周宇
教授 博导
个人简介
学习经历 1999 年 09 月 - 2003 年 06 月,武汉大学,本科,生物学基地班 2003 年 09 月 - 2004 年 09 月,武汉大学,硕士,生化与分子生物学 2004 年 10 月 - 2005 年 07 月,法国巴黎十一大学,硕士,生物信息与生物统计学 2005 年 09 月 - 2008 年 12 月,武汉大学,博士,生化与分子生物学 2005 年 09 月 - 2008 年 12 月,法国巴黎十一大学,博士(与武汉大学联合培养),计算机 主要工作经历及任职情况 2009 年 07 月 - 2015 年 05 月,美国加州大学圣地亚哥分校,博士后 2015 年 05 月 - 至今,武汉大学生命科学学院,教授 2015 年 08 月 - 至今,武汉大学高等研究院,兼职研究员 2019 年 04 月 - 至今,病毒学国家重点实验室,教授 2022 年 07 月 - 至今,泰康生命医学中心,教授
研究领域
生物信息与RNA生物学
近期论文
1. Peng Tang#, Jiayi Yang#, Zonggui Chen#, Chen Du, Yang Yang, Haiping Zhao, Li Huang, Guangnan Li, Feiyan Liu, Bei Dong, Ting Shan, Xichen Bao, Yu Zhou*. Nuclear retention coupled with sequential polyadenylation dictates post-transcriptional m6A modification in the nucleus, Molecular Cell, 2024, 84, DOI: 10.1016/j.molcel.2024.07.017. 2. Xinghai Yu#, Jinghua Zhou#, Wenkai Ye#, Jingxiu Xu, Rui Li, Li Huang, Yi Chai, Miaomiao Wen, Suhong Xu*, Yu Zhou*. Time-course swRNA-seq uncovers a hierarchical gene regulatory network in controlling the response-repair-remodeling after wounding, Communications Biology 2024, 7: 694. 3. Ting Shan#, Feiyan Liu#, Miaomiao Wen#, Zonggui Chen, Shaopeng Li, Yafen Wang, Hong Cheng, Yu Zhou*. m6A modification negatively regulates translation by switching mRNA from polysome to P-body via IGF2BP3. Molecular Cell, 2023, 83:4494–4508. 4. Changshou Wang#, Lin Xu#, Chen Du#, Hao Yun#, KeyunWang#, Hui Liu, Mingliang Ye*, Jing Fan*, Yu Zhou*, Hong Cheng*. CDK11 requires a critical activator SAP30BP to regulate pre-mRNA splicing. The EMBO Journal, 2023, 42(24):e114051. 5. Li Huang#, Guangnan Li#, Chen Du#, Yu Jia, Jiayi Yang, Weiliang Fan, YongZhen Xu, Hong Cheng, Yu Zhou*. The polyA tail facilitates splicing of last introns with weak 3’ splice sites via PABPN1. EMBO Reports, 2023, 24:e57128. 6. Dehe Wang#, Xiao Hu#, Hanzhe Ye, Yue Wang, Qian Yang, Xiaodong Liang, Zilin Wang, Yifan Zhou, MiaomiaoWen, Xueyan Yuan, Xiaomin Zheng, Wen Ye, Boyu Guo, Mayila Yusuyin, Eugenia Russinova, Yu Zhou*, Kun Wang*. Cell-specific clock-controlled gene expression program regulates rhythmic fiber cell growth in cotton. Genome Biology, 2023, 24(1):49. 7. Guangnan Li#, Zhidong Tang#, Weiliang Fan#, Xi Wang#, Li Huang, Yu Jia, Manli Wang, Zhihong Hu, Yu Zhou*. Atlas of interactions between SARS-CoV-2 macromolecules and host proteins. Cell Insight, 2023, 2:100068. 8. Kai Wu#, Dehe Wang#, Junhao Wang, Yu Zhou*. Translation landscape of SARS-CoV-2 noncanonical subgenomic RNAs. Virologica Sinica, 2022, 37:813–822. 9. Peng Tang#, Yu Zhou*. Alternative polyadenylation regulation: insights from sequential polyadenylation. Transcription, 2022, 13:4-5:89–95. 10. Bingbing Xu#, Yanda Zhu#, Changchang Cao#, Hao Chen#, Qiongli Jin#, Guangnan Li#, Junfeng Ma#, Siwy Ling Yang#, Jieyu Zhao#, Jianghui Zhu#, Yiliang Ding*, Xianyang Fang*, Yongfeng Jin*, Chun Kit Kwok*, Aiming Ren*, Yue Wan*, Zhiye Wang*, Yuanchao Xue*, Huakun Zhang*, Qiangfeng Cliff Zhang*, Yu Zhou*. Recent advances in RNA structurome. Science China Life Sciences, 2022, 65:1285–1324. 