2013.03-至今 厦门大学公共卫生学院，教授 2007.12-2013.03 中山大学公共卫生学院，教授 2004.05-2005.11 美国国家毒理研究中心，访问学者 2002.09-2006.06 中山大学，卫生毒理学博士 2000.06-2000.12 新加坡国立大学，高级访问学者 1998.07-2007.12 中山(医科)大学公共卫生学院，讲师、副教授 1995.08-1998.06 中山医科大学，环境卫生学硕士 1991.07-1995.08 福建医学院预防医学系，助教 1986.09-1991.07 福建医学院，预防医学学士

生化与分子毒理学、免疫毒理学，开展环境因素靶向(亚)细胞器毒作用介导调节性细胞死亡和化学致癌的信号通路及其分子调控机制研究。

(1) Che L#, Yao H#, Yang C, Guo N, Huang J, Wu Z, Zhang L, Chen Y, Liu G, Lin Z*, Lin Y*. Cyclooxygenase-2 modulates ER-mitochondria crosstalk to mediate superparamagnetic iron oxide nanoparticles induced hepatotoxicity: an in vitro and in vivo study. Nanotoxicology, 2020;14(2):162-180. (2) Chen YY#, Wang WH#, Che L#, Lan Y, Zhang LY, Zhan DL, Huang ZY, Lin ZN*, LinYC*. BNIP3L-dependent mitophagy promotes HBx-induced cancer stemness of hepatocellular carcinoma cells via glycolysis metabolism reprogramming. Cancers (Basel), 2020;12(3). pii: E655. (3) Zhang LY#, Zhan DL#, Chen YY, Wang WH, He CY, Lin Y, Lin YC*, Lin ZN*. Aflatoxin B1 enhances pyroptosis of hepatocytes and activation of Kupffer cells to promote liver inflammatory injury via dephosphorylation of cyclooxygenase-2: an in vitro, ex vivo and in vivo study. Arch Toxicol, 2019;93(11):3305-3320. (4) Zhang S#, Che L#, He C, Huang J, Guo N, Shi J, Lin Y*, Lin Z*. Drp1 and RB interaction to mediate mitochondria-dependent necroptosis induced by cadmium in hepatocytes. Cell Death Dis, 2019;10(7):523. (5) He C#, Jiang S#, Yao H#, Zhang L, Yang C, Jiang S, Ruan F, Zhan D, Liu G, Lin Z*, LinY*, Chen X. High-content analysis for mitophagy response to nanoparticles: A potential sensitive biomarker for nanosafety assessment. Nanomed: NBM (Nanotechnol Biol Med),2019;15(1):59-69. (6) Yang C, Han P, Ruan F, Zhou T, Luo B, Qiu Y, Lin Y, Lin Z*, He C*. Lactational exposure to environmentally relevant benzo(a)pyrene causes astrocytic activation and anxiety-like behavior in male mice. Chemosphere, 2019;221:67-74. (7) Chen YY#, Lin Y#, Han PY#, Jiang S, Che L, He CY, Lin YC*, Lin ZN*. HBx combined with AFB1 triggers hepatic steatosis via COX-2-mediated necrosome formation and mitochondrial dynamics disorder. J Cell Mol Med, 2019;23(9):5920-5933. (8) Zhang Y#, Dong T#, Hu W, Wang X, Xu B, Lin Z, Hofer T, Stefanoff P, Chen Y, Wang X, Xia Y*. Association between exposure to a mixture of phenols, pesticides, and phthalates and obesity: Comparison of three statistical models. Environ Int, 2019;123: 325-336. (9) He C#, Jiang S#, Yao H#, Zhang L, Yang C, Zhan D, Lin G, Zeng Y, Xia Y, Lin Z*, Liu G*, Lin Y*. Endoplasmic reticulum stress mediates inflammatory response triggered by ultra-small superparamagnetic iron oxide nanoparticles in hepatocytes. Nanotoxicology, 2018;12(10):1198-1214. (10) He C#, Qiu Y#, Han P#, Chen Y, Zhang L, Yuan Q, Zhang T, Cheng T, Yuan L, Huang C, Zhang