秦冲 照片

秦冲

教授

所属大学: 中国海洋大学

所属学院: 青岛海洋生物医药研究院

邮箱:
qc@ouc.edu.cn

个人主页:
https://qdmbri.com/c_70/1273.html

个人简介

工作经历 担任中国海洋大学医药学院教授、博士生导师,在现代海洋药物研发室开展工作。 担任青岛海洋生物医药研究院副院长,参与研究院的管理和科研工作。 荣誉奖项 2014 年,获北京大学学生五四奖章。 2019 年,获北京市自然科学奖一等奖。 2021 年,主讲的《高等药物化学》研究生课程获山东省研究生教育优质课程。 2022 年,主讲的《高等药物化学》研究生课程获教育部 “拓金计划” 示范课程 。

研究领域

1. 基于靶向蛋白降解(PROTACs)策略的小分子先导化合物发现和新药发现 2. 去势抵抗性前列腺癌治疗药物研究 3. 海洋天然活性物质的结构多样性修饰及成药性优化

近期论文

1. Siqi Zhang+, Xiaolei Meng+, Sai Zhang+, Baohu Li, WencongJin, Chengwei Zhang, Zhaojuan Liu, Xiaolin Hu, Ling Ge, Zhonghao Yu, Zhuoyue Li, Shumin Ma, Xiao Wang, Liming Li, Chong Qin*. Design, Synthesis and Biological Evaluation of Androgen Receptor (AR) Antagonist-Heat Shock Protein 90 (Hsp90) Inhibitor Conjugates for Targeted Therapy of Castration-Resistant Prostate Cancer. J. Med. Chem.2023, doi: 10.1021/acs.jmedchem.2c01970. (IF: 8.039) 2. Liming Li+*, Heping Zheng+, Xuepei Ma, Jie Bai, Shumin Ma, Zhuoyue Li, Chong Qin*. Inhibition of Astrocytic Carbohydrate Sulfotransferase 15 Promotes Nerve Repair After Spinal Cord Injury via Mitigation of CSPG Mediated Axonal Inhibition. Cell. Mol. Neurobiol.2023, doi: 10.1007/s10571-023-01333-9. (IF: 4.231) 3. Qiang Wang, Baohu Li, Wenkai Zhang, Zhuoyue Li, Bo Jiang*, Sichuan Hou*, Shumin Ma*, Chong Qin*, Lethal Activity of BRD4 PROTAC Degrader QCA570 Against Bladder Cancer Cells. Front. Chem.2023, doi.org/10.3389/fchem.2023.1121724. (IF: 5.545) 4. Ruxuan Wang, Tengjiang Zhong, QiongBian, Sai Zhang, Xiaolu Ma, Liming Li, Yihua Xu, Yueting Gu, Anran Yuan, Weitong Hu, Chong Qin*,Jianqing Gao*, PROTAC Degraders of Androgen Receptor-Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration. Small Methods. 2023, 7, 2201293. (IF: 14.188) 5. Chong Qin and Ning Jiao*, Iron-Facilitated Direct Oxidative C−H Transformation of Allylarenes or Alkenes to Alkenyl Nitriles. J. Am. Chem. Soc.2010, 132, 15893-15895; 6. Chong Qin, Wang Zhou, Feng Chen, Yang Ou and Ning Jiao*, Iron-catalyzed C-H and C-C Bond Cleavage: A Direct Approach to Amides from Simple Hydrocarbon Molecules, Angew. Chem. Int. Ed. 2011, 50, 12595-12599; 7. Chong Qin, Tao Shen, Conghui Tang and Ning Jiao*, FeCl2-promoted Unactivated C-C Bond Cleavage of Alkylarenes and Polystyrene: Direct Synthesis of Versatile Arylamines, Angew. Chem. Int. Ed.2012, 51, 6971-6975; 8. Chong Qin, Peng Feng, Yang Ou, Tao Shen, Teng Wang and Ning Jiao*, Highly Selective Csp2-Csp Bond Cleavage: The Nitrogenation of Alkynes to Amides.Angew. Chem. Int. Ed. 2013, 52, 7850-7854; 9. Chong Qin,+YijinSu,+Xiaodong Shi and Ning Jiao*, Splitting a Substrate into Three Parts: Gold-Catalyzed Nitrogenation of Alkynes by C-C and C≡C Bond Cleavage. Angew. Chem. Int. Ed. 2016, 55, 350-354; 10. Chong Qin,+Yang Hu,+ Bing Zhou,+... Shaomeng Wang*, Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J. Med. Chem.2018, 61, 6685–6704.