11. Geng Chen#, Yang Yang#, Qi-Jia Wu#, Liu Cao#, Wen Ruan, Changwei Shao, Li Jiang, Peng Tang, Suping Ma, Ao Jiang, Zhen Wang, Kai Wu, Qiangfeng Cliff Zhang, Xiang-Dong Fu, Yu Zhou*. ILF3 represses repeat-derived microRNAs targeting RIG-I mediated type I interferon response. Journal of Molecular Biology, 2022, 434(7):167469. 12. Shaopeng Li#, Linmao Li#, Weiliang Fan, Suping Ma, Cheng Zhang, Jang Chol Kim, Kun Wang, Eugenia Russinova, Yuxian Zhu*, Yu Zhou*. LeafNet: a tool for segmenting and quantifying stomata and pavement cells. The Plant Cell, 2022, 34(4):1171–1188. 13. Peng Tang#, Yang Yang#, Guangnan Li, Li Huang, Miaomiao Wen, Wen Ruan, Xiaolong Guo, Chen Zhang, Xinxin Zuo, Daji Luo, Yongzhen Xu, Xiang-Dong Fu*, Yu Zhou*. Alternative polyadenylation by sequential activation of distal and proximal PolyA sites. Nature Structural & Molecular Biology, 2022, 29(1):21–31. 14. Zhidong Tang#, Weiliang Fan#, Qiming Li#, Dehe Wang, Miaomiao Wen, Junhao Wang, Xingqiao Li, Yu Zhou*. MVIP: multi-omics portal of viral infection. Nucleic Acids Research, 2022, 50(D1):D817–D827. 15. Yangyang Li#, Zonggui Chen#, Hairong Liu#, Qiming Li, Xing Lin, Shuhui Ji, Rui Li, Shaopeng Li, Weiliang Fan, Haiping Zhao, Zuoyan Zhu, Wei Hu*, Yu Zhou*, Daji Luo*. ASER: Animal Sex Reversal Database. Genomics Proteomics Bioinformatics, 2021, 19:873–881. 16. Dehe Wang#, Ao Jiang#, Jiangpeng Feng#, Guangnan Li#, Dong Guo#, Muhammad Sajid, Kai Wu, Qiuhan Zhang, Yann Ponty, Sebastian Will, Feiyan Liu, Xinghai Yu, Shaopeng Li, Qianyun Liu, Xing-Lou Yang, Ming Guo, Xingqiao Li, Mingzhou Chen, Zheng-Li Shi, Ke Lan*, Yu Chen*, Yu Zhou*. The SARS-CoV-2 subgenome landscape and its novel regulatory features. Molecular Cell, 2021, 81(10):2135–2147. 17. Xinxin Zuo#, Jie Zhou#, Yinming Li#, Kai Wu, Zonggui Chen, Zhiwei Luo, Xiaorong Zhang, Yi Liang, Miguel A. Esteban, Yu Zhou*, Xiang-Dong Fu*. TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS. Nature Structural & Molecular Biology, 2021, 28:132–142. 18. Yong Xiong#, Yuan Liu#, Liu Cao#, Dehe Wang#, Ming Guo, Ao Jiang, Dong Guo, Wenjia Hu, Jiayi Yang, Zhidong Tang, Honglong Wu, Yongquan Lin, Meiyuan Zhang, Qi Zhang, Mang Shi, Yingle Liu, Yu Zhou*, Ke Lan*, Yu Chen*. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Emerging Microbes & Infections 2020, 9, 761–770. 19. Dehe Wang#, Weiliang Fan#, Xiaolong Guo#, Kai Wu, Siyu Zhou, Zonggui Chen, Danyang Li, Kun Wang*, Yuxian Zhu*, Yu Zhou*. MaGenDB: a functional genomics hub for Malvaceae plants. Nucleic Acids Research, 2020, 48: D1076-D1084. 20. Peng Dai#, Xin Wang#, Lan-Tao Gou#, Zhi-Tong Li#, Ze Wen#, Zong-Gui Chen#, Min-Min Hua, Ai Zhong, Lingbo Wang, Haiyang Su, Huida Wan, Kun Qian, Lujian Liao, Jinsong Li, Bin Tian, Dangsheng Li, Xiang-Dong Fu, Hui-Juan Shi*, Yu Zhou*, Mo-Fang Liu*. A Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis. Cell, 2019, 179:1566-1581. 