教育背景： 1981.9 - 1986.7，湖北医学院医学系，医学学士 1988.9 - 1991.7，湖北医科大学药理学，医学硕士 1996.9 - 1999.6，湖北医科大学内科学肝脏药理学，医学博士 2004.4 - 2004.7，国家教育行政学院中青班学习 工作经历： 1986.7 - 1988.8，武汉市第三医院内科，住院医师 1991.6 - 1993.5，湖北医科大学药理教研室，助教 1993.6 - 1996.12，湖北医科大学药理教研室，讲师 1997.1 - 2000.3，湖北医科大学药理教研室，副教授 2000.4 - 2012.12，武汉大学基础医学院药理学系，教授、博导、系主任、副院长 2012.12 - 2021.10，武汉大学基础医学院药理学系，二级教授、博导、系主任、省重点实验室主任 2012.12 - 2022.8，武汉大学基础医学院药理学系，二级教授、博导、省重点实验室主任 获奖荣誉： 1998 年，获霍英东教育基金会第六届全国高等院校青年教师 (教学类) 三等奖 1999 年，获湖北省高等学校科技创新与成果转化推广表彰 2000 年，获中国药理学会 Servier 全国青年药理学工作者光荣称号 2001 年，获宝钢教育基金全国优秀教师奖 2001 年，获武汉市市政府人才专项津贴 2005 年，获武汉市科技新秀称号 2012 年，获武汉大学第七届 “尊师爱学”—— 我最喜爱的十佳优秀教师 2013 年，获武汉大学珞珈杰出学者 2013 年，获武汉大学十大师德标兵 2014 年，获武汉大学教学突出贡献校长奖 2014 年，获武汉大学医学部朱裕璧医学奖 2016 年，获湖北省政府特殊津贴 2016 年，获武汉大学珞珈杰出学者（续获） 2017 年，获武汉大学教学名师 2019 年，获湖北省第二届医学领军人才工程培养对象暨湖北名医工作室负责人

药物靶标与新药研发、外源物发育毒理；目前主要研究方向为外源物发育毒理及胎源性疾病早期防治

1) Geng H, Zhou MX, Li B, Liu L, Yang X, Wen YX, Yu HJ, Wang H*, Chen J*, Chen LB*. Metal-Drug Nanoparticles-Mediated Osteolytic Microenvironment Regulation for Enhanced Radiotherapy of Orthotopic Osteosarcoma. Chemical Engineering Journal. 2021; 417(8): 128103. (IF: 16.744) 2) Lu ZJ, Guo Y, Xu D, Xiao H, Kou H, Ao Y, Liu KX, Chen LB*, Wang H*. Developmental toxicity and programming alterations of multiple organs in offspring induced by medication during pregnancy. Acta Pharmaceutica Sinica B 2022 (IF: 14.903) 3) Li QX, Wen YX, Wang LL, Chen B, Chen J, Wang H*, Chen LB*. Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis. Exp Mol Med. 2021; 53(11): 1735. (IF: 12.153) 4) Ge CY, Xu D, Yu PX, Fang M, Guo JJ, Xu D, Qiao Y, Chen SJ, Zhang YZ*, Wang H*. P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss. BMC Med. 2021; 19(1): 311. (IF: 11.15) 5) Huang W, Zhou J, Guo JJ, Hu W, Chen GH, Li B, Wen YJ, Jiang YM, Fu KL, Bi HC*, Zhang YZ*, Wang H*. Dexamethasone induces an imbalanced fetal-placental-maternal bile acid circulation: Involvement of placental transporters. BMC Med. 2021; 19(1): 87. (IF: 11.15) 6) Dai Y, Kou H, Gui S, Guo X, Liu H, Gong Z, Sun X, Wang H*, Guo Y*. Prenatal dexamethasone exposure induced pancreatic β-cell dysfunction and glucose intolerance of male offspring rats: Role of the epigenetic repression of ACE2. Sci Total Environ. 2022; 826: 154095. (IF: 10.753) 7) Yu P, Zhou J, Ge C, Fang M, Zhang Y, Wang H*. Differential expression of placental 11β-HSD2 induced by high maternal glucocorticoid exposure mediates sex differences in placental and fetal development. Sci Total Environ. 2022; 827: 154396. (IF: 10.753) 8) Chen YW, Xia X, Fang M, Chen GH, Cao JG, Qu H, Wang H*. Maternally derived low glucocorticoid mediates adrenal developmental programming alteration in offspring induced by dexamethasone. Sci Total Environ. 2021; 797: 149084. (IF: 10.753) 9) He Z, Zhang JZ, Chen GH, Cao JG, Chen YW, Ai C, Wang H*. H19/let-7 axis mediates caffeine exposure during pregnancy induced adrenal dysfunction and its multi-generation inheritance. Sci Total Environ. 2021; 792: 148440. (IF: 10.753) 10) Lv F, Fan GL, Wan Y, Chen YX, Ni Y, Huang J, Xu D, Zhang W*, Wang H*. Intrauterine endogenous high glucocorticoids program ovarian dysfunction in female offspring secondary to prenatal caffeine exposure. Sci Total Environ. 2021; 789: 147691. (IF: 10.753) 11) Wu Z, Wen Y, Xiao H, Zhu J, Li B, Shangguan Y, He H, Wang H*, Chen L*. 11β-Hydroxysteroid dehydrogenase 2: A key mediator of high susceptibility to osteoporosis in offspring after prenatal dexamethasone exposure. Pharmacol Res. 2022; 175: 105990. (IF: 10.334) 12) Gong XH, Zhang JZ, Ge CY, Yi YW, Dai SY, Fan GL, Zhang YZ, Wang H*, Xu D*. miRNA320a-3p/RUNX2 signal programming mediates the transgenerational inheritance of inhibited ovarian estrogen synthesis in female offspring rats induced by prenatal dexamethasone exposure. Pharmacol Res. 2021; 165: 105435. (IF: 10.334) 13) Chen YW, Xu D, Xia X, Chen GH, Xiao H, Chen LB*, Wang H*. Sex difference in adrenal developmental toxicity induced by dexamethasone and its intrauterine programming mechanism. Pharmacol Res. 2021; 174: 105942. (IF: 10.334) 14) Li QX, Wang LL, Wang YZ, Liu L, Han H, Chen LB*, Wang H*. Programming changes in GLUT1 mediated the accumulation of AGEs andmatrix degradation in the articular cartilage of female adult rats after prenatal caffeine exposure. Pharmacol Res. 2020; 151: 104555. (IF: 10.334) 15) Xiao H, Wu ZX, Li B, Shangguan YF, Jean-François Stoltz, Jacques Magdalou, Chen LB *, Wang H*. The low-expression programming of 11β-HSD2 mediates osteoporosis susceptibility induced by prenatal caffeine exposure in male offspring rats. Br J Pharmacol. 2020; 177(20): 4683. (IF: 9.473)