学习经历 本科：1998 年 09 月 - 2002 年 07 月，就读于武汉大学化学与分子科学学院国家化学人才培养基地班，获理学学士学位。其中，2001 年 09 月 - 2002 年 06 月在中国科学院北京化学所进行联合培养。 博士：2002 年 09 月 - 2007 年 07 月，在武汉大学化学与分子科学学院攻读，获理学博士学位。期间，2006 年 04 月 - 2007 年 01 月于香港浸会大学理学院化学系开展联合研究。 工作经历 2007 年 07 月 - 2009 年 11 月，担任武汉大学药学院讲师。 2009 年 12 月 - 2022 年 11 月，任武汉大学药学院副教授。 2014 年 08 月 - 2016 年 11 月，在美国芝加哥大学从事博士后研究工作，合作导师为何川教授。 2022 年 12 月 - 至今，担任武汉大学药学院教授。

电化学纳米生物传感器的制备与应用； 核酸甲基化的检测及相关蛋白酶的活性分析； 药物与生物大分子相互作用研究； 药物色谱分离与电化学检测联用。

代表性论文： Ying Cheng#, Chen Chen#, Fang Wang*, Zilin Chen*. A highly sensitive signal-on biosensor based on restriction enzyme-mediated molecular switch for detection of TET1. Bioelectrochemistry, 2023, 152: 108433. Mei Zhao#, Guangrong Zou#, Jing Tang, Jingyi Guo, Fang Wang*, Zilin Chen*. Probe-labeled electrochemical approach for highly selective detection of 5-carboxycytosine in DNA. Analytica Chimica Acta, 2023, 1273: 341521. Hongmei Yang#, Jing Ren#, Mei Zhao, Chen Chen, Fang Wang*, Zilin Chen*. Novel electrochemical immunosensor for O6-methylguanine-DNA methyltransferase gene methylation based on graphene oxide-magnetic nanoparticles-β-cyclodextrin nanocomposite. Bioelectrochemistry, 2022, 146: 108111. Tingting Zhang#, Xiaoyan Liao#, Jing Ren#, Chen Chen, Yuying Wan, Fang Wang*, Zilin Chen*. Construction of ERGO film modified electrode and its combination with HPLC in determination of five active components in Osmanthus fragrans fruits. Chinese Journal of Analytical Chemistry, 2022, 50: 100109. Jing Tang#, Guangrong Zou#, Chen Chen, Jing Ren, Fang Wang*, Zilin Chen*. Highly selective electrochemical detection of 5Formyluracil relying on (2-Benzimidazolyl) acetonitrile labeling. Analytical Chemistry, 2021, 93: 16439–16446 (journal’s cover). Ying Cheng, Jing Tang, Xue Chen, Fang Wang*, Zilin Chen*. Assay for TET1 activity and its inhibitors screening with signal amplification by nanoparticles and Ru(III) redox recycling. Journal of Pharmaceutical and Biomedical Analysis. 2021, 203: 114228. Xue Chen#, Ying Cheng#, Yafen Wang, Fang Wang*, Zilin Chen*. Fluorescence assay based on thioflavin T-induced conformation switch of G-quadruplex for TET1 detection. Analyst, 2021, 146: 2126-2130 (journal’s cover). Zhenya Yu#, Xue Chen#, Ying Cheng, Hongmei Yang, Fang Wang*, Zilin Chen*. Novel label-free electrochemical strategy for sensitive determination of ten-eleven translocation protein 1. Analytica Chimica Acta, 2021, 1146: 140-145. Hongmei Yang#, Peiyu Hu#, Jing Tang, Ying Cheng, Fang Wang*, Zilin Chen*. A bifunctional electrochemical aptasensor based on AuNPs-coated ERGO nanosheets for sensitive detection of adenosine and thrombin. Journal of Solid State Electrochemistry, 2021, 25: 1383-1391. Hongmei Yang#, Yafen Wang#, Jing Tang, Fang Wang*, Zilin Chen*. End-labeling-based electrochemical strategy for detection of adenine methylation in nucleic acid. Microchimica Acta, 2021, 188: 250. Wei Li, Hongmei Yang, Yafen Wang, Xiaocheng Weng*, Fang Wang*. Highly sensitive detection of 6mA at single-base resolution based on A–C mismatch. Analyst, 2021, 146: 4450-4453. Xiaocheng Weng#, Jing Gong#, Yi Chen#, Tong Wu#, Fang Wang, Shixi Yang, Yushu Yuan, Guanzheng Luo, Kai