21. Kun Wang#, Dehe Wang#, Xiaomin Zheng, Ai Qin, Jie Zhou, Boyu Guo, Yanjun Chen, Xingpeng Wen, Wen Ye, Yu Zhou*, Yuxian Zhu*. Multi-strategic RNA-seq analysis reveals a high-resolution transcriptional landscape in cotton. Nature Communications, 2019, 10:4714. 22. Jianshu Wang#, Jiyun Chen#, Guifen Wu#, Hongling Zhang#, Xian Du#, Suli Chen, Li Zhang, Ke Wang, Jing Fan, Shuaixin Gao, Xudong Wu, Shouxiang Zhang, Bin Kuai, Peng Zhao, Binkai Chi, Lantian Wang, Guohui Li, Catherine C.L. Wong, Yu Zhou*, Jinsong Li*, Caihong Yun*, Hong Cheng*. NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction. Genes & Development, 2019, 33:536-549. 23. Kai Zhang#, Xiaorong Zhang#, Zhiqiang Cai#, Jie Zhou#, Ran Cao, Ya Zhao, Zonggui Chen, Dehe Wang, Wen Ruan, Qian Zhao, Guangqiao Liu, Yuanchao Xue, Yan Qin, Bing Zhou, Ligang Wu, Timothy Nilsen, Yu Zhou*, Xiang-Dong Fu*. A novel class of microRNA-recognition elements that function only within open reading frames. Nature Structural & Molecular Biology, 2018, 25(11):1019-1027. 24. Jiaqi Gu#, Ming Wang#, Yang Yang#, Ding Qiu, Yiqun Zhang, Jinbiao Ma*, Yu Zhou*, Gregory J. Hannon*, Yang Yu*. GoldCLIP: Gel-omitted Ligation-dependent CLIP. Genomics, Proteomics & Bioinformatics, 2018, 16(2):136-143. 25. Li Jiang#, Changwei Shao#, Qi-Jia Wu#, Geng Chen, Jie Zhou, Bo Yang, Hairi Li, Lan-Tao Gou, Yi Zhang, Yangming Wang, Gene W Yeo, Yu Zhou*, Xiang-Dong Fu*. NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing. Nature Structural & Molecular Biology, 2017, 24:816-824. 26. Huiwu Ouyang, Kai Zhang, Kristi Fox-Walsh, Yang Yang, Chen Zhang, Jie Huang, Hairi Li, Yu Zhou*, Xiang-Dong Fu*. The RNA binding protein EWS is broadly involved in the regulation of pri-miRNA processing in mammalian cells. Nucleic Acids Research, 2017, 45(21):12481-12495. 27. Chaoliang Wei#, Rui Xiao#, Liang Chen#, Hanwei Cui#, Yu Zhou#, Yuanchao Xue, Jing Hu, Bing Zhou, Taiki Tsutsui, Jinsong Qiu, Hairi Li, Liling Tang, Xiang-Dong Fu*. RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes. Molecular Cell, 2016, 62(6):875-889. 28. Lanfeng Wang#, Yu Zhou#, Liang Xu#, Rui Xiao#, Xingyu Lu, Liang Chen, Jenny Chong, Hairi Li, Chuan He, Xiang-Dong Fu*, Dong Wang*. Molecular Basis for 5-Carboxycytosine Recognition by RNA Polymerase II Elongation Complex. Nature, 2015, 523:621–625. 29. Yu Zhou#, Hai-Ri Li, Jie Huang, Ge Jin, Xiang-Dong Fu*. Multiplex analysis of polyA-linked sequences (MAPS): an RNA-seq strategy to profile poly(A+) RNA. Methods Mol Biol, 2014, 1125:169-178. 30. Shatakshi Pandit#, Yu Zhou#, Lily Shiue#, Gabriela Coutinho-Mansfield, Hairi Li, Jinsong Qiu, Jie Huang, Gene W. Yeo, Manuel Ares, Jr.*, Xiang-Dong Fu*. Genome-wide analysis reveals SR protein cooperation and competition in regulated splicing. Molecular Cell, 2013, 50(2):223-235.