1983年本科毕业于兰州大学数力系数学专业，1997年兰州大学获理学博士学位；1998年1月- 1999年1月在新加坡国立大学生物信息学中心 (BIC, NUS) 博士后，1999年2月- 2000年1月在新加坡国立大学生物信息学中心 (BIC, NUS) 工作 (Research Fellow)，2000年2月- 2001年10月在新加坡分子与细胞生物学研究院 (Institute of Molecular & Cell Biology) 工作 (Research Fellow)，2001年11月- 2002年8月在新加坡基因组研究所 (Genome Institute of Singapore) 工作 (Research Scientist)；2002年8月- 2007年6月任北京师范大学生命科学学院生物信息学副教授，2007年7月至今任北京师范大学生命科学学院生物信息学教授。

植物与微生物基因组分析：通过建立分析平台，对基因组／转录组数据进行组装、注释以及基因功能与进化分析，并建立起对应的组学数据库供相关研究者使用（主要与中国农科院黄三文研究员合作） 大肠杆菌实验进化研究：利用全群体全基因组测序(whole-genome whole-population sequencing)方法研究在特定条件下大肠杆菌群体适应过程中基因组的变化动态（与生态所张大勇教授合作） 基因组进化：基于特定进化生物学问题，开发、改进和应用计算方法，对全基因组序列进行比较分析，试图理解基因组水平上物种或者群体的进化历史

Bowen Zhang, Linlin Xu, Nan Li, Pengcheng Yan, Xinhua Jiang, Keith E Woeste Lin Kui, Susanne S Renner, Dayong Zhang, Weining Bai(2019). Phylogenomics reveals an ancient hybrid origin of the Persian walnut. Molecular biology and evolution, 2019, 4 [Online Text] Yu-Ting Lai, Carol K. L. Yeung, Kevin E. Omland, Er-Li Pang, Yu Hao, Ben-Yang Liao, Hui-Fen Cao, Bo-Wen Zhang, Chia-Fen Yeh, Chih-Ming Hung, Hsin-Yi Hung, Ming-Yu Yang, Wei Liang, Yu-Cheng Hsu, Cheng-Te Yao, Lu Dongd, Lin Kui, Shou-Hsien L(2019). Standing genetic variation as the predominant source for adaptation of a songbird. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116(6) :2152-2157. [Online Text] Xiao-Lin Chu, Bo-Wen Zhang, Quan-Guo Zhang, Bi-Ru Zhu, Lin Kui, Da-Yong Zhang(2018). Temperature responses of mutation rate and mutational spectrum in an Escherichia coli strain and the correlation with metabolic rate. BMC EVOLUTIONARY BIOLOGY, 2018, 18 :126. [Online Text] Song Hongtao, Lin Kui, Hu Jinglu, Pang Erli(2018). An Updated Functional Annotation of Protein-Coding Genes in the Cucumber Genome. Frontiers in Plant Science, 2018, 9 :325. [Online Text] Jia Song, Sisi Zheng, Nhung Nguyen, Youjun Wang, Yubin Zhou, Kui Lin(2017). Integrated pipeline for inferring the evolutionary history of a gene family embedded in the species tree: a case study on the STIMATE gene family BMC Bioinformatics, 2017 , 18 (1) :439 [Online Text] Pang, E., Wu, X., & Lin, K. (2016). Different evolutionary patterns of snps between domains and unassigned regions in human protein-coding sequences. Molecular Genetics & Genomics, 291(3), 1127. [Online Text] APAPang, E., Hao, Y., Sun, Y., & Lin, K.(2016). Differential variation patterns between hubs and bottlenecks in human protein-protein interaction networks. Bmc Evolutionary Biology16(1), 260. [Online Text] Cao, H., Pang, E., & Lin, K.(2016). Hierarchical Map of Orthologous Genomic Regions Reconstructed from Two Closely Related Genomes: Cucumber Case Study. The Plant Genome, 9(3). [Online Text] Zhang Y C, Lin K.(2015). Phylogeny Inference of Closely Related Bacterial Genomes: Combining the Features of Both Overlapping Genes and Collinear Genomic Regions[J]. Evolutionary Bioinformatics , 2015, 11(Suppl 2): 1. [Online Text] Zhang Y C, Zhang Y, Zhu B R, et al. Genome sequences of two closely related strains of Escherichia coli K-12 GM4792[J]. Standards in Genomic Sciences , 2015, 10(1): 1-9. [Online Text] Liu, T., Lin, K.(2015). The distribution pattern of genetic variation in the transcript isoforms of the alternatively spliced protein-coding genes in the human genome. Mol Biosystems. 