Chen, Lulu Hu, Honghui Ma, Pingluan Wang, Qiangfeng Cliff Zhang*, Xiang Zhou*, Chuan He*. Keth-seq for transcriptome-wide RNA structure mapping. Nature Chemical Biology, 2020, 16: 489-492. Wei Li, Weiwu Zeng, Yi Chen, Fang Wang, Fan Wu, Xiaocheng Weng*, Xiang Zhou*. Biotinylation and isolation of an RNA G-quadruplex based on its peroxidase-mimicking activity. Analyst, 2019, 144: 4472-4476. Yi Chen, Shixi Yang, Shuang Peng, Wei Li, Fan Wu, Qian Yao, Fang Wang, Xiaocheng Weng*, Xiang Zhou*. N1-Methyladenosine detection with CRISPR-Cas13a/C2c2. Chemical Science, 2019, 10: 2975-2979. Guanzheng Luo#, Fang Wang#, Xiaocheng Weng, Kai Chen, Ziyang Hao, Miao Yu, Xin Deng, Jianzhao Liu, Chuan He, Characterization of eukaryotic DNA N6-methyladenine by a highly sensitive restriction enzyme-assisted sequencing. Nature Communications, 2016, 7, 11301 (co-first author). Lili Wang, Feiyue Yu, Fang Wang*, Zilin Chen*, Electrochemical detection of DNA methylation using a glassy carbon electrode modified with a composite made from carbon nanotubes and beta-cyclodextrin. Journal of Solid State Electrochemistry, 2016, 20(5): 1263-1270. Lili Wang, Wencheng Gong, Fang Wang*, Zhenya Yu, Zilin Chen*, Efficient bienzyme nanocomposite film for chiral recognition of L-tryptophan, L-phenylalanine and L-tyrosine. Analytical Methods, 2016, 8(17): 3481-3487. Fang Wang*, Wencheng Gong, Lili Wang, Zilin Chen*, Selective recognition of D-tryptophan from d/l-tryptophan mixtures in the presence of Cu(II) by electropolymerized L-lysine film. Analytical Biochemistry, 2016, 492: 30-33. Fang Wang*, Fangfang Yan, Yuling Long, Lili Wang, Zilin Chen*, Interaction with Deoxyribonucleic Acid and Determination of Orientin in Lophatherum gracile Brongn by High-Performance Liquid Chromatography with Amperometric Detection. Electrochimica Acta, 2015, 178: 829-837. Fang Wang*, Wencheng Gong, Lili Wang, Zilin Chen*, Enhanced amperometric response of a glucose oxidase and horseradish peroxidase based bienzyme glucose biosensor modified with a film of polymerized toluidine blue containing reduced graphene oxide. Microchimica Acta, 2015, 182(11-12): 1949-1956. Fang Wang, Xianping Sun, Yan Chen, ShijingXie, Zilin Chen*, Non-Enzymatic Glucose Sensor Based on Copper Nanoparticles Modified Microelectrode. Nanoscience and Nanotechnology Letters, 2013, 5(6): 624-629. Fangfang Yan, Fang Wang*, Zilin Chen*, Aptamer-based electrochemical biosensor for label-free voltammetric detection of thrombin and adenosine. Sensors and Actuators B-Chemical, 2011, 160(1): 1380-1385. Fang Wang, Xiaocui Deng, Wei Wang, Zilin Chen*, Nitric oxide measurement in biological and pharmaceutical samples by an electrochemical sensor. Journal of Solid State Electrochemistry, 2011, 15(4): 829-836. Fang Wang, Xiaowei Chen, Zilin Chen*, Eletrodeposited nickel oxide on a film of carbon nanotubes for monitoring nitric oxide release from rat kidney and drug samples. Microchimica Acta, 2011, 173(1-2): 65-72. Fang Wang, Yaqian Liao, Yi Ren, Zilin Chen*, A novel method for D-arabinitol determination based on a nano-structured sensing film by one-step electrodeposition. Microchimica Acta, 2010, 170:9–15