学习简历 2002 年 9 月 - 2006 年 7 月，就读于四川大学化学学院，获得学士学位。 2006 年 9 月 - 2011 年 6 月，在四川大学化学学院深造，获得博士学位。 工作经历 2011 年 7 月 - 2013 年 6 月，于新加坡南洋理工大学从事博士后研究工作。 2013 年 6 月 - 至今，担任武汉大学药学院副教授。

1. 肿瘤诊疗药物的设计，开发智能的19F MRI可视化药物载体，并将其应用于肿瘤等重大疾病的诊断、治疗以及药物传递系统的监测 2. 含氟药物、含氟功能材料的高效合成及生物活性研究

药物化学、药物材料

(1) Qianying Zhou, Mi Huang, Yongcun Shen, Zhenling Chen,* Liying Xu, and Zhigang Yang*, “Synthesis of gem-Difluorinated 2,3-Dihydrobenzofurans Using Freon-22 via [4+1] Annulation of Difluorocarbene and Antitumor Activity Evaluation” Org. Lett. 2024, 26, 1212−1217. (2) Yuyin Mao, Na Li, Jie Liu,* Zhong-Xing Jiang, and Zhigang Yang*, “TBAF-Mediated [3+1] Cycloaddition of Difluorocarbene to Access gem-Difluorinated 1,2-Diazetidine Analogues as Potent Anticancer Agents” Org. Lett. 2023, 25, 7567−7572. (3) Xiangyu Li, Na Li, Lan Yang, Rui Jiang, Yong He, Jian Shi, Zhong-Xing Jiang, and Zhigang Yang*, “Switchable Nucleophilic Site Enables Expedient Synthesis of CF3‑Containing Thiazoles and Allenes from 1,3-Enynes” ACS Catal. 2023, 13, 12755−12765. (4) Yushan Xiao, Yimin Jia, Jinfeng Huang, Xiangyu Li, Zhiwen Zhou, Jing Zhang, Mou Jiang, Xin Zhou, Zhong-Xing Jiang*, and Zhigang Yang*, “Synthesis of SCF3-Substituted Sulfonium Ylides from Sulfonium Salts or α-Bromoacetic Esters” Adv. Synth. Catal. 2022, 364, 738−743. (5) Yimin Jia, Yuan Yuan, Jinfeng Huang, Zhong-Xing Jiang*, and Zhigang Yang*, “Synthesis of Difluorinated Heterocyclics through Metal-Free [8+1] and [4+1] Cycloaddition of Difluorocarbene” Org. Lett. 2021, 23, 2670−2675. (6) Jinfeng Huang, Yimin Jia, Xiangyu Li, Jianli Duan, Zhong-Xing Jiang, and Zhigang Yang*, “Halotrifluoromethylation of 1,3-Enynes: Access to Tetrasubstituted Allenes” Org. Lett. 2021, 23, 2314−2319. (7) Na Wang, Yimin Jia, Hongmei Qin, Zhong-xing Jiang, and Zhigang Yang*, “Chlorotrifluoromethylthiolation of Sulfur Ylides for the Formation of Tetrasubstituted Trifluoromethylthiolated Alkenes” Org. Lett. 2020, 22, 7378−7382. (8) Ying Zheng, Yimin Jia, Yuan Yuan, Zhong-Xing Jiang,* and Zhigang Yang*, “F- −Free Deoxyhydrotrifluoromethylation of α-Keto Esters with Ph3P+CF2CO2-: Synthesis of α-CF3‑Substituted Esters” J. Org. Chem. 2020, 85, 10913−10923. (9) Hongmei Qin, Yimin Jia, Na Wang, Zhong-Xing Jiang and Zhigang Yang*, “Practical and regioselective halo-trifluoromethylthiolation of sulfur ylides” Chem. Commun. 