学习经历 1983 年 - 1987 年，就读于武汉大学，专业为病毒学及分子生物学，获学士学位。 1995 年 - 1998 年，在武汉大学攻读微生物学专业，获博士学位。 1999 年 - 2000 年，于美国贝勒医学院生物化学及分子生物学系从事博士后研究。 2000 年 - 2002 年，在美国德州大学医学院内科系担任博士后。 工作经历 1988 年 - 1994 年，在武汉大学病毒研究所，先后担任助教、讲师。 2003 年 - 至今，担任武汉大学生命科学学院教授。 2005 年 - 至今，担任病毒学国家重点实验室 PI。 2005 年 - 2007 年，获湖北省杰出青年基金资助。 2007 年 - 2010 年，入选教育部 “新世纪人才计划”。

病毒感染与宿主炎症应答；重组病毒载体疫苗

Zuo Q, Cheng Z, Zhang G, Xia Y, Xu G, Cao W, Yang X, Fu Y, He R, Fang P, Guo Y, Nie L, Huang Y, Liu L, Zhan J, Liu S, Zhu Y*. Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.J Immunol. 2021 Jun 18, 207(2):577-589 Xu G, Deng F, Zuo Q, Liu L, Dou K, Cheng Z, Cao W, Luo C, Yu C, Liu S, Zhu Y*. Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation. Cell Mol Immunol. 2021 Jun;18(6):1587-1589. Cao W, Guo Y, Cheng Z, Xu G, Zuo Q, Nie L, Huang Y, Liu S, Zhu Y*. Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6. J Immunol. 2021 Jun 1;206(11):2668-2681. Deng F, Xu G, Cheng Z, Huang Y, Ma C, Luo C, Yu C, Wang J, Xu X, Liu S, Zhu Y*. Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex. Front Immunol. 2021 Feb 25;12:618196. Xia Z, Xu G, Nie L, Liu L, Peng N, He Q, Zuo Q, Zhou Y, Cao Z, Liu S, Zhu Y*. NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1. J Immunol. 2019 Aug 15;203(4):1001-1011. Liu S, Liu L, Xu G, Cao Z, Wang Q, Li S, Peng N, Yin J, Yu H, Li M, Xia Z, Zhou L, Lin Y, Wang X, Li Q, Zhu C, Yang X, Wang J, She Y, Lu M, Zhu Y*. Epigenetic modification is regulated by the interaction of influenza A virus nonstructural protein-1 with the de novo DNA methyltransferase DNMT3B and subsequent transport to the cytoplasm for K48-linked polyubiquitination. J Virol. 2019 Mar 21;93(7). pii: e01587-18. Zhou Y, Xia Z, Cheng Z, Xu G, Yang X, Liu S, Zhu Y*. Inducible microRNA-590-5p inhibits host antiviral response by targeting the soluble IL-6 receptor. J Biol Chem. 2018 Nov 23;293(47):18168-18179. He QQ, Ren S, Xia ZC, Cheng ZK, Peng NF, Zhu Y*. Fibronectin Facilitates Enterovirus 71 Infection by Mediating Viral Entry. J Virol. 2018 Apr 13;92(9). pii: e02251-17. Xia Z, Xu G, Yang X, Peng N, Zuo Q, Zhu S, Hao H, Liu S, Zhu Y*. Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex. J Immunol. 2017 May 1;198(9):3690-3704. Wan Y, Cao W, Han T, Ren S, Feng J, Chen T, Wang J, Broering R, Lu M, Zhu Y*. Inducible Rubicon facilitates viral replication by antagonizing interferon production. Cell Mol Immunol. 2017 Jul;14(7):607-620. Feng J, Cao Z, Wang L, Wan Y, Peng N, Wang Q, Chen X, Zhou Y, Zhu Y*. Inducible GBP5 Mediates the Antiviral Response via Interferon-Related Pathways during Influenza A Virus Infection. J Innate Immunity 2017;9:419–435 Yang X, Hao H, Xia Z, Xu G, Cao Z, Chen X, Liu S, Zhu Y* Soluble IL-6 Receptor and IL-27 Subunit p28 Protein Complex Mediate the Antiviral Response through the Type III IFN Pathway.. J Immunol. 2016 Sep 15;197(6):2369-81. Wang L, Zhu S, Xu G, Feng J, Han T, Zhao F, She YL, Liu S, Ye L, Zhu Y*. Gene expression and antiviral activity of interleukin-35 in response to influenza A virus infection. J Biol Chem. 2016 Aug 5;291(32):16863-76. Peng N#, Liu S#, Xia Z, Ren S, Feng J, Jing M, Gao X, Wiemer EA, Zhu Y*. Inducible Major Vault Protein Plays a Pivotal Role in Double-Stranded RNA- or Virus-Induced Proinflammatory Response. J Immunol. 2016. 196(6):2753-66. Liu S, Peng NF, Xie JJ, Hao Q, Zhang M, Zhang Y, Xia ZC, Xu G, Zhao FP, Wang Q, Han T, Zhu Y*, Human hepatitis B virus S and E antigens inhibit major vault protein signaling in interferon induction pathways. Journal of Hepatology 2015, 62. 1015–1023. Han T, Wan Y, Wang J, Zhao P, Yuan Y, Wang L, She Y, Broering R, Lu M, Ye L, Zhu Y*. Set7 facilitates hepatitis C virus replication via enzymatic activity-dependent attenuation of the IFN-related pathway. J Immunol. 2015, 194(6):2757-68. Zhao F, Xu G, Zhou Y, Wang L, Xie J, Ren S, Liu S, Zhu Y*. MicroRNA-26b Inhibits Hepatitis B Virus Transcription and Replication by Targeting the Host Factor CHORDC1 Protein. J Biol Chem. 2014, 289(50):35029-41. Wang J, Wang Q, Han T, Li YK, Zhu SL, Ao F, Feng J, Jing MZ, Wang L, Ye LB and Zhu Y*. Soluble interleukin-6 receptor is elevated during influenza A virus infection and mediates the IL-6 and IL-32 inflammatory cytokine burst Cellular & Molecular Immunology. 2014, 1–12 (In Press) Li Y, Xie J, Xu X, Wang J, Ao F, Wan Y, Zhu Y*. MicroRNA-548 down-regulates host antiviral response via direct targeting of IFN-λ1. Protein Cell. 2013.4(2):130-41.