研究领域
生物传感器（Biosensors）、生物电分析化学（Bio-electroanalysis）、纳米生物技术（Nanobiotechnology）
1. 基于新型纳米材料分析信号放大的疾病标志物高灵敏电化学生物传感
2. 生物分子的可视化分析
3. DNA自组装及DNA纳米结构在生物分析中的应用
近期论文
Cuiyun Yang, Kai Shi, Baoting Dou, Yun Xiang,* Yaqin Chai, Ruo Yuan, In situ DNA-templated synthesis of silver nanoclusters for ultrasensitive and label-free electrochemical detection of microRNA, ACS Applied Materials & Interfaces, 2015, DOI: 10.1021/am506933r.
Ying Chen, Yun Xiang,* Ruo Yuan,* Yaqin Chai, A restriction enzyme-powered autonomous DNA walking machine: its application for a highly sensitive electrochemiluminescence assay of DNA, Nanoscale, 2015, 7, 981–986.
Yunying Xu, Wenjiao Zhou, Ming Zhou, Yun Xiang,* Ruo Yuan, Yaqin Chai, Toehold strand displacement-driven assembly of G-quadruplex DNA for enzyme-free and non-label sensitive fluorescent detection of thrombin, Biosensors & Bioelectronics, 2015, 64, 306–310.
Xue Gong, Wenjiao Zhou, Yaqin Chai, Yun Xiang,* Ruo Yuan, Terminal protection of small molecule-linked ssDNA for label-free and highly sensitive colorimetric detection of folate receptor biomarkers, RSC Advances, 2015, 5, 6100–6105.
Cuiyun Yang, Baoting Dou, Kai Shi, Yaqin Chai, Yun Xiang,* Ruo Yuan, Multiplexed and amplified electronic sensor for the detection of microRNAs from cancer cells, Analytical Chemistry, 2014, 86, 11913–11918.
Wenjiao Zhou, Xue Gong, Yun Xiang,* Ruo Yuan, Yaqin Chai, Target-triggered quadratic amplification for label-free and sensitive visual detection of cytokines based on hairpin aptamer DNAzyme probes, Analytical Chemistry, 2014, 86, 953–958.
Ying Chen, Mengli Yang, Yun Xiang,* Ruo Yuan,* Yaqin Chai, Binding-induced autonomous disassembly of aptamer-DNAzyme supersandwich nanostructures for sensitive electrochemiluminescence turn-on detection of Ochratoxin A, Nanoscale, 2014, 6, 1099–1104.
Xue Gong, Jinfu Li, Wenjiao Zhou, Yun Xiang,* Ruo Yuan, Yaqin Chai, Target recycling amplification for label-free and sensitive colorimetric detection of adenosine triphosphate based on un-modified aptamers and DNAzymes, Analytica Chimica Acta, 2014, 828, 80–84.
Yulian Wei, Wenjiao Zhou, Yunying Xu, Yun Xiang,* Ruo Yuan and Yaqin Chai, Graphene nanosensor for highly sensitive fluorescence turn-on detection of Hg2+ based on target recycling amplification, RSC Advances, 2014, 4, 39082–39086.
Yunying Xu, Bingying Jiang, Jiaqing Xie, Yun Xiang,* RuoYuan, Yaqin Chai, Terminal protection of small molecule-linked ssDNA for label-free and sensitive fluorescent detection of folate receptor, Talanta, 2014, 128, 237–241.
Cuiyun Yang, Qiong Wang, Yun Xiang,* Ruo Yuan, Yaqin Chai, Target-induced strand release and thionine-decorated gold nanoparticle amplification labels for sensitive electrochemical aptamer-based sensing of small molecules, Sensors and Actuators B, 2014, 197, 149–154.
Mengli Yang, Bingying Jiang, Jiaqing Xie, Yun Xiang,* RuoYuan, Yaqin Chai, Electrochemiluminescence recovery-based aptasensor for sensitive Ochratoxin A detection via exonuclease-catalyzed target recycling amplification, Talanta, 2014, 125, 45–50.