11(5):1378–1388. [Online Text] Lin, T., Zhu, G., Zhang, J., Xu, X., Yu, Q., Zheng, Z.,…,Zhang, Y.C., Lin, K.,…, Huang, S. (2014). Genomic analyses provide insights into the history of tomato breeding. Nature Genetics, 46(11), 1220–1226. doi:10.1038/ng.3117 Lin, K., Limpens, E., Zhang, Z.H, Ivanov, S., Saunders, DGO., Mu, D.S., Pang, E.L., Cao, H.F., Cha, H.H., Lin, T., Zhou, Q., Shang, Y., Li, Y., Sharma, T., Velzen, R.V., Ruijter, N., Aanen, D.K., Win, J., Kamoun, S., Bisseling, T., Geurts, R., Huang, S.W. (2014) Single Nucleus Genome Sequencing Reveals High Similarity among Nuclei of an Endomycorrhizal Fungus. PLoS Genet 10(1): e1004078. doi:10.1371/journal.pgen.1004078 Luo, Y.Q., Battistuzzi, F., Lin, K. (2013) Evolutionary Dynamics of Overlapped Genes in Salmonella. PLOS ONE, doi:10.1371/journal.pone.0081016 Dong, W.P., Xu, C., Cheng, T., Lin, K. and Zhou, S.L. (2013) Sequencing Angiosperm Plastid Genomes Made Easy: A Complete Set of Universal Primers and a Case Study on the Phylogeny of Saxifragales. Genome Biology and Evolution, doi:10.1093/gbe/evt063. Wu, X.M., Pang, E.L., Lin, K. and Pei, Z.M. (2013) Improving the Measurement of Semantic Similarity between Gene Ontology Terms and Gene Products: Insights from an Edge- and IC-Based Hybrid Method. PLOS ONE, doi:10.1371/journal.pone.0066745. He, F.L., Zhang, D.Y., Lin, K. (2012) Coexistence of nearly neutral species. JOURNAL OF PLANT ECOLOGY, doi:10.1093/jpe/rtr040. Zhang, D.Y., Zhang, B.Y., Lin, K.,..., O.A. (2012) Demographic trade-offs determine species abundance and diversity. JOURNAL OF PLANT ECOLOGY, doi: 10.1093/jpe/rtr039. Guo, S.G., Zhang, J.G., Sun, H.H.,..., Tan, T., Pang E.L., Lin K.,..., Fei, Z.J. and Xu, Y. (2012) The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions. Nature Genetics, doi:10.1038/ng.2470. Zhang, Y. and Lin, K. (2012) A phylogenomic analysis of Escherichia coli / Shigella group: implications of genomic features associated with pathogenicity and ecological adaptation. BMC Evolutionary Biology, doi:10.1186/1471-2148-12-174. Pang, E.L., Tan, T. and Lin, K. (2012) Promiscuous domains: facilitating stability of the yeast protein-protein interaction network. Mol. BioSyst., doi:10.1039/C1MB05364G. Li, Z., Zhang, Z.H., Yan, P.C., Huang, S.W., Fei, Z.j., and Lin, K. (2011) RNA-Seq improves annotation of protein-coding genes in the cucumber genome. BMC Genomics, doi: 10.1186/1471-2164-12-540 Pang, E.L. and Lin, K. (2010) Yeast protein–protein interaction binding sites: prediction from the motif–motif, motif–domain and domain–domain levels. Molecular BioSystems, doi: 10.1039/C0MB00038H. Huang, S.W., Li, R.Q., Zhang, Z.H., Li, L., Gu, X.F., Fan, W., Lucas, W.J., Wang, X.W., Xie, B.Y., Ni, P.X., Ren, Y.Y., Zhu, H.M., Li, J., Lin, K., Jin, W.W., Fei, Z.J., ... Kristiansen, K., Zheng, H.C., Li, S.C., Zhang, X.Q., Yang, H.M., Wang, J., Sun, R.F., Zhang, B.X., Jiang, S.Z., Wang, J., Du, Y.C. and Li, S.G. (2009) The genome of the cucumber, Cucumis sativus L. Nature Genetics, 41:1275-1281. Wu, X.M., Guo, J., Zhang, D.Y. and Lin, K. (2009) The properties of hub proteins in a yeast-aggregated cell cycle network and its phase sub-networks. Proteomics, 9:4812-4824. Fu, C. and Lin, K. (2009) Computational Analysis of miRNA and Target mRNA Interactions: Combined Effects of The Quantity and Quality of Their Binding Sites. Progress in Biochemistry and Biophysics, 36(5):608-615. Lin, K., Zhang, D.Y. and He, F. (2009) Demographic trade-offs in a neutral model explains death rate-abundance rank relationship. Ecology, 90(1):31-38. Zhou, H.J. and Lin, K. (2008) Excess of microRNAs in large and very 5' biased introns. Biochemical and Biophysical Research