2020, 56, 8265−8268. (10) Jing Zhang, Yuan Yuan, Yu Li, Hao Yang, Huaibin Zhang, Shizhen Chen, Xin Zhou, Zhigang Yang*, and Zhong-Xing Jiang*, “Synthesis of Branched Monodisperse Oligoethylene Glycols and 19F MRI-Traceable Biomaterials through Reductive Dimerization of Azides” J. Org. Chem. 2020, 85, 6778−6787. (11) Yimin Jia, Long Chen, Huaibin Zhang, Ying Zheng, Zhong-Xing Jiang and Zhigang Yang*, “Electrophilic chloro(ω-alkoxy)lation of alkenes employing 1-chloro-1,2-benziodoxol-3-one: facile synthesis of β-chloroethers” Org. Biomol. Chem. 2018, 16, 7203−7213. (12) Yimin Jia, Hongmei Qin, Na Wang, Zhong-Xing Jiang, and Zhigang Yang*, “Fe2O3‑promoted intermolecular chlorotrifluoromethylthiolation of alkenes” J. Org. Chem. 2018, 83, 2808−2817. (13) Haotian Xing, Long Chen, Yimin Jia, Zhongxing Jiang*, Zhigang Yang*, “Fe2O3-catalyzed Pummerer Rearrangement of Acyl Chlorides and Sulfoxides: Facile Synthesis of Alkylthiomethyl Ester” Tetrahedron Lett. 2017, 58, 2199−2202. (14) Zihong Wan, Yu Li, Shaowei Bo, Ming Gao, Xuemeng Wang, Kai Zeng, Xin Tao, Xuefei Li, Zhigang Yang*, and Zhong-Xing Jiang*, “Amide bond-containing monodisperse polyethylene glycols beyond 10 000 Da” Org. Biomol. Chem. 2016, 14, 7912−7919. (15) Long Chen, Haotian Xing, Huaibin Zhang, Zhong-Xing Jiang* and Zhigang Yang*, “Copper-catalyzed intermolecular chloroazidation of α,β-unsaturated amides” Org. Biomol. Chem. 2016, 14, 7463−7467. (16) Mingyang Fu, Long Chen, Yongpeng Jiang, Zhong-Xing Jiang,* and Zhigang Yang*, “Copper-Catalyzed Intermolecular Chloro- and Bromotrifluoromethylation of Alkenes” Org. Lett. 2016, 18, 348−351. (17) Guiquan Xia, Yu Li, Zhigang Yang*, and Zhong-Xing Jiang*, “Development of a Scalable Process for α-Amino-ω-methoxyl-dodecaethylene Glycol” Org. Process Res. Dev. 2015, 19, 1769−1773. (18) Yu Li, Qi Guo, Xuefei Li, Hua Zhang, Fanghua Yu, Weijiang Yu, Guiquan Xia, Mingyang Fu, Zhigang Yang*, Zhong-Xing Jiang*, “Fluorous synthesis of mono-dispersed poly(ethylene glycols)” Tetrahedron Lett. 2014, 55, 2110−2113. (19) Zhigang Yang and Jianrong (Steve) Zhou*, “Palladium-Catalyzed, Asymmetric Mizoroki-Heck Reaction of Benzylic Electrophiles Using Phosphoramidites as Chiral Ligands” J. Am. Chem. Soc. 2012, 134, 11833−11835. (20) Zhigang Yang, Zhen Wang, Sha Bai, Xiaohua Liu, Lili Lin, Xiaoming Feng*, “Asymmetric α-Amination of 4-Substituted Pyrazolones Catalyzed by a Chiral Gd(OTf)3/N,N′-Dioxide Complex: Highly Enantioselective Synthesis of 4-Amino-5-pyrazolone Derivatives” Org. Lett. 2011, 13, 596−599. (21) Zhigang Yang, Zhen Wang, Sha Bai, Ke Shen, Donghui Chen, Xiaohua Liu, Lili Lin, Xiaoming Feng*, “Highly Enantioselective Synthesis of 3-Amino-2-oxindole Derivatives: Catalytic Asymmetric α-Amination of 3-Substituted 2-Oxindoles with a Chiral Scandium Complex” Chem. Eur. J. 2010, 16, 6632−6637. (22) Zhigang Yang, Jie Liu, Xiaohua Liu, Zhen Wang, Xiaoming Feng*, Zhishan Su, Changwei Hu*, “Highly Efficient Amine Organocatalysts Based on Bispidine for the Asymmetric Michael Addition of Ketones to Nitroolefins” Adv. Synth. Catal. 2008, 350, 2001−2006.