for Reversing 5-FU-resistance in Colorectal Cancer. J. Med. Chem., 2022,in press. 2. Kairui Yue, Chen Xu, Zhihao Wang, Wandong Liu, Chenyu Liu, Ximing Xu, Yan Xing, Sheng Chen*, Xiaoyang Li*, Shengbiao Wan*.1,2-Isoselenazol-3(2H)-one derivatives as NDM-1 inhibitors displaying synergistic antimicrobial effects with meropenem on NDM-1 producing clinical isolates. Bioorg. Chem.,2022, 129,106153. 3.Dongdong Luo, Zhikun Guo, Xuecui Zhao, Lijuan Wu, Xiaochun Liu, Yuhang Zhang, Zirong Deng, Xianjun Qu, Shuxiang Cui*, Shengbiao Wan*, Novel 5-fluorouracil sensitizers for colorectal cancer therapy: design and synthesis of S1P receptor 2 (S1PR2) antagonists, Eur. J. Med. Chem., 2022, 227, 113923. 4. Iris L.K. Wong, Xing-kai Wang, Zhen Liu, Wenqin Sun, Fu-xing Li, Bao-chao Wang, Peng Li, Sheng-biao Wan, Larry M.C. Chow. Synthesis and evaluation of stereoisomers of methylated catechin and epigallocatechin derivatives on modulating P-glycoprotein-mediated multidrug resistance in cancers. Eur. J. Med. Chem., 2021, 226, 113795. 5. Dongdong Luo, Yuhang Zhang, Shuang Yang, Xiaochen Tian, Yan Lv, Zhikun Guo, Xiaochun Liu, Gaitian Han, Shuai Liu, Wenyu Wang, Shuxiang Cui, Xianjun Qu*, Shengbiao Wan*, Design, synthesis and biological evaluation of sphingosine-1-phosphate receptor 2antagonists as potent 5-FU-resistance reversal agents for the treatment of colorectal cancer, Eur. J. Med. Chem., 2021, 225, 113775. 6. Yuhang Zhang, Dongdong Luo, Shengbiao Wan*, Xianjun Qu*, S1PR2 inhibitors potently reverse 5-FUresistance by downregulating DPD expression in colorectal cancer, Pharmacol Res, 2020, 155, 104717. 7. Dongdong Luo, Yujiao Yi, Kai Peng, Tangrong Liu, Jiayu Yang, Shan Liu, Wanzhou Zhao, Xianjun Qu, Wengong Yu, Yuchao Gu*, Shengbiao Wan*. Oridonin derivatives as potential anticancer drug candidates triggering apoptosis through mitochondrial pathway in the liver cancer cells. Eur J Med Chem, 2019, 178, 365-379. 8. Chao Yang, Iris L.K. Wong, Kai Peng, Zhen Liu, Peng Wang, Tingfu Jiang, Tao Jiang, Larry M.C. Chow*, Sheng-Biao Wan*. Extending the structureactivity relationship study of marine natural ningalin B analogues as P-glycoprotein inhibitors. Eur J Med Chem, 2017, 125, 795−806. 9. Iris L. K. Wong, Bao-Chao Wang, Jian Yuan, Liang-Xing Duan, Zhen Liu, Tao Liu, Xue-Min Li, Xuesen Hu, Xiao-Yu Zhang, Tao Jiang, Sheng-Biao Wan*, and Larry M. C. Chow*. Potent and Nontoxic Chemosensitizer of P-Glycoprotein-mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives. J Med Chem, 2015, 58, 4529−4549. 10. Jin Wen Bin, Wong Iris L. K., Hu Xue Shen, Zhang Xiao Yu, Li Fu Xing, Jiang Tao, Larry M. C. Chow* and Wan Sheng Biao*. Structure-activity relationship study of permethylningalin B analogues as P-glycoprotein chemosensitizers. J Med Chem, 2013, 56, 9057-9070.