Education 2014 - 2018 Ph.D. The Chinese University of Hong Kong 2010 - 2014 B.Sc. Nankai University Position Since 2022 Assistant Professor (Vice-Chancellor Early Career Professorship Scheme), The Chinese University of Hong Kong 2019 - 2022 Postdoctoral Scholar, University of Chicago 2018 - 2019 Research Associate, The Chinese University of Hong Kong Honors & Awards 2021 Suzuki Postdoctoral Fellowship Award 2019 Ministry of Education Higher Education Outstanding Scientific Research Output Awards Second-class Award in Natural Sciences 2014-2018 Hong Kong PhD Fellowship

The Lyu group focuses on the development of new reagents, catalytic systems and synthetic methodologies for the application in the late-stage functionalization of complicated bioactive molecules and streamline synthesis of functional materials and drug molecules. Initial research directions:​ 1. Methodologies involving transition metal catalysis and photo-/electro-catalysis 2. Design, preparation and property study of new organoboron compounds, including borylation reagents and boron-containing functional materials 3. Application of the newly developed organoboron reagents in the synthesis and late-stage functionalization of drug molecules

Copper catalyzed C−B(sp3) bond formation through the intermediacy of Cu−B(sp3) complex. Ye, Z.;† Kwok, C. Y.;† Lam, S. L.; Wu, L.;* and Lyu, H.* J. Am. Chem. Soc. 2025. doi.org/10.1021/jacs.5c00974. Electrochemical Borylation of C−C and C−Het Bonds. Cheung, T. L. and Lyu, H*. ChemElectroChem. 2025, doi.org/10.1002/celc.202400560 Functionalization of Boranes through Thiol/Oxygen Catalysis. Tao, H. and Lyu, H*. Chin. J. Chem. 2024, doi.org/10.1002/cjoc.202400494. Stereoselective Unsymmetrical 1,1-Diborylation of Alkynes with a Neutral sp2-sp3 Diboron Reagent. Lou, X.;† Lin, J.;† Kwok, C. Y.; Lyu, H.* Angew. Chem. Int. Ed. 2023, e202312633. Lyu, H.; Tugwell, T. H.; Chen, Z.; Kukier, G. A.; Turlik, A.; Wu, Y.; Houk, K. N.; Liu, P.; Dong, G. Modular Synthesis of 1,2-Azaborines via Ring-opening BN-isostere Benzannulation” Nat. Chem. 2023, https://doi.org/10.1038/s41557-023-01343-6. Lyu, H.; Kevlishvili, I.; Xuan, Y.; Liu, P.; Dong, G. Boron Insertion into Alkyl Ether Bonds via Zinc/Nickel Tandem Catalysis. Science 2021, 372, 175-182. Au, Y. K.;† Lyu, H.;† Quan, Y.; Xie, Z. Copper-Catalyzed Electrochemical Selective B–H Oxygenation of o-Carboranes at Room Temperature. J. Am. Chem. Soc. 2020, 142, 6940–6945. (†co-first author) Lyu, H.; Zhang, J.; Yang, J.; Quan, Y.; Xie, Z. Catalytic Regioselective Cage B(8)–H Arylation of o-Carboranes via “Cage-Walking” Strategy. J. Am. Chem. Soc. 2019, 141, 4219-4224. Lyu, H.; Quan, Y.; Xie, Z. Transition Metal Catalyzed Direct Amination of Cage B(4)−H Bond in o-Carboranes: Synthesis of Tertiary, Secondary and Primary o-Carboranyl Amines. J. Am. Chem. Soc. 2016, 138, 12727-12730. Lyu, H.; Quan, Y.; Xie, Z. Rhodium-Catalyzed Regioselective Hydroxylation of Cage B−H Bonds of o-Carboranes with O2 or Air. Angew. Chem., Int. Ed. 2016, 55, 11840-11844. Lyu, H.; Quan, Y.; Xie, Z. Palladium-Catalyzed Direct Dialkenylation of Cage B-H Bonds in o-Carboranes through Cross-Coupling Reactions. Angew. Chem., Int. Ed. 2015, 54, 10623-10626. Lyu, H.; Quan, Y.; Xie, Z. Rhodium Catalyzed Cascade Cyclization Featuring B-H and C-H Activation: One-Step Construction of Carborane-Fused N-Polyheterocycles. Chem. Sci. 2018, 9, 6390-6394 (Highlighted in Synfacts, Synfacts 2018, 14, 0924).