学习经历 1992.09 - 1995.07，湖北工程学院（原孝感师专）生物系，专科 2001.09 - 2006.12，武汉大学生命科学学院，遗传学专业，硕博连读 主要工作经历与任职 1995.09 - 1999.07，武钢九中，生物教师 2006.12 - 2010.12，武汉大学基础医学院，讲师 2010.09 - 2011.09，湖北省随州市卫生局，副局长 2011.01 - 至今，武汉大学基础医学院，副教授 2014.01 - 2015.02，美国克利夫兰医学中心，访问学者

遗传病基因突变的功能研究； 基因诊断的新方法研究； 肝癌的分子机制与药物发现。

(1) Yuqing Su，Juntao Zhang，Jiahui Gao, Guoqing Ding, Heng Jiang, Yang Liu, Yulei Li, Guohua Yang. Truncated FRMD7 Proteins in Congenital Nystagmus: Novel Frameshift Mutations and Proteasomal Pathway Implications. BMC Medical Genomics. 2024, doi: 10.1186/s12920-024-01817-7（通讯作者） (2) Guangjie Zhan, Tiantian Wei, Huichen Xie, Xiaoming Xie, Jun Hu, Hao Tang, Yating Cheng, Huaifeng Liu, Shujing Li, Guohua Yang. Autophagy inhibition mediated by trillin promotes apoptosis in hepatocellular carcinoma cells via activation of mTOR/STAT3 signaling. Naunyn Schmiedebergs Arch Pharmacol. 2023, doi: 10.1007/s00210-023-02700-5.（通讯作者） (3) Weikang Hu, Zesheng Chen, Xi Chen, Kexin Feng, Tao Hu, Bohan Huang, Jinlan Tang, Guanyi Wang, Shiyu Liu, Guohua Yang, Zijian Wang. Double-network cellulose-based hybrid hydrogels with favourable biocompatibility and antibacterial activity for wound healing. Carbohydr Polym. 2023, doi: 10.1016 /j.carbpol.2023.121193.（共同通讯） (4) Ronghong Xiong , Hui Wang , Ying Li , Jingpeng Zheng , Yating Cheng , Shunfang Liu and Guohua Yang, Machine learning-based transcriptome analysis of lipid metabolism biomarkers for the survival prediction in hepatocellular carcinoma. Frontiers in Genetics, 2022, DOI: 10.3389/fgene.2022.1005271（通讯作者） (5) Xin Chen# , Guohua Yang#, Xiaohong Guo, Jing Zhang, Wei Sun, Dongbo Liu, Hui Wang, Shunfang Liu. DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinom. Oxidative Medicine and Cellular Longevity. 2022, Article ID 2543220, 20 pages. https://doi.org/10.1155/2022/2543220.（并列第一） (6) Xianggang Wang #, Guohua Yang #, Qingqing Wang, Yilong Zhao, Kaixin Ding, Can Ji, Zongyuan Shi, Huaying Li, Ying Li, Shujing Li. C1R, CL2, and TNFRSF1A Genes in Coronavirus Disease-COVID-19 Pathway Serve as Novel Molecular Biomarkers of GBM Prognosis and Immune Infiltration. Dis Markers. 2022, doi: 10.1155/2022/8602068. PMID: 35726234（并列第一） (7) Xiao-Hong Guo, Shui-Shan Jiang, Li-Li Zhang, Jun Hu, Dilda Edelbek, Yu-Qi Feng, Zi-Xian Yang, Peng-Chao Hu, Hua Zhong, Guo-Hua Yang*, Fang Yang*. Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway. Oncol Rep. 2021;46(6):253. doi: 10.3892/or.2021.8204.（共同通讯） (8) Hua Zhong†, Shuai Liu†, Fang Cao†, Yi Zhao, Jianguo Zhou, Feng Tang, Zhaohua Peng, Yangsheng Li, Shen Xu, Chunlin Wang*, Guohua Yang*and Zhi-Qiang Li*. Dissecting Tumor Antigens and Immune Subtypes of Glioma to Develop mRNA Vaccine. Frontiers in Immunology. 2021(12), Article 709986, doi: 10.3389/fimmu.2021.709986.（共同通讯） (9) Cong Qiu, Chengyan Li, Xiaoyun Tong, Luoyang Dai, Wenda Liu, Yulie Xie, Qimei Zhang, Guohua Yang*, Tao Li*. A novel TSC1 frameshift mutation c.1550_1551del causes tuberous sclerosis complex by aberrant splicing and nonsense-mediated mRNA degradation (NMD) simultaneously in a Chinese family. Mol Genet Genomic Med. 2020; e1410. doi: 10.1002/mgg3.1410.（共同通讯） (10) Guangjie Zhan, Jun Hu#, Benjian Xiao, Xianli Wang, Zixian Yang, Guohua Yang*, Lili Lu*. Trillin prevents proliferation and induces apoptosis through inhibiting STAT3 nuclear translocation in hepatoma carcinama cells. Medical Oncology, 2020, 37(5): 44. doi: 10.1007/s12032-020-01369-7.（共同通讯） (11) Siying He, Hui Sun, Yifang Huang, Shiqi Dong, Chen Qiao, Shuai Zhang, Chen Wang, Fang Zheng, Ming Yan*, Guohua Yang*. Identification and Interaction Analysis of Significant Genes and MicroRNAs in Pterygium. BioMed Research International. 2019, Article ID 2767512, 12 pages. doi: 10.1155/2019/2767512. （通讯作者）