Communications, 368:709-715. Guo, J., Wu, X.M., Zhang, D.Y. and Lin, K. (2008) Genome-wide inference of protein interaction sites: lessons from the yeast high-quality negative protein–protein interaction dataset. Nucleic Acids Research, 36(6):2002-2011. Luo, Y.Q., Fu, C., Zhang, D.Y. and Lin, K. (2007) BPhyOG: An interactive server for genome-wide inference of bacterial phylogenies based on overlapping genes. BMC Bioinformatics, 8:266. Wu, X.M., Zhu, L., Guo, J., Fu, C., Zhou, H.J., Dong, D., Li, Z.B., Zhang, D.Y. and Lin, K. (2006) SPIDer: Saccharomyces protein-protein interaction database. BMC Bioinformatics, 7:S16. Luo, Y.Q., Fu, C., Zhang, D.Y. and Lin, K. (2006) Overlapping genes as rare genomic markers: the γ-Proteobacteria phylogeny as a case study. Trends in Genetics, 22(11):593-596. Lin, K., Zhu, L. and Zhang, D.Y. (2006) An initial strategy for comparing proteins at the domain architecture level. Bioinformatics, 22(17):2081-2086. Wu, X.M., Zhu, L., Guo, J., Zhang,D.Y. and Lin, K. (2006) Prediction of yeast protein–protein interaction network: insights from the Gene Ontology and annotations. Nucleic Acids Research, 34(7):2137-2150. He, Y.W., Xu, M., Lin, K., Ng, Y.J., Wen, C.M., Wang, L.H., Liu, Z.D., Zhang, H.B., Dong, Y.H., Dow, J.M. and Zhang, L.H. (2006) Genome scale analysis of diffusible signal factor regulon in Xanthomonas campestris pv. campestris: identification of novel cell-cell communication-dependent genes and functions. Molecular Microbiology, 59(2):610-22. Sun, Q.L., Zhou, H.J., Lin, K. (2005) The Evolutionary Relationship of the Domain Architectures in the RhoGEF-containing Proteins. Genomics, Proteomics & Bioinformatics, 3:94-106. Lin, K. and Zhang, D.Y. (2005) The excess of 5' introns in eukaryotic genomes. Nucleic Acids Research, 33:6522-6527. Peng, X., Karuturi, R.K.M., Miller, L.D., Lin, K., Jia, Y.H., Kondu, P., Wang, L., Wong, L.S., Liu, E.T., Balasubramanian, M.K. and Liu, J.H. (2005) Identification of Cell Cycle-regulated Genes in Fission Yeast. Molecular Biology Cell, 16:1026-1042. Zhang, D.Y., Lin, K. and Hanski, I. (2004) Coexistence of cryptic species. Ecology Letters, 7:165-169. Niu, D.K., Lin, K. and Zhang, D.Y. (2003) Strand compositional asymmetries of nuclear DNA in eukaryotes. Journal of Molecular Evolution, 57:325-334. Ng, S.K., Zhang, Z., Tan, S.H. and Lin, K. (2003) InterDom: a database of putative interacting protein domains for validating predicted protein interactions and complexes. Nucleic Acids Research, 31(1):251-254. Lin, K., Kuang, Y.Y., Joseph, J.S. and Kolatkar, P.R. (2002) Conserved codon usage composition of ribosomal protein-coding genes in Escherichia coli, Mycobaterium tuberculosis and Saccharomyces cerevisiae: lessons from supervised machine learning in functional genomics. Nucleic Acids Research, 30(11):2599-2607. Epstein, R.J., Lin, K. and Tan, T.W. (2000) A functional significance for codon third bases. Gene, 245(2):291-298. Kangueane, P., Sakharkar, M.K., Lim, K.S., Han H., Lin K., Chee, R.E. and Kolatkar, P.R. (2000) Knowledge based grouping of modeled HLA peptide complexes. Human Immunology, 61:460-466. Lin, K., Ting, A., Wang, J.R. and Wong, L. (1998) Hunting TPR domain using Kleisli. Proceedings of 9th Workshop on Genome Informatics, Tokyo, Japan, 173-182. Zhang, D.Y. and Lin, K. (1997) The effects of competitive asymmetry on the rate of competitive displacement: how robust is Hubbell’s community drift model? Journal of Theoretical Biology, 188:361-367.