个人简介
受教育经历(从大学本科开始,按时间倒排序) 1986/09-1989/07 武汉大学,化学系,学士﹑硕士 1992/12-1996/05 香港中文大学,化学系,博士 研究工作经历(按时间倒排序) 1989/07-/1992/12, 武汉大学,化学系,助教,讲师 1996/10-1998/10, 美国弗吉利亚大学,化学系,博士后 1998/11-2001/05, 美国马里兰大学,化学与生物化学系,博士后,从事小分子与核酸的识别和相互作用 2001/05-至今, 武汉大学,化学与分子科学学院,教授,博士生导师 获得学术奖励 2012年国务院政府特殊津贴获得者 2010年湖北省自然科学一等奖(排名第一) 2010年药明康德生命化学奖二等奖 2004年湖北省第十届自然科学优秀学术论文特等奖(排名第一)
研究领域
化学生物学、生物有机化学、药物化学。
近期论文
近3年主要论著 : 1.Wang, S. R., Fu, B. S., Wang, J. Q., Wang, Long, Y. L., Zhang, X. E., Peng, S., Guo, P., Tian, T.* and Zhou, X.* Novel Amplex Red Oxidases based on Non-canonical DNA Structures: Property Studies and Applications in MicroRNA Detection. Anal. Chem., 2014, DOI: 10.1021/ac402535a. 2.Wang, C., Feng, S., Wu, L., Yan, S., Zhong, C., Guo, P., Huang, R., Weng, X.* and Zhou, X.* A new fluorescent turn-on probe for highly sensitive and selective detection of sulfite and bisulfite. Sens. Actuators B Chem., 2014, 190, 792-799. 3.Wang, S., Long, Y., Wang, J., Ge, Y., Guo, P., Liu, Y., Tian, T.* and Zhou, X.* Systematic investigations of different cytosine modifications on CpG dinucleotide sequences: The effects on the B-Z transition. J. Am. Chem. Soc., 2014. 136. 56-59. 4.Tang, Y., Chu, J.-M., Huang, W., Xiong, J., Xing, X.-W., Zhou, X., Feng, Y.-Q.* and Yuan, B.-F*. Hydrophilic Material for the Selective Enrichment of 5-hydroxymethylcytosine and Its LC-MS/MS Detection. Anal. Chem., 2013, 85, 6129−6135. 5.Hong, T., Wang, T., Guo, P., Xing, X., Ding, F., Chen, Y., Wu, J., Ma, J., Wu, F. and Zhou, X.* Fluorescent Strategy Based on Cationic Conjugated Polymer Fluorescence Resonance Energy Transfer for the Quantification of 5-(Hydroxymethyl) cytosine in Genomic DNA. Anal. Chem., 2013, 85, 10797-10802. 6.Wang, C., Yan, S., Huang R., Feng S., Fu, B., Weng, X.* and Zhou, X.* A turn-on fluorescent probe for detection of tyrosinase activity. Analyst, 2013,138, 2825-2828 7.Guo, P., Yan, S., Zhou, Y., Wang C., Xu, X., Weng, X., and Zhou, X.* A novel fluorescent “Turn-Off/Turn-On” system for the detection of acid phosphatase activity. Analyst, 2013, 138, 3365-3367. 8.Tian, T., Zhang, X., Fu, B., Long, Y., Peng, S., Wang, S.*, and Zhou, X*. Systematic investigation of DNAs with modified cytosines under hot alkali treatment. ChemComm, 2013, 49, 9968-9970. 9.Tian, T., Peng, S., Xiao, H., Long, Y., Fu, B., Zhang, X., Guo, S., Wang, S.*, Zhou, X.* and Liu, S. 5-Methyldeoxycytidine enhances the substrate activity of DNA polymerase. ChemComm, 2013, 49, 10085-10087. 10. Wang, S., Fu, B., Peng, S., Zhang, X., Tian, T. * and Zhou, X.* The G-triplex DNA could function as a new variety of DNA peroxidase. ChemComm, 2013, 49, 7920-7922. 11. Hu, J., Xing, X., Xu, X., Wu, F., Guo, P., Yan, S., Xu, Z., Xu, J., Weng, X. and Zhou, X.* Selective Chemical Labelling of 5-Formylcytosine in DNA by Fluorescent Dyes. Chem. Eur. J., 2013, 19, 5836-5840.