S, Yin Z, Peng X, Liang D, Lin X, Lin Y*, Lin Z*, Xia N. ER stress regulating protein phosphatase 2A-B56γ, targeted by hepatitis B virus X protein, induces cell cycle arrest and apoptosis of hepatocytes. Cell Death Dis, 2018;9(7):762. (11) Jiang S#, Lin Y#, Yao H#, Yang C, Zhang L, Luo B, Lei Z, Cao L, Lin N, Liu X*, Lin Z*, He C*. The role of unfolded protein response and ER-phagy in quantum dots-induced nephrotoxicity: an in vitro and in vivo study. Arch Toxicol, 2018;92(4):1421-1434. (12) Zhou TJ, Zhang SL, He CY, Zhuang QY, Han PY, Jiang SW, Yao H, Huang YJ, Ling WH, Lin YC*, Lin ZN*. Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin related-protein 1. Theranostics, 2017;7(5):1389-1406. (13) Nguyen DV, Jiang SW, He CY, Lin ZN*, Lin NB, Nguyen AT, Kang LF, Han MY, Liu XY*. Elevating biomedical performance of ZnO/SiO2@ amorphous calcium phosphate- bioinspiration making possible the impossible. Adv Funct Mater, 2016;26(38):6921-6929. (14) Zhuang Q#, Zhou T#, He C, Zhang S, Qiu Y, Luo B, Zhao R, Liu H, Lin Y*, Lin Z*. Protein phosphatase 2A-B55δ enhances chemotherapy sensitivity of human hepatocellular carcinoma under the regulation of microRNA-133b. J Exp Clin Canc Res, 2016;35:67. (15) Luo B#, Lin Y#, Jiang S, Huang L, Yao H, Zhuang Q, Zhao R, Liu H, He C*, Lin Z*. Endoplasmic reticulum stress eIF2α-ATF4 pathway-mediated cyclooxygenase-2 induction regulates cadmium-induced autophagy in kidney. Cell Death Dis, 2016;7(6):e2251. (16) He C#, Jiang S#, Jin H#, Chen S, Lin G, Yao H, Wang X, Mi P, Ji Z, Lin Y*, Lin Z*, Liu G*. Mitochondrial electron transport chain identified as a novel molecular target of SPIO nanoparticles mediated cancer-specific cytotoxicity.Biomaterials, 2016;83:102-114. (17) Chen S#, Zhang J#, Jiang S, Lin G, Luo B, Yao H, Lin Y, He C, Liu G*, Lin Z*. Self-assembled superparamagnetic iron oxide nanoclusters for universal cell labeling and MRI. Nanoscale Res Lett,2016;11(1):263. (18) Liao K#, Xia B#, Zhuang QY, Hou MJ, Zhang YJ, Luo B, Qiu Y, Gao YF, Li XJ, Chen HF, Ling WH, Huang YJ, He CY, Lin YC*, Lin ZN*. Parthenolide inhibits cancer stem-like side population of nasopharyngeal carcinoma cells via suppression of the NF-κB/COX-2 pathway. Theranostics, 2015;5(3):302-321. (19) 张力引，林育纯，林忠宁*. 外源物诱导肝脏局部先天免疫反应的线粒体调控机制. 环境与职业医学，2019;36(8):781-790. (20) 韩佩宇，车琳，陈圆圆，江珊，段军燕，孙宝芳，何承勇，林育纯，林忠宁*. CRISPR/Cas9敲低环氧合酶2表达对黄曲霉毒素B1诱导肝细胞核DNA 损伤与脂质蓄积的影响. 厦门大学学报(自然科学版)，2018;57(5):634-642. (21) 姚欢，林育纯，林忠宁*. 线粒体关联性内质网膜与细胞Ca2+依赖性死亡的研究进展. 癌变·畸变·突变，2018;30(3):242-247. (22) 张仕利，林育纯，林忠宁*. 线粒体质量控制在外源化学物诱导坏死性凋亡中的作用. 中国职业医学，2018;45(2):239-243. (23) 庄群瑛，林育纯，林忠宁*. 蛋白磷酸酶2A调控细胞周期发挥抗肿瘤作用的研究进展. 癌变·畸变·突变，2016;28(2):155-157,161. (24) 邱杨，王冬梅，林忠宁*. 乙型肝炎病毒X蛋白与肝细胞内质网应激. 世界华人消化杂志，2016;24(7):1040-1047. (25) 骆冰，何承勇，林忠宁*. 环氧合酶-2参与环境因素诱导毒性损伤的研究进展. 环境与职业医学，2016;33(7):711-716.