郑凌 照片

郑凌

教授 博导

所属大学: 武汉大学

所属学院: 生命科学学院

邮箱:
lzheng@whu.edu.cn

个人主页:
https://bio.whu.edu.cn/info/1499/9456.htm

个人简介

学习经历 1992 年 - 1996 年,就读于武汉大学生物系,获学士学位。 1996 年 - 1999 年,在华南农业大学攻读植物细胞分子生物学专业,获硕士学位。 2000 年 - 2005 年,于凯西西储大学(Case Western Reserve University)药理系学习,获博士学位。 2005 年-2007 年,在凯西西储大学(Case Western Reserve University)医学系从事博士后研究工作。 主要工作经历与任职情况 2007 年 - 2008 年,担任凯西西储大学(Case Western Reserve University)医学系讲师。 2008 年-至今,担任武汉大学生命科学学院教授。

研究领域

代谢疾病发病机制和治疗

近期论文

1) Chen H, Liu C, Wang Q, Xiong M, Zeng X, Yang D, Xie Y, Su H, Zhang Y, Huang Y, Chen Y, Yue J, Liu C, Wang S, Huang K*, Zheng L*. Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver. Nature communications. 2022, 13(1):3835. 2) Huang Y, Xie Y, Yang D, Xiong M, Chen X, Wu D, Wang Q, Chen H, Zheng L*, Huang K*. Histone demethylase UTX aggravates acetaminophen overdose induced hepatotoxicity through dual mechanisms. Pharmacological research. 2021, 175:106021. 3) Sun Y, Wang Q, Zhang Y, Geng M, Wei Y, Liu Y, Liu S, Petersen RB, Yue J, Huang K*, Zheng L*.Multigenerational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p. Journal of hepatology. 2020, 73(3):603-615. 4) Zhang W, Yang D, Yuan Y, Liu C, Chen H, Zhang Y, Wang Q, Petersen RB, Huang K*, Zheng L*.Muscular G9a Regulates Muscle-Liver-Fat Axis by Musclin Under Overnutrition in Female Mice. Diabetes. 2020, 69(12):2642-2654. 5) Liu C, Wang J, Wei Y, Zhang W, Geng M, Yuan Y, Chen Y, Sun Y, Chen H, Zhang Y, Xiong M, Li Y, Zheng L*, Huang K*. Fat-Specific Knockout of Mecp2 Upregulates Slpi to Reduce Obesity by Enhancing Browning. Diabetes. 2020. 69(1):35-47 . 6) Zhang Y, Xue W, Zhang W, Yuan Y, Zhu X, Wang Q, Wei Y, Yang D, Yang C, Chen Y, Sun Y, Wang S, Huang K*, Zheng L*. Histone methyltransferase G9a protects against acute liver injury through GSTP1. Cell death & differentiation. 2020, 27(4):1243-1258. 7) Li J, Lu D, Dou H, Liu H, Weaver K, Wang W, Li J, Yeh ETH, Williams BO, Zheng L*, Yang T*. Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway. Nature communications. 2018; 9(1):143. 8) Liu S, Sun Y, Jiang M, Li Y, Tian Y, Xue W, Ding N, Sun Y, Cheng C, Li J, Miao X, Liu X, Zheng L* and Huang K*. Glyceraldehyde-3-phosphate dehydrogenase promotes liver tumorigenesis by modulating phosphoglycerate dehydrogenase. Hepatology. 2017; 66(2):631-645. 9) Wang W, Wang Q, Wan D, Sun Y, Wang L, Chen H, Liu C, Petersen RB, Li J, Xue W, Zheng L* and Huang K*. Histone HIST1H1C/H1.2 regulates autophagy in the development of diabetic retinopathy. Autophagy. 2017; 13(5):941-954. 10) Li J, Huang J, Li JS, Chen H, Huang K* and Zheng L*. Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets. Journal of hepatology. 2012; 56(4):900-907.