6、学习经历： 2010.07 -2012.06 武汉大学，生命科学学院发育生物学，博士后 2007.09 -2010.06 武汉大学，基础医学院药理学系，博士 2005.09-2007.06 武汉大学，基础医学院药理学系，硕士 2000.09-2005.06 武汉大学，医学院临床医学专业，学士 7、主要工作经历与任职： 2013.01-至今 武汉大学，基础医学院药理学系，副教授 2016.01-2017.01 美国匹兹堡大学，遗传药理中心，访问学者 2011.01 -2012.12 武汉大学，基础医学院药理学系，讲师 2010.07-2010.12 武汉大学，基础医学院药理学系，助教

专注于胎源性疾病的宫内编程机制及药物防治研究。前期研究系统证实了孕期地塞米松、尼古丁、咖啡因暴露所致宫内发育迟缓（IUGR）子代成年下丘脑-垂体-肾上腺（HPA）轴相关疾病（如脂肪肝、高胆固醇血症、躁郁症、学习记忆障碍、卵巢早衰）易感的胎儿起源现象，创新性提出宫内神经内分泌代谢编程改变是引起IUGR仔鼠成年HPA轴相关疾病易感的胎儿起源机制。

1) Xu D, Luo HW, Hu W, Hu SW, Yuan C, Wang GH, Zhang L, Yu H, Magdalou J, Chen LB, Wang H. Intrauterine programming mechanism for hypercholesterolemia in prenatal caffeine-exposed female adult rat offspring. FASEB J. 2018;32(10):5563-5576. 2) Lu J, Jiao Z, Yu Y, Zhang C, He X, Li Q, Xu D*, Wang H*. Programming for increased expression of hippocampal GAD67 mediated the hypersensitivity of the hypothalamic-pituitary-adrenal axis in male offspring rats with prenatal ethanol exposure. Cell Death Dis. 2018;31;9(6):659. 3) Lv F, Wan Y, Chen YX, Pei LG, Luo DJ, Fan GL, Luo MC, Xu D*, Wang H*. Prenatal dexamethasone exposure induced ovarian developmental toxicity and a transgenerational inheritance effect in rat offspring. Endocrinology. 2018;159(3):1401-1415. 4) He B, Xu D*, Zhang C, Zhang L, Wang H*. Prenatal food restriction induces neurobehavioral abnormalities in adult female offspring rats and alters intrauterine programming. Toxicol Res. 2018;7(2):293-306. 5) Xu D*, Zhang C, He X, Guo ZJ, Hu DC, Lu J, Cheng SY, Wang H*. High expression of hippocampal glutamic acid decarboxylase 67 mediates hypersensitivity of the hypothalamic-pituitary-adrenal axis in response to prenatal caffeine exposure in rats. Toxicol Lett. 2018;283:39-51. 6) Dong WT, Xu D*, Hu ZW, He X, Guo ZJ, Jiao ZX, Yu Y, Wang H. Low-functional programming of the CREB/BDNF/TrkB pathway mediates cognitive impairment in male offspring after prenatal dexamethasone exposure. Toxicol Lett. 2018;283:1-12. 7) He X, Lu J, Dong WT, Jiao ZX, Zhang C, Yu Y, Zhang ZH, Wang H, Xu D*. Prenatal nicotine exposure induces HPA axis-hypersensitivity in offspring rats via the intrauterine programming of up-regulation of hippocampal GAD67. Arch Toxicol. 2017;91(12):3927-3943. 8) Lu J, Wen YX, Zhang L, Zhang C, Zhong WH, Zhang L, Yu Ying, Chen LB, Xu D*, Wang H*. Prenatal ethanol exposure induces an intrauterine programming of enhanced sensitivity of the hypothalamic-pituitary-adrenal axis in female offspring rats fed with post-weaning high-fat diet. Toxicol Res. 2015;4(5):1238-1249. 9) Xu D, Bai J, Zhang L, Shen L, Wang LL, Liu ZF, Xia LP, Wang H. Prenatal nicotine exposure-induced intrauterine programming alteration increases the susceptibility of high-fat diet-induced non-alcoholic simple fatty liver in female adult offspring rats. Toxicol Res. 2015; 4(1):112-120. 10) Zhang C, Xu D, Luo H, Lu J, Liu L, Ping J, Wang H. Prenatal xenobiotic exposure and intrauterine hypothalamus-pituitary-adrenal axis programming alteration. Toxicology. 2014;325C:74-84.