学习经历 - 2001.9 - 2005.7，武汉大学生命科学学院，生物技术专业，本科 - 2005.9 - 2008.7，中国科学院武汉病毒研究所，生物技术与分子生物学专业，硕士，导师：胡志红研究员、邓菲研究员 - 2008.9 - 2013.9，德国慕尼黑工业大学，医学生命科学技术专业，博士，导师：Ulrike Protzer教授 主要工作经历与任职 - 2013.9 - 2014.9，德国环境健康研究中心，博士后，导师：Ulrike Protzer教授 - 2014.10 - 2018.9，国立糖尿病消化及肾脏疾病研究所，美国国立卫生研究院，博士后，导师：Dr. T.Jake Liang - 2018.10 - 至今，病毒学国家重点实验室、基础医学院，武汉大学，教授、博导

1. 乙肝病毒与宿主相互作用机制； 2. 乙肝病毒致癌机制及靶向治疗； 3. 新型抗病毒药物筛选及机制研究；4. 干细胞精准医疗用于晚期肝病研究。

1. Zheng Y, Wang M, Li S, Bu Y, Xu Z, Zhu G, Wu C, Zhao K, Li A, Chen Q, Wang J, Hua R, Teng Y, Zhao L, Cheng X, Xia Y*. Hepatitis B virus hijacks TSG101 to facilitate egress via multiple vesicle bodies. PLoS Pathogens. 2023 May 24;19(5):e1011382. 2. Yi J, Lei X, Guo F, Chen Q, Chen X, Zhao K, Zhu C, Cheng X, Lin J*, Yin H*, Xia Y*. Co-delivery of Cas9 mRNA and guide RNAs edits hepatitis B virus episomal and integration DNA in mouse and tree shrew models. Antiviral Research. 2023 Jul;215:105618. 3. Li A, Zhang B, Zhao K, Yin Z, Teng Y, Zhang L, Xu Z, Liang K, Cheng X*, Xia Y*. SARS-CoV-2 nsp13 Restricts Episomal DNA Transcription without Affecting Chromosomal DNA. Journal of Virology. 2023 Jun 22:e0051223. 4. Zhao K, Guo F, Wang J, Zhong Y, Yi J, Teng Y, Xu Z, Zhao L, Li A, Wang Z, Chen X, Cheng X, Xia Y*. Limited disassembly of cytoplasmic hepatitis B virus nucleocapsids restricts viral infection in murine hepatic cells. Hepatology. 2023 Apr 1;77(4):1366-1381. 5. Zhong Y, Wu C, Xu Z, Teng Y, Zhao L, Zhao K, Wang J, Wang W, Zhan Q, Zhu C, Chen X, Liang K, Cheng X, Xia Y*. Hepatitis B Virus Core Protein Is Not Required for Covalently Closed Circular DNA Transcriptional Regulation. Journal of Virology. 2022 Nov 9;96(21):e0136222. 6. Xu Z, Zhao L, Zhong Y, Zhu C, Zhao K, Teng Y, Cheng X, Chen Q, Xia Y*. A Novel Mouse Model Harboring Hepatitis B Virus Covalently Closed Circular DNA. Cell Mol Gastroenterol Hepatol. 2022;13(4):1001-1017. 7. Teng Y, Xu Z, Zhao K, Zhong Y, Wang J, Zhao L, Zheng Z, Hou W, Zhu C, Chen X, Protzer U, Li Y*, Xia Y*. Novel function of SART1 in HNF4α transcriptional regulation contributes to its antiviral role during HBV infection. Journal of Hepatology. 2021 Nov;75(5):1072-1082. 8. Li A, Zhao K, Zhang B, Hua R, Fang Y, Jiang W, Zhang J, Hui L, Zheng Y, Li Y, Zhu C, Wang PH, Peng K, Xia Y*. SARS-CoV-2 NSP12 Protein Is Not an Interferon-β Antagonist. Journal of Virology. 2021 Aug 10;95(17):e0074721. doi: 10.1128/JVI.00747-21. 9. Liu R, Zhao L, Cheng X, Huan H, Li C, Li D, Liu A, Gao G, Zhou F, Liu F, Jiang Y*, Zhu C*, Xia Y*. Clinical Characteristics of COVID-19 Patients with Hepatitis B Virus Infection - a Retrospective Study. Liver International. 2021 Apr;41(4):720-730. doi: 10.1111/liv.14774.(封面文章，ESI高被引) 10. Han H, Ma Q, Li C, Liu R, Zhao L, Wang W, Zhang P, Liu X, Gao G, Liu F, Jiang Y, Cheng X, Zhu C*, Xia Y*. Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors. Emerging Microbes & Infection. 2020 Dec;9(1):1123-1130.（ESI高被引） 11. Xia Y, Liang TJ. Development of Direct-acting Antiviral and Host-targeting Agents for Treatment of HBV Infection. Gastroenterology. 2019 Jan;156(2):311-324.（ESI高被引） 12. Xia Y, Carpentier A, Cheng X, Block PD, Zhao Y, Zhang Z, Protzer U, Liang TJ. Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions. Journal of Hepatology. 2017 Mar;66(3):494-503. 13. Xia Y#, Stadler D#, Lucifora J, Reisinger F, Webb D, Hösel M, Michler T, Wisskirchen K, Cheng X, Zhang K, Chou WM, Wettengel JM, Malo A, Bohne F, Hoffmann D, Eyer F, Thimme R, Falk CS, Thasler WE, Heikenwalder M, Protzer U. Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis. Gastroenterology. 2016 Jan;150(1):194-205.（ESI高被引） 14. Lucifora J#, Xia Y#, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science. 2014 Mar 14;343(6176):1221-8.（ESI高被引）