学习经历 2001 年 09 月－2005 年 06 月，就读于中国地质大学外国语学院英语专业，获学士学位。 2003 年 02 月－2005 年 06 月，同时在武汉大学生命科学学院生物科学专业学习，获学士学位。 2005 年 09 月－2010 年 06 月，于武汉大学生命科学学院攻读细胞生物学专业，获博士学位。 工作经历 2010 年 07 月－2013 年 02 月，在 UT MD Anderson Cancer Center 担任博士后。 2013 年 03 月－至今，任职于武汉大学生命科学学院、医学研究院，教育部免疫代谢前沿科学中心，职位为教授。

炎症与肿瘤微环境的免疫调节

1. Xiong TC#, Wei MC#, Li FX#, Shi M, Gan H, Tang Z, Dong HP, Liuyu T, Gao P, Zhong B*, Zhang ZD*, Lin D*. The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS. Nat Commun, 2022, Accepted. 2. Zhong B* and Shu HB*. MITA/STING-mediated antiviral immunity and autoimmunity: the evolution, mechanism and intervention. Current Opinion in Immunology, 2022, In press. 3. An R, Wang P, Guo H, Liuyu T, Zhong B*, Zhang ZD*. USP2 promotes experimental colitis and bacterial infections by inhibiting the proliferation of myeloid cells and remodeling the extracellular matrix network. Cell Insight, 2022, 1(4): 100047. doi: 10.1016/j.cellin.2022.100047. 4. Zhang ZD, Li HX, Gan H, Tang Z, Guo YY, Yao SQ, Liuyu T, Zhong B*, Lin D*. RNF115 inhibits the post-ER trafficking of TLRs and TLRs-mediated immune responses by catalyzing K11-linked ubiquitination of RAB1A and RAB13. Adv Sci, 2022, 9(16): 2105391. doi: 10.1002/advs.202105391. 5. Yang W#, Dong HP#, Wang P#, Xu ZG, Xian J, Chen J, Wu H, Lou Y, Lin D*, Zhong B*. IL-36g and IL-36Ra reciprocally regulate colon tumorigenesis by modulating the cell-matrix adhesion network and Wnt signaling. Adv Sci, 2022, 9(10): 2103035. doi: 10.1002/advs.202103035. 6. Zhang ZD, Zhong B*. Regulation and function of the cGAS-MITA/STING axis in health and disease. Cell Insight, 2022, 1(1): 100001. doi: 10.1016/j.cellin.2021.100001. 7. Wang P#, Yang W#, Guo H, Dong HP, Guo YY, Gan H, Wang Z, Cheng Y, Deng Y, Xie S, Yang X, Lin D*, Zhong B*. IL-36g and IL-36Ra reciprocally regulate NSCLC progression by modulating GSH homeostasis and oxidative stress-induced cell death. Adv Sci, 2021, 8(19): 2101501. doi: 10.1002/advs.202101501. 8. Zhang M#, Yang W#, Wang P, Deng Y, Dong YT, Liu FF, Huang R, Zhang P, Duan YQ, Liu XD, Lin D*, Chu Q*, Zhong B*. CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer. Nat Commun, 2020, 11: 6119. Nov 30, doi: 10.1038/s41467-020-19973-6. 9. Zhang ZD#, Xiong TC#, Yao SQ, Wei MC, Chen M, Lin D, Zhong B*. RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA. Nat Commun, 2020, 11: 5536. Nov 2, doi: 10.1038/s41467-020-19318-3. 10. Wang XM, Yang C, Zhao Y, Xu Z, Yang W, Wang P, Lin D, Xiong B, Fang J, Dong C, Zhong B*. The deubiquitinase USP25 supports colonic inflammation and bacterial infection and promotes colorectal cancer. Nat Cancer, 2020, 1: 811-825. July 6, doi: 10.1038/s43018-020-0089-4. 11. Zhang Q, Tang Z, An R, Ye L, Zhong B*. USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity. Cell Res, 2020, 30, 914-927. May 26, doi: 10.1038/s41422-020-0341-6. 12. Cai Z, Zhang MX, Tang Z, Zhang Q, Ye J, Xiong TC, Zhang ZD, Zhong B*. USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2. J Exp. Med., 2020, 217, 5: e20191174. 13. Li SZ*, Shu QP, Song Y, Zhang HH, Liu Y, Jin BX, Liuyu TZ, Li C, Huang XC, Du RL, Song W*, Zhong B*, Zhang XD*. Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response. Nat Commun, 2019, 10(1): 3233. 14. Ye L#, Zhang Q#, Liuyu T, Xu Z, Zhang MX, Luo MH, Zeng WB, Zhu Q, Lin D*, Zhong B*. USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA. Plos Pathog, 2019, 15(4): e1007680. 15. Zhang MX, Cai Z, Zhang M, Wang XM, Wang Y, Zhao F, Zhou J, Luo MH, Zhu Q, Xu Z, Zeng WB*, Zhong B*, Lin D*. USP20 promotes cellular antiviral responses via deconjugating K48-linked ubiquitination of MITA. J Immunol, 2019, 202(8):2397-2406.