教育经历 2005 - 2009 年，山东师范大学制药工程系，理学学士 2009 - 2014 年，中科院上海药物研究所药物化学专业，博士 工作经历 2014.06 - 2019.08，美国得克萨斯大学医学分部药理与毒理系，博士后 2019.9 至今，中国海洋大学进化所 & 医药学院双聘，教授

分子靶向的海洋药物先导物发现、海洋天然产物全合成及结构修饰、活性评价及机制研究。

1) Maimaitiming M.; Lv L.; Zhang X.; Xia S.; Li X.; Wang P. *; Liu Z. *; Wang C-Y*. Semi- Synthesis and Biological Evaluation of 25(R)-26-Acetoxy-3β,5α-Dihydroxycholest-6-One. Marine Drugs. 2023; 21(3):191. 2) Li, H.#; Ouyang, S.#; Zhang, Y.; Peng, K.; Fang, W.; Liu, Z.*; Wang, C.*; Zhang, X.*; Wang, Y.* Structural Optimization of Imidazo[1, 2-a]pyridine Derivatives for the Treatment of Gastric Cancer via STAT3 Signaling Pathway. Eur. J. Med. Chem., 2022, 244:114858. 3) Li, R.#; Zhou, Y.#; Zhang, X.; Yang, L.; Liu, J.; Wightman, S. M.; Lv, L.; Liu, Z.*; Wang, C.*; Zhao, C*. Identification of Marine Natural Product Pretrichodermamide B as a STAT3 Inhibitor for Efficient Anticancer Therapy. Mar. Life Sci. Technol., 2022, 5, 94-101. 4) Li, H.#; Maimaitiming, M.#; Zhou, Y.; Li, H.; Wang, P.; Liu, Y.; Schaberle, T. F.; Liu, Z.*; Wang, C.* Discovery of Marine Natural Products as Promising Antibiotics against Pseudomonas aeruginosa. Mar. Drugs, 2022, 20, 192. 5) Liu, Z.#; Li, Y.#; Chen, H.; Lai, H. T.; Wang, P.; Wu, S. Y.; Wold, E. A.; Leonard, P. G.; Joseph, S.; Hu, H.; Chiang, C. M.; Brasier, A. R.*; Tian, B.*; Zhou, J.* Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site. J. Med. Chem.,2022, 65,3, 2388-2408. 6) Liu, Z.*, Wang, P., Wold, E.A., Song, Q., Zhao, C., Wang, C.* and Zhou, J.* Small-Molecule Inhibitors Targeting the Canonical WNT Signaling Pathway for the Treatment of Cancer. J. Med. Chem.,2021, 64 (8), 4257-4288. 7) Liu, Z.; Chen, H.; Wang, P.; Li, Y.; Wold, E. A.; Leonard, P. G.; Joseph, S.; Brasier, A. R.; Tian, B.; Zhou, J. Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation. J. Med. Chem., 2020, 63, 5242-5256. 8) Niu, Q.#; Liu, Z.#; Alamer, E.; Fan, X.; Chen, H.; Endsley, J.; Gelman, B. B.; Tian, B.; Kim, J. H.; Michael, N. L.; Robb, M. L.; Ananworanich, J.; Zhou, J.; Hu, H. Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV. J. Clin. Invest. 2019, 129, 3361-3373. (#co-first author) 9) Liu, Z.; Tian, B.; Chen, H.; Wang, P.; Brasier, A. R.; Zhou, J. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur. J. Med. Chem. 2018, 151, 450-461. 10) Tian, B.#; Liu, Z.#; Yang, J.; Sun, H.; Zhao, Y.; Wakamiya, M.; Chen, H.; Rytting, E.; Zhou, J.; Brasier, A. R. Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation. Cell Rep. 2018, 23, 1138-1151. (#co-first author)