赵晓璐
副教授 硕导
个人简介
学习经历 1999-2003 年,就读于武汉大学生命科学学院,获学士学位。 2004-2006 年,在 University of Southern Denmark 攻读生物化学与分子生物学专业,获博士学位。 2007-2011 年,于 University of Southern Denmark 继续深造生物化学与分子生物学,获硕士学位。 主要工作经历及任职情况 2012-2014 年,任武汉大学生命科学学院讲师。 2014 年至今,担任武汉大学生命科学学院副教授。 2016 年,任美国宾夕法尼亚大学生物化学和生物物理学系访问副教授。
研究领域
基于质谱技术的代谢生物学
近期论文
1) Zhao N, Deng G, Yuan PX, Zhang YF, Jiang LY, Zhao X*, Song BL*. TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport. J Lipid Res. 64(12):100465, 2023 2) Zhou YX , Wei J, Deng G, Hu A, Sun PY, Zhao X, Song BL, Luo J. Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesis. Nat Cell Biol, 25(7):937-949, 2023. 3) Hu A#, Zhang JZ#, Wang J, Li CC, Yuan M, Deng G, Lin ZC, Qiu ZP, Liu HY, Wang XW, Wei PC, He X, Zhao X*, Qiu WW*, Song BL*. Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate. Cell Res, 32(3):288-301, 2022. 4) Miao M*, Yuan M, Xiong X, Qiu Y, Deng G, Yu F, Huang W, Bai S, Zhou X*, Zhao X*. Enterovirus 71 3C proteolytically processes the histone H3 N-terminal tail during infection. Virol Sin, 37(2):314-317, 2022. 5) Wang JQ, Li LL, HuA, Deng G, Wei J, Li YF, Liu YB, Lu XY, Qiu ZP, Shi XJ, Zhao X, Luo J, Song BL. Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion. Nature, 608(7922):413-420, 2022. 6) Wang JK, Li Y, Zhao X, Liu YB, Tan J, Xing YY, Adi D, Wang YT, Fu ZY, Ma YT, Liu SM, Liu Y, Wang Y, Shi XJ, Lu XY, Song BL, Luo J. Ablation of Plasma Prekallikrein Decreases LDL Cholesterol by Stabilizing LDL Receptor and Protects against Atherosclerosis. Circulation, 145(9):675-687, 2022. 7) Lu XY, Shi XJ, Hu A, Wang JQ, Ding Y, Jiang W, Sun M, Zhao X, Luo J, Qi W, Song BL. Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis. Nature. 588(7838):479-484, 2020. 8) Yang F#, Wang D#, Tong Y, Qin C, Yang L, Yu F, Huang X, Liu S, Cao Z, Guo L, Li W, Wu Y*, Zhao X*. Thermostable potassium channel-inhibiting neurotoxins in processed scorpion medicinal material revealed by proteomic analysis: Implications of its pharmaceutical basis in traditional Chinese medicine. J Proteomics, 206:103435, 2019. 9) Li QL#, Wang DY#, Ju LG, Yao J, Gao C, Lei PJ, Li LY, Zhao X*, Wu M*. The hyper-activation of transcriptional enhancers in breast cancer. Clin Epigenetics. 11(1):48, 2019. 10) Miao M, Yu F, Wang D, Tong Y, Yang L, Xu J, Qiu Y, Zhou X*, Zhao X*. Proteomics Profiling of Host Cell Response via Protein Expression and Phosphorylation upon Dengue Virus Infection. Virol Sin. 34(5):549-562, 2019. 11) Guo Q, Sidoli S, Garcia BA*, Zhao X*. Assessment of Quantification Precision of Histone Post-Translational Modifications by Using an Ion Trap and down To 50 000 Cells as Starting Material. J Proteome Res. 17(1):234-242, 2018. 12) Kori Y, Sidoli S, Yuan ZF, Lund PJ, Zhao X*, Garcia BA*. Proteome-wide acetylation dynamics in human cells. Sci Rep. 7(1):10296, 2017. 13) Wang W, Sidoli S, Zhang W, Wang Q, Wang L, Jensen ON, Guo L, Zhao X*, Zheng L*. Abnormal levels of histone methylation in the retinas of diabetic rats are reversed by minocycline treatment. Sci Rep. 7:45103, 2017. 14) Zhu X, Li H, Guo L, Zhao X*. Phosphoproteomic Analysis Based on Liquid Chromatography-Tandem Mass Spectrometry. Journal of Analytical Science. 32(1):7-12, 2016.