郑清炳
高级工程师
个人简介
教育经历 2003.9-2007.6 学士,生物技术专业,生命科学学院,厦门大学 2007.8-2013.9 博士(硕博连读),细胞生物学专业,生命科学学院,厦门大学,导师:张军教授 工作经历 2019.8-至今 厦门大学公共卫生学院高级工程师,冷冻电镜平台负责人 2016.10-2016.12 加州大学洛杉矶分校(UCLA),访问学者 2013.9-2019.7 厦门大学公共卫生学院工程师,冷冻电镜平台负责人
研究领域
高分辨冷冻电镜结构生物学 结构疫苗学
近期论文
(1) Zheng, Q.#, Zhu, R.#, Xu, L.#, He, M.#, Yan, X.#, Liu, D., Yin, Z., Wu, Y., Li, Y., Yang, L., Hou, W., Li, S., Li, Z., Chen, Z., Li, Z., Yu, H., Gu, Y., Zhang, J., Baker, T. S., Zhou, Z. H., Graham, B. S. *, Cheng, T. *, Li, S. *, and Xia, N*. (2019) Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization, Nature microbiology 4, 124-133. (# co-first authors) (2) Zheng, Q.#, Jiang, J.#, He, M.#, Zheng, Z.#, Yu, H., Li, T., Xue, W., Tang, Z., Ying, D., Li, Z. et al. (2019) Viral neutralization by antibody-imposed physical disruption, PNAS 116 (52), 26933-26940. (# co-first authors) (3) He M.#, Xu L.#, Zheng Q.#, Zhu R.#, Yin Z.#, Zha Z., Lin Y., Yang L., Huang Y., Ye X. et al. (2020) Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16, Cell Host Microbe 27(2):249-261 e245. (# co-first authors) (4) Zhu, R.#, Xu, L.#, Zheng, Q.#, Cui, Y.#, Li, S.#, He, M., Yin, Z., Liu, D., Li, S., Li, Z., Chen, Z., Yu, H., Que, Y., Liu, C., Kong, Z., Zhang, J., Baker, T. S., Yan, X.*, Hong Zhou, Z.*, Cheng, T.*, and Xia, N*. (2018) Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10, Science advances 4, eaat7459. (# co-first authors) (5) Xu, L.#, Zheng, Q.#, Li, S.#, He, M., Wu, Y., Li, Y., Zhu, R., Yu, H., Hong, Q., Jiang, J., Li, Z., Li, S., Zhao, H., Yang, L., Hou, W., Wang, W., Ye, X., Zhang, J., Baker, T. S., Cheng, T.*, Zhou, Z. H.*, Yan, X.*, and Xia, N*. (2017) Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody, Nature communications8, 505. (# co-first authors) (6) Li, Z., Song, S., He, M., Wang, D., Shi, J., Liu, X., Li, Y., Chi, X., Wei, S., Yang, Y., Wang, Z., Li, J., Qian, H., Yu, H., Zheng, Q., Yan, X., Zhao, Q., Zhang, J., Gu, Y., Li, S., and Xia, N. (2018) Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity, Nature communications9, 5360. (7) Shen, C., Chen, J., Li, R., Zhang, M., Wang, G., Stegalkina, S., Zhang, L., Chen, J., Cao, J., Bi, X., Anderson, S. F., Alefantis, T., Zhang, M., Cai, X., Yang, K., Zheng, Q., Fang, M., Yu, H., Luo, W., Zheng, Z., Yuan, Q., Zhang, J., Wai-Kuo Shih, J., Kleanthous, H., Chen, H., Chen, Y., and Xia, N. (2017) A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses, Science translational medicine9. (8) Zhang, P., Chen, Y., Zeng, Y., Shen, C., Li, R., Guo, Z., Li, S., Zheng, Q., Chu, C., Wang, Z., Zheng, Z., Tian, R., Ge, S., Zhang, X., Xia, N. S., Liu, G., and Chen, X. (2015) Virus-mimetic nanovesicles as a versatile antigen-delivery system, Proc Natl Acad Sci112, E6129-6138. (9) Zhang, T. Y., Guo, X. R., Wu, Y. T., Kang, X. Z., Zheng, Q. B., Qi, R. Y., Chen, B. B., Lan, Y., Wei, M., Wang, S. J., Xiong, H. L., Cao, J. L., Zhang, B. H., Qiao, X. Y., Huang, X. F., Wang, Y. B., Fang, M. J., Zhang, Y. L., Cheng, T., Chen, Y. X., Zhao, Q. J., Li, S. W., Ge, S. X., Chen, P. J., Zhang, J., Yuan, Q., and Xia, N. S. (2019) A unique B cell epitope-based particulate vaccine shows effective suppression of hepatitis B surface antigen in mice, Gut pii: gutjnl-2018-317725. (10) Shen, C., Zhang, M., Chen, Y., Zhang, L., Wang, G., Chen, J., Chen, S., Li, Z., Wei, F., Chen, J., Yang, K., Guo, S., Wang, Y., Zheng, Q., Yu, H., Luo, W., Zhang, J., Chen, H., Chen, Y., and Xia, N. (2019) An IgM antibody targeting the receptor binding site of influenza B blocks viral infection with great breadth and potency, Theranostics9, 210-231. (11) Wei, M., Wang, D., Li, Z., Song, S., Kong, X., Mo, X., Yang, Y., He, M., Li, Z., Huang, B., Lin, Z., Pan, H., Zheng, Q., Yu, H., Gu, Y., Zhang, J., Li, S., and Xia, N. (2018) N-terminal truncations on L1 proteins of human papillomaviruses promote their soluble expression in Escherichia coli and self-assembly in vitro, Emerging microbes & infections7, 160. (12) Lin, Q., Li, T., Chen, Y., Lau, S. Y., Wei, M., Zhang, Y., Zhang, Z., Yao, Q., Li, J., Li, Z., Wang, D., Zheng, Q., Yu, H., Gu, Y., Zhang, J., Chen, H., Li, S., and Xia, N. (2018) Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus, Journal of virology92. (13) Li, Z., Wang, D., Gu, Y., Song, S., He, M., Shi, J., Liu, X., Wei, S., Li, J., Yu, H., Zheng, Q., Yan, X., Baker, T. S., Zhang, J., McLellan, J. S., Li, S., and Xia, N. (2017) Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus, mBio8. (14) Li, Z., Yan, X., Yu, H., Wang, D., Song, S., Li, Y., He, M., Hong, Q., Zheng, Q., Zhao, Q., Gu, Y., Zhang, J., Janssen, M. E., Cardone, G., Olson, N. H., Baker, T. S., Li, S., and Xia, N. (2016) The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction, Structure24, 874-885. (15) Yang, L., Liu, Y., Li, S., Zhao, H., Lin, Q., Yu, H., Huang, X., Zheng, Q., Cheng, T., and Xia, N. (2016) A novel inactivated enterovirus 71 vaccine can elicit cross-protective immunity against coxsackievirus A16 in mice, Vaccine34, 5938-5945.