Mengli Yang, Ying Chen, Yun Xiang,* Ruo Yuan, Yaqin Chai, Target-induced structure switching of DNA for label-free and ultrasensitive electrochemiluminescent detection of proteins, Chemical Communications, 2014, 50, 3211–3213.
Qiong Wang, Cuiyun Yang, Yun Xiang,* RuoYuan, YaqinChai, Dual amplified and ultrasensitive electrochemical detection of mutant DNA biomarkers based on nuclease-assisted target recycling and rolling circle amplifications, Biosensors & Bioelectronics, 2014, 55, 266–271.
Wenjiao Zhou, Xue Gong, Yun Xiang,* Ruo Yuan, Yaqin Chai, Quadratic recycling amplification for label-free and sensitive visual detection of HIV DNA, Biosensors & Bioelectronics, 2014, 55, 220–224.
Wenjiao Zhou, Jiao Su, Yaqin Chai, Ruo Yuan, Yun Xiang,* Naked eye detection of trace cancer biomarkers based on biobarcode and enzyme-assisted DNA recycling hybrid amplifications, Biosensors & Bioelectronics, 2014, 53, 494–498.
Jin Xu, Qiong Wang, Yun Xiang,* Ruo Yuan, Yaqin Chai, Cascade signal amplification for ultrasensitive electrochemical DNA detection, Analyst, 2014, 139, 128–132.
Yunying Xu, Jin Xu, Yun Xiang,* Ruo Yuan, Yaqin Chai, Target-induced structure switching of hairpin aptamers for label-free and sensitive fluorescent detection of ATP via exonuclease-catalyzed target recycling amplification, Biosensors & Bioelectronics, 2014, 51, 293–296.
Jiao Su, Wenjiao Zhou, Yun Xiang,* Ruo Yuan, Yaqin Chai, Target-induced charge reduction of aptamers for visual detection of lysozyme based on positively charged gold nanoparticles, Chemical Communications, 2013, 49, 7659–7661.
Mengli Yang, Ying Chen, Yun Xiang,* Ruo Yuan, Yaqin Chai, In situ energy transfer quenching of quantum dot electrochemiluminescence for sensitive detection of cancer biomarkers, Biosensors & Bioelectronics, 2013, 50, 393–398.
Ying Chen, Mengli Yang, Yun Xiang,* Ruo Yuan,* Yaqin Chai, Ligase chain reaction amplification for sensitive electrochemiluminescent detection of single nucleotide polymorphisms, Analytica Chimica Acta, 2013, 796, 1–6.
Qiong Wang, Bingying Jiang, Jiaqing Xie, Yun Xiang,* Ruo Yuan, Yaqin Chai, Coupling of background reduction with rolling circle amplification for highly sensitive protein detection via terminal protection of small molecule-linked DNA, Analyst, 2013, 138, 5751–5756.
Ying Chen, Qiong Wang, Jin Xu, Yun Xiang,* Ruo Yuan,* Yaqin Chai, A new hybrid signal amplification strategy for ultrasensitive electrochemical detection of DNA based on enzyme-assisted target recycling and DNA supersandwich assemblies, Chemical Communications, 2013, 49, 2052–2054.
Jiao Su, Jin Xu, Ying Chen, Yun Xiang,* Ruo Yuan, Yaqin Chai, Sensitive detection of copper(II) by a commercial glucometer using click chemistry, Biosensors & Bioelectronics, 2013, 45,219–222.
Qiong Wang, Bingying Jiang, Jin Xu, Jiaqin Xie, Yun Xiang,* Ruo Yuan, Yaqin Chai, Amplified terminal protection assay of small molecule/protein interactions via a highly characteristic solid-state Ag/AgCl process, Biosensors & Bioelectronics, 2013, 43, 19–24.