学习经历 1988 - 1992，武汉大学，病毒及分子生物学系，获学士学位 1996 - 2002，武汉大学生命科学学院，获硕士、博士学位 主要工作经历与任职 1992 - 1996，卫生部武汉生物制品研究所，实习研究员 2001 - 2007，武汉大学生命科学学院，历任助教、讲师、副教授 2005 - 2007，美国 Stanford 大学医学院，博士后 2007 - 至今，武汉大学基础医学院，教授、博导 2013 - 至今，武汉大学，“珞珈学者”

专注于病毒诱发的疾病机制、诊断标志物和治疗策略，研究兴趣集中在DNA和RNA逆转录病毒致病机制及其临床转归，具体方向包括：①人内源性逆转录病毒（HERVs）介导神经细胞病理损伤并导致神经精神疾病的机制，探索基于抗体治疗方案的可行性；②乙型肝炎病毒（HBV）在慢性肝炎（CHB）及肝细胞肝癌（HCC）中的致病机制，重点是HBV在HCC耐药中的作用与机制，探讨HCC生物药物治疗的新途径。

10篇代表性论文（*通讯作者，#并列第一作者） ①Shuang Ding#, Haibin Liu#, Lijuan Liu, Li Ma, Zhen Chen, Miao Zhu, Lishi Liu, Xueyan Zhang, Haojie Hao, Li Zuo, Jingwen Yang, Xiulin Wu, Ping Zhou, Huang Fang, Fan Zhu*（朱帆，通讯作者）, Wuxiang Guan*. Epigenetic addition of m5C to HBV transcripts promotes viral replication and evasion of innate antiviral responses. Cell Death Dis. 2024 Jan 12; 15(1):39 ②Wenshi Li, Xing Xue, Xuhang Li, Xiulin Wu, Ping Zhou, Yaru Xia, Jiahang Zhang, Mengqi Zhang, Fan Zhu*（朱帆，通讯作者）. Ancestral Retrovirus Envelope Protein ERVWE1 Upregulates Circ_0001810, a Potential Biomarker for Schizophrenia, and induces Neuronal Mitochondrial Dysfunction via activating AK2. Cell Biosci. 2024 Nov 14; 14(1):138 ③Zhao Lv#, Lijuan Liu#, Jian You, Ping Zhou, Yaru Su, Kexin Zhao, Jiahang Zhang, Fan Zhu*（朱帆，通讯作者）. Small HBV surface antigen (SHBs) Drives Regorafenib Resistance in HCC via KIAA1429-Dependent m6A modification of CCR9. J Med Virol. 2024 Sep; 96(9):e29894 ④Xiulin Wu, Lianzhong Liu, Xing Xue, Xuhang Li, Kexin Zhao, Jiahang Zhang, Wenshi Li, Wei Yao, Shuang Ding, Chen Jia, Fan Zhu*（朱帆，通讯作者）. Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms. Cell Biosci. 2023 Nov 21; 13:213 ⑤Youyi Liu, Lijuan Liu, Yan Zhou, Ping Zhou, Qiujin Yan, Xiaobei Chen, Shuang Ding, Fan Zhu*（朱帆，通讯作者）. CKLF1 Enhances Inflammation-mediated Carcinogenesis and Prevents Doxorubicin-induced Apoptosis via IL-6/STAT3 Signaling in HCC. Clin Cancer Res. 2019 Jul 1; 25(13):4141-4154 ⑥Xiuling Wang#, Zhongchun Liu#, Peigang Wang, Shan Li, Jie Zeng, Xiaoning Tu, Qiujin Yan, Zheman Xiao, Mengxian Pan, Fan Zhu*（朱帆，通讯作者）. Syncytin-1, an endogenous retroviral protein, triggers the activation of CRP via TLR3 signal cascade in glial cells. Brain Behav Immun. 2018 Jan; 67:324-334 ⑦Honglian Yu#, Tao Liu#, Zhankui Zhao, Yatang Chen , Jie Zeng , Shaojun Liu, Fan Zhu*（朱帆，通讯作者）. Mutations in 3' long terminal repeat of HERV-W family in chromosome 7 upregulate syncytin-1 expression in urothelial cell carcinoma of the bladder through interacting with c-Myb. Oncogene. 2014 Jul 24; 33(30): 3947-58 ⑧Lijuan Liu#, Xiaobei Chen#, Shuixiang Xie, Chuanjie Zhang, Zhenpeng Qiu, Fan Zhu*（朱帆，通讯作者）. Variant 1 of KIAA0101, overexpressed in hepatocelluler carcinoma, prevents Doxorubicin-induced apoptosis by inhibiting p53 activation. Hepatology. 2012 Nov; 56 (5): 1760-9 ⑨Wenjie Huang#, Shan Li#, Yuanmin Hu, Hongnian Yu, Feng Luo, Qi Zhang, Fan Zhu*（朱帆，通讯作者）. Implication of the env Gene of the Human Endogenous Retrovirus W Family in the Expression of BDNF and DRD3 and Development of Recent-Onset Schizophrenia. Schizophr Bull. 2011 Sep; 37: 988-1000 ⑩Wei Wei, WenJie Huang, Yin Pan, Fan Zhu*（朱帆，通讯作者）, JianGuo Wu*. Functional switch of viral protein HBx on cell apoptosis, transformation, and tumorigenesis in association with oncoprotein. Cancer Lett. 2006; Nov 28; 244(1):119-28