教育背景： 1994.09 - 1999.06，山西医科大学，儿科学，学士 2000.09 - 2003.07，第二军医大学 / 青岛大学，生理学，硕士 2003.09 - 2006.07，第二军医大学，药理学，博士 工作经历： 2006.07 - 2012.12，中国海洋大学医药学院，讲师 2011.07 - 2012.08，密歇根大学分子细胞发育生物学系，访问学者 2013.01 - 至今，中国海洋大学医药学院，副教授

肿瘤缺氧微环境关键信号通路 缺氧相关红细胞疾病的生物标志物及治疗靶标的发现 斑马鱼疾病模型构建及药物筛选

代表性论文 1. Yue Y, Tang Y, Huang H, Zheng D, Liu C, Zhang H, Liu Y, Li Y, Sun X, Lu L*. VBP1 negatively regulates CHIP and selectively inhibits the activity of hypoxia-inducible factor (HIF)-1α but not HIF-2α. J Biol Chem. 2023; 299(6): 104829. 2. Dou X, Chen Z, Liu Y, Li Y, Ye J, Lu L*. Zebrafish mutants in egln1 display a hypoxic response and develop polycythemia. Life Sci. 2024; 344:122564. 3. Yang Y, Qin L, Lu X, Lu L*, Mao W*. A pyruvylated and sulfated galactan from the green alga Dictyosphaeria cavernosa: Structure, anticoagulant property and inhibitory effect on zebrafish thrombosis. Carbohydr Polym. 2024; 324:121492. 4. Zhang P, Sun C, Yin T, Guo J, Chong D, Tang Y, Liu Y, Li Y, Gu Y*, Lu L*. ESF1 positively regulates MDM2 and promotes tumorigenesis. Int J Biol Macromol. 2024;276(Pt 1):133652. 5. Chen JY, Tan X, Wang ZH, Liu YZ, Zhou JF, Rong XZ, Lu L*, Li Y*. The ribosome biogenesis protein Esf1 is essential for pharyngeal cartilage formation in zebrafish. FEBS J. 2018 ;285(18):3464-3484. 6.Chen S, Liu Y, Rong X, Li Y, Zhou J, Lu L*. Neuroprotective Role of the PI3 Kinase/Akt Signaling Pathway in Zebrafish. Front Endocrinol. 2017; 8:21 7. Mu X, Qi W, Liu Y, Zhou J, Li Y, Rong X, Lu L*. IGF-II-mediated downregulation of peroxisome proliferator-activated receptor-γ coactivator-1α in myoblast cells involves PI3K/Akt/FoxO1 signaling pathway. Mol Cell Biochem. 2017;432(1-2):199-208 8. Gao S#, Lu L#, Bai Y, Zhang P, Song W, Duan C*. Structural and functional analysis of amphioxus HIFα reveals ancient features of the HIFα family. FASEB J. 2014; 28(4):1880-90 9.Jiao S, Ren H, Li Y, Zhou J, Duan C, Lu L*. Differential regulation of IGF-I and IGF-II gene expression in skeletal muscle cells. Mol Cell Biochem. 2013; 373(1-2 ):107-13. 10.Zhang C#, Lu L#, Li Y, Wang X, Zhou J, Liu Y, Fu P, Gallicchio MA, Bach LA, Duan C*. IGF binding protein-6 expression in vascular endothelial cells is induced by hypoxia and plays a negative role in tumor angiogenesis. Int J Cancer. 2012; 130